2. Gene
  3. Scd - stearoyl-CoA desaturase Gene

Scd - stearoyl-CoA desaturase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：硬脂酰辅酶 A 去饱和酶

种属: Rattus norvegicus

同用名: Scd1

基因 ID: 246074 | 基因类型: protein coding

关于 Scd

Primary_assembly 1: 243,269,747-243,282,562 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 29 orthologues, 3 paralogues and is associated with 16 phenotypes. Biased expression in Liver (RPKM 4781.4), Adrenal (RPKM 4523.2) and 5 other tissues.

功能概要

该基因编码的蛋白可启动铁离子结合活性和硬脂酰辅酶 A 9-去饱和酶活性。参与响应脂肪酸和不饱和脂肪酸的生物合成过程。位于细胞内膜界的细胞器中。是膜的组成部分。用于研究癌症。高胰岛素血症的生物标志物。与人 SCD（硬脂酰辅酶 A 去饱和酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in response to fatty acid and unsaturated fatty acid biosynthetic process. Located in intracellular membrane-bounded organelle. Is integral component of membrane. Used to study carcinoma. Biomarker of hyperinsulinism. Orthologous to human SCD (stearoyl-CoA desaturase). [provided by Alliance of Genome Resources, Apr 2022]

Scd 基因产物(1)

mRNA Protein Name
NM_139192.2 NP_631931.2 acyl-CoA desaturase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables iron ion binding IDA
IDA: 通过直接分析推断
2892838 RGD
enables oxidoreductase activity IMP
IMP: 通过突变表型推断
7947684 RGD
enables stearoyl-CoA 9-desaturase activity IDA
IDA: 通过直接分析推断
2892838 RGD
enables stearoyl-CoA 9-desaturase activity IMP
IMP: 通过突变表型推断
7947684 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lipid biosynthetic process IEP
IEP: 通过表达模式推断
12896875 RGD
involved in response to fatty acid IDA
IDA: 通过直接分析推断
1982442 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
26394137 RGD
involved in unsaturated fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
2892838 RGD
involved in unsaturated fatty acid biosynthetic process IMP
IMP: 通过突变表型推断
7947684 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
2892838 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Scd 蛋白结构

Delta9-FADS-like

Delta9-FADS-like: cd03505 (98 - 335)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
蛋白主名 其他名称

acyl-CoA desaturase 1

delta(9)-desaturase 1

fatty acid desaturase 1

stearoyl-CoA desaturase 1

stearoyl-Coenzyme A desaturase 1

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-18681 Voxelotor Inhibitor 99.97% 是
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-19796 Icomidocholic acid ≥99.0% Phase 3
HY-13070 MK-8245 Inhibitor 99.04% Phase 2
HY-13077 MK-8245 Trifluoroacetate Inhibitor 98.09% Phase 2
Pre-clinical Phase
生物活性分子 (44)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-50709 A939572 Inhibitor 99.98% 否
HY-15823 CAY10566 Inhibitor 99.82% 否
HY-15822 MF-438 Inhibitor 99.92% 否
HY-15700 PluriSIn 1 99.84% 否
HY-12756A E6446 dihydrochloride 99.96% 否
HY-124751 YTX-465 Inhibitor 99.06% 否
HY-19762 GSK1940029 Inhibitor 99.82% 否
HY-124876 SynuClean-D 99.89% 否
HY-148788 Osivelotor 99.83% 否
HY-N6807 Elemicin Inhibitor 99.22% 否
HY-124346 T-3364366 Inhibitor 99.73% 否
HY-100249 XEN723 Inhibitor 99.90% 否
HY-127143 Sterculic acid Inhibitor ≥99.0% 否
HY-141525 SCD1 inhibitor-4 Inhibitor 98.93% 否
HY-155033 SSI-4 Inhibitor 99.95% 否
HY-12756 E6446 ≥98.0% 否
HY-P3180 Hemoglobin S ≥99.0% 否
HY-11034 CVT-12012 Inhibitor 99.16% 否
HY-113638 CVT-11127 99.88% 否
HY-133180 YW1128 Inhibitor 99.38% 否
HY-112812 SCD1 inhibitor-1 Inhibitor 99.78% 否
HY-139077 SCD1 inhibitor-3 Inhibitor 98.55% 否
HY-159098 dWIZ-1 Degrader / 否
HY-102045 T-3764518 Inhibitor 99.86% 否
HY-155403 SCD1/5-IN-1 Inhibitor 99.58% 否
HY-E70265 18:0 Coenzyme A triammonium ≥99.0% 否
HY-132847 Vibozilimod Agonist 99.52% 否
HY-139293 PF-07059013 / 否
HY-111315 XEN103 Inhibitor / 否
HY-114184 MK-8245 analog Inhibitor / 否
HY-118117 Rovatirelin / 否
HY-150125 SCD1-IN-1 Inhibitor / 否
HY-152775A RK-0133114 Inhibitor / 否
HY-159099 HbF inducer 2 Degrader / 否
HY-161787 G9a-IN-2 Inhibitor / 否
HY-E70023 Sphingolipid ceramide N-deacylase (SCDase) / 否
HY-RS12494 SCD Human Pre-designed siRNA Set A / 否
HY-RS12495 Scd Rat Pre-designed siRNA Set A / 否
HY-RS12496 Scd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12497 SCD5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-155209 SCD1 inhibitor-5 Inhibitor / 否
HY-163820 WIZ degrader 4 Degrader / 否
HY-163824 WIZ degrader 7 Degrader / 否
HY-W013627S trans,trans-2,4-Decadienal-d4 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scd NCBI NCBI:6319
Canis familiaris Scd NCBI NCBI:486839
Macaca fascicularis Scd NCBI NCBI:102120948
Mus musculus Scd NCBI
Leporidae Scd NCBI
Macaca mulatta Scd NCBI NCBI:710155
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