1. Gene
  2. Traf3 - TNF receptor-associated factor 3 Gene

Traf3 - TNF receptor-associated factor 3 Gene

种属: Mus musculus

同用名: amn; LAP1; CAP-1; CRAF1; T-BAM; CD40bp; TRAFAMN

基因 ID: 22031 | 基因类型: protein coding

关于 Traf3

功能概要

Enables protein kinase binding activity. Involved in several processes, including regulation of defense response to virus; regulation of gene expression; and tumor necrosis factor-mediated signaling pathway. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; lower jaw epithelium; lung; and mandibular process. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human TRAF3 (TNF Receptor associated factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Traf3 基因产物(3)

mRNA Protein Name
NM_001286122.1 NP_001273051.1 TNF receptor-associated factor 3 isoform b
NM_001364364.1 NP_001351293.1 TNF receptor-associated factor 3 isoform b
NM_011632.3 NP_035762.2 TNF receptor-associated factor 3 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15102471 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
17158868 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
17015635 MGI
involved in regulation of cytokine production IMP
IMP: 通过突变表型推断
16306937 MGI
involved in regulation of defense response to virus IMP
IMP: 通过突变表型推断
16306937 MGI
involved in regulation of interferon-beta production IMP
IMP: 通过突变表型推断
16306937 MGI
involved in regulation of proteolysis IDA
IDA: 通过直接分析推断
17158868 MGI
involved in regulation of proteolysis IMP
IMP: 通过突变表型推断
17015635 MGI
involved in toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
16306937 MGI
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
17015635 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CD40 receptor complex IDA
IDA: 通过直接分析推断
20614026 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
20614026 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

TNF receptor-associated factor 3

CD40 receptor-associated factor 1

CD40-binding protein

RING-type E3 ubiquitin transferase TRAF3

Traf3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Traf3 Q60803 TBK1 Homo sapiens Q9UHD2
Anti Bait CoIP
16306936
种属间
Traf3 Q60803 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
27094905
种属内
Traf3 Q60803 Ticam1 Mus musculus Q80UF7
Anti Bait CoIP
16306937
种属内
Traf3 Q60803 Ticam1 Mus musculus Q80UF7
Anti Bait CoIP
16306936
种属内
Traf3 Q60803 Mavs Mus musculus Q8VCF0
Pull Down
16858409
种属内
Traf3 Q60803 Rps27a Mus musculus P62991
Anti Bait CoIP
23334419
种属内
Traf3 Q60803 Rps27a Mus musculus P62991
Anti Bait CoIP
18083102
种属内
Traf3 Q60803 Traf2 Mus musculus P39429
Anti Bait CoIP
20818435
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Traf3 NCBI NCBI:7187