2. Gene
  3. Pdk1 - pyruvate dehydrogenase kinase, isoenzyme 1 Gene

Pdk1 - pyruvate dehydrogenase kinase, isoenzyme 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丙酮酸脱氢酶激酶，同工酶 1

种属: Mus musculus

同用名: B830012B01; D530020C15Rik

基因 ID: 228026 | 基因类型: protein coding

关于 Pdk1

Chromosome 2: 71,703,568-71,734,202 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 208 orthologues, 4 paralogues and is associated with 3 phenotypes. Ubiquitous expression in heart adult (RPKM 12.2), thymus adult (RPKM 9.7) and 28 other tissues.

功能概要

预测该基因编码的蛋白可启动 ATP 绑定活动；相同的蛋白质结合活性；和蛋白激酶活性。参与调节丙酮酸的乙酰辅酶 A 生物合成过程。位于线粒体中。线粒体丙酮酸脱氢酶复合物的一部分。以多种结构表达，包括消化系统；脑;泌尿生殖系统；肢体间充质；和感觉器官。与人 PDK1（丙酮酸脱氢酶激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; identical protein binding activity; and protein kinase activity. Involved in regulation of acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Part of mitochondrial pyruvate dehydrogenase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb mesenchyme; and sensory organ. Orthologous to human PDK1 (pyruvate dehydrogenase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdk1 基因产物(2)

mRNA Protein Name
NM_001360002.1 NP_001346931.1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2
NM_172665.5 NP_766253.2 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
IMP: 通过突变表型推断
22195962 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of pyruvate dehydrogenase complex IDA
IDA: 通过直接分析推断
22195962 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pdk1 蛋白结构

BCDHK_Adom3

BCDHK_Adom3: pfam10436 (55 - 217)

HATPase_PDK-like

HATPase_PDK-like: cd16929 (221 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 434 a.a.
蛋白主名 其他名称

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial

PDH kinase 1

[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial

pyruvate dehydrogenase kinase, isozyme 1

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0645 Dicoumarol Inhibitor 99.89% 否
HY-124060 PS423 99.38% 否
Pre-clinical Phase
生物活性分子 (40)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10514 BX795 99.84% 否
HY-14981 GSK2334470 Inhibitor 99.78% 否
HY-121744 PS10 Inhibitor 99.01% 否
HY-N0047 Polyphyllin I 99.89% 否
HY-12492 VER-246608 Inhibitor 98.92% 否
HY-19564 JX06 99.78% 否
HY-11005 BX-912 99.13% 否
HY-15967 PS48 Activator 99.71% 否
HY-124379 TPCK 98.55% 否
HY-N6769 Radicicol Inhibitor 99.63% 否
HY-10547 OSU-03012 98.88% 否
HY-14440 MP7 Inhibitor 99.67% 否
HY-121629 PS210 Activator 98.30% 否
HY-13842 BX517 Inhibitor ≥98.0% 否
HY-15569 NU6102 Inhibitor 99.23% 否
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% 否
HY-114645 PDK1-IN-RS2 Inhibitor 98.50% 否
HY-13856 (R)-PS210 Inhibitor 98.09% 否
HY-149814 PDK-IN-1 Inhibitor 99.74% 否
HY-157299 PDK-IN-3 Inhibitor 99.87% 否
HY-10515 BX-320 Inhibitor 99.4% 否
HY-13851 PS47 98.83% 否
HY-129426 PDK1/Akt/Flt dual pathway inhibitor Inhibitor / 否
HY-117809 PDK1-IN-2 Inhibitor 98.90% 否
HY-151465 HIF-1α-IN-4 Inhibitor 99.95% 否
HY-151466 HIF-1α-IN-5 Inhibitor 99.95% 否
HY-156375 PKM2 activator 6 / 否
HY-W070306 PDK1-IN-1 Inhibitor 99.95% 否
HY-W998345 SMART1 Inhibitor 99.31% 否
HY-135773 CRTh2 antagonist 3 / 否
HY-13844 PDK1-IN-3 Inhibitor / 否
HY-149275 PKM2/PDK1-IN-1 / 否
HY-156109 PDK-IN-2 / 否
HY-P5450 PDKtide / 否
HY-RS10273 PDK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10274 Pdk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10275 Pdk1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117885 PF-5177624 Inhibitor / 否
HY-124288 PDK1/AurA-IN-1 / 否
HY-W837864 PDK1 allosteric modulator 1 Modulator 99.34% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pdk1 NCBI NCBI:5163
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z