2. Gene
  3. LY96 - lymphocyte antigen 96 Gene

LY96 - lymphocyte antigen 96 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：淋巴细胞抗原 96

种属: Homo sapiens

同用名: MD2; MD-2; ly-96; ESOP-1

基因 ID: 23643 | 基因类型: protein coding

关于 LY96

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:73,991,392-74,099,857 (from NCBI)

This gene has 2 transcripts (splice variants) and 111 orthologues. Broad expression in spleen (RPKM 8.6), appendix (RPKM 8.4) and 22 other tissues.

功能概要

该基因编码的蛋白质与细胞表面的 toll 样受体 4 相关，并赋予对脂多糖 (LPS) 的反应性，从而提供受体与 LPS 信号之间的联系。对小鼠直系同源物的研究表明该基因可能参与内毒素中和。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 9 月]

This gene encodes a protein which associates with Toll-like Receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

LY96 基因产物(2)

mRNA Protein Name
NM_001195797.2 NP_001182726.1 lymphocyte antigen 96 isoform 2 precursor
NM_015364.5 NP_056179.4 lymphocyte antigen 96 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lipopolysaccharide immune receptor activity IDA
IDA: 通过直接分析推断
19252480 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15728506 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in detection of lipopolysaccharide IDA
IDA: 通过直接分析推断
19252480 GOA
acts upstream of or within response to lipopolysaccharide IDA
IDA: 通过直接分析推断
12594207 GOA
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
14607928 GOA
involved in toll-like receptor signaling pathway IDA
IDA: 通过直接分析推断
14607928 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of lipopolysaccharide receptor complex IDA
IDA: 通过直接分析推断
11274165 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11274165 GOA
part of receptor complex IPI
IPI: 通过物理相互作用推断
19252480 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LY96 蛋白结构

E1_DerP2_DerF2

E1_DerP2_DerF2: ML domain (31 - 152)

  • 0
  • 100
  • 160 a.a.
蛋白主名 其他名称

lymphocyte antigen 96

myeloid differentiation protein-2

LY96 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LY96 Q9Y6Y9 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
种属内
LY96 Q9Y6Y9 LCN2 Homo sapiens P80188
Y2H Array
32296183
种属内
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206-1
GMS
19252480
种属内
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206-1
Solid Phase Assay
22474354
种属内
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206-1
X-Ray Diffraction
19252480
种属内
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206
Anti Tag CoIP
15728506
种属内
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206
Crosslink
17803912
种属内
LY96 Q9Y6Y9 TLR4 Homo sapiens O00206
GMS
17803912
种属内
LY96 Q9Y6Y9 MESD Homo sapiens Q14696
Y2H Prey Pooling
32296183
种属内
LY96 Q9Y6Y9 MESD Homo sapiens Q14696
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LY96 蛋白

目录号 产品名 蛋白编号 纯度
HY-P701067 MD2 Protein, Human (His) Q9Y6Y9-1 (Q19-N160) ≥95%

关联疾病

疾病名称 别名
Melioidosis

Melioidosis, Susceptibility To

Acute And Fulminating Melioidosis

Nightcliff Gardener'S Disease

Pseudoglanders

Subacute And Chronic Melioidosis

Burkholderia Pseudomallei Infection

Whitmore Disease

Whitmore'S Disease

B Pseudomallei Infection

Epizootic Lymphangitis

Infection Due To Burkholderia Pseudomallei

Infection Due To Burkholderia Pseudomallei Nos

Infection Due To Malleomyces Pseudomallei

Infection Due To Pseudomonas Pseudomallei

Infection Due To Pseudomonas Pseudomallei Nos

Infection Due To Whitmore Bacillus

Stanton Disease
Toxic Shock Syndrome

Septic Shock

Toxic Shock

Tss

Shock, Septic

Staphylococcal Toxic Shock Syndrome

Tss - [Toxic Shock Syndrome]
Thyrotoxic Exophthalmos
Endocrine Exophthalmos

Endocrine Exopthalmos

Thyroid Associated Opthalmopathies
Inflammatory Bowel Disease 20

IBD20
Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix
Bacterial Sepsis
Niemann-Pick Disease, Type C2

NPC2

Niemann-Pick Disease Type C2

Niemann-Pick C2 Disease

Niemann-Pick Disease C2
Wheat Allergy

Wheat Allergic Reaction

Wheat Hypersensitivity

Allergy To Wheat

Allergy Wheat
Acute Cervicitis
Disease By Infectious Agent

Infectious Disease

Infectious Diseases
Cataract 30

Cataract 30 Pulverulent

Cataract Coppock-Like

Ctrct30

Dusty Cataract

Cataract, Type 30
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07908 LY96 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LY96 MGD MGI:1341909
Rattus norvegicus LY96 RGD RGD:1302993
Bos taurus LY96 VGNC VGNC:53867
Canis familiaris LY96 VGNC VGNC:42878
Felis catus LY96 VGNC VGNC:63335
Macaca mulatta LY96 VGNC VGNC:74303
Macaca fascicularis LY96 NCBI NCBI:102118398
Others LY96 NCBI
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