1. Gene
  2. SIRT3 - sirtuin 3 Gene

SIRT3 - sirtuin 3 Gene

中文名称:沉默信息调节因子 2 相关酶类 3

种属: Homo sapiens

同用名: SIR2L3

基因 ID: 23410 | 基因类型: protein coding

关于 SIRT3

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:215,030-236,931 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 6.7), brain (RPKM 5.6) and 25 other tissues.

功能概要

SIRT3 编码 III 类组蛋白脱乙酰酶的 沉默信息调节因子 2 相关酶类 家族成员,与酵母 Sir2 蛋白同源。编码的蛋白质只存在于线粒体中,它可以消除活性氧,抑制细胞凋亡,并防止癌细胞的形成。 SIRT3 对核基因表达、癌症、心血管疾病、神经保护、衰老和代谢控制具有深远影响。[RefSeq 提供,2019 年 5 月]

SIRT3 encodes a member of the Sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate Reactive Oxygen Species, inhibit Apoptosis, and prevent the formation of Cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, Cancer, Cardiovascular Disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

SIRT3 基因产物(38)

mRNA Protein Name
NR_163402.1
NM_001370316.1 NP_001357245.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform g precursor
NR_163388.1
NR_163400.1
NR_163395.1
NM_001370317.1 NP_001357246.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform h
NR_163386.1
XM_011519957.3 XP_011518259.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NR_163387.1
NR_163392.1
NR_163396.1
NR_163391.1
NM_001370310.1 NP_001357239.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform c
NR_163390.1
NR_163394.1
NM_001017524.3 NP_001017524.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NR_163398.1
NM_001370325.1 NP_001357254.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j
XR_007062467.1
NM_001370312.1 NP_001357241.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform d
NM_001370319.1 NP_001357248.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
XM_017017431.2 XP_016872920.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NM_001370320.1 NP_001357249.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NR_163401.1
NR_163393.1
NR_163399.1
NM_001370318.1 NP_001357247.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform b
NM_001370324.1 NP_001357253.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform j
XM_011519956.3 XP_011518258.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1
NM_001370323.1 NP_001357252.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NR_163397.1
NM_012239.6 NP_036371.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform a
NM_001370322.1 NP_001357251.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NM_001370321.1 NP_001357250.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform i
NR_163389.1
NM_001370314.1 NP_001357243.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform e
NM_001370315.1 NP_001357244.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform f precursor
XM_047426677.1 XP_047282633.1 NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16788062 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
29445193 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
19535340 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aerobic respiration IMP
IMP: 通过突变表型推断
22309213 GOA
involved in peptidyl-lysine deacetylation IMP
IMP: 通过突变表型推断
22309213 GOA
involved in positive regulation of catalase activity IDA
IDA: 通过直接分析推断
25210848 GOA
involved in positive regulation of superoxide dismutase activity IDA
IDA: 通过直接分析推断
25210848 GOA
involved in protein deacetylation IDA
IDA: 通过直接分析推断
16788062 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
12186850 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
16079181 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23283301 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SIRT3 蛋白结构

SIR2

SIR2: Sir2 family (145 - 326)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

NAD-dependent deacetylase sirtuin-3, mitochondrial

SIR2-like protein 3

mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase

regulatory protein SIR2 homolog 3

silent mating type information regulation 2, S.cerevisiae, homolog 3

sir2-like 3

sirtuin type 3

关联疾病

疾病名称 别名
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Diabetes Mellitus

Diabetes

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Aging
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Non-Alcoholic Fatty Liver Disease

Fatty Liver

Non-Alcoholic Fatty Liver

Nafld

Nonalcoholic Fatty Liver Disease

Nonalcoholic Steatohepatitis

Steatosis

Nafl

Nash

Non-Alcoholic Steatohepatitis

Susceptibility To Nonalcoholic Fatty Liver Disease

Steatohepatitis

Fatty Degeneration

Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis

Nafld Without Nash

Nafld Without Mention Of Nash

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SIRT3 VGNC VGNC:46184
Felis catus SIRT3 VGNC VGNC:65157
Rattus norvegicus SIRT3 RGD RGD:1308374
Bos taurus SIRT3 VGNC VGNC:34632
Macaca mulatta SIRT3 VGNC VGNC:77234
Mus musculus SIRT3 MGD MGI:1927665
Others SIRT3 NCBI