2. Gene
  3. Stat5b - signal transducer and activator of transcription 5B Gene

Stat5b - signal transducer and activator of transcription 5B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：信号转导和转录激活因子 5 B

种属: Rattus norvegicus

基因 ID: 25126 | 基因类型: protein coding

关于 Stat5b

Primary_assembly 10: 85,705,670-85,775,668 reverse strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 286 orthologues, 5 paralogues and is associated with 17 phenotypes. Biased expression in Muscle (RPKM 432.5), Thymus (RPKM 364.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 DNA 结合活性； DNA结合转录因子活性；和染色质结合活性。参与多个过程，包括细胞对表皮生长因子刺激的反应；黄体化；和受体信号通路通过 JAK-STAT。位于细胞质和细胞核中。该基因的人类直向同源基因与免疫失调的生长激素不敏感综合征 1 和免疫失调的生长激素不敏感综合征 2 相关。与人类 STAT5B（信号转导和转录激活因子 5B）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; luteinization; and receptor signaling pathway via JAK-STAT. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1 and growth hormone insensitivity syndrome with immune dysregulation 2. Orthologous to human STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Apr 2022]

Stat5b 基因产物(1)

mRNA Protein Name
NM_022380.2 NP_071775.1 signal transducer and activator of transcription 5B
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11562369 RGD
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
11064147 RGD
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
16527988 RGD
enables chromatin binding IDA
IDA: 通过直接分析推断
20639532 RGD
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
11064147 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10720695 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11064147 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acute-phase response IDA
IDA: 通过直接分析推断
17565389 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
11064147 RGD
involved in cellular response to epidermal growth factor stimulus IDA
IDA: 通过直接分析推断
20639532 RGD
involved in liver development IDA
IDA: 通过直接分析推断
17565389 RGD
involved in luteinization IDA
IDA: 通过直接分析推断
10598581 RGD
involved in positive regulation of fibroblast growth factor production IMP
IMP: 通过突变表型推断
16527988 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
16527988 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
16527988 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
16527988 RGD
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11562369 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
12933671 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
16730240 RGD
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
17327369 RGD
involved in response to peptide hormone IDA
IDA: 通过直接分析推断
9092792 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
10224108 RGD
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11064147 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Stat5b 蛋白结构

STAT_int

STAT_int: pfam02865 (64 - 132)

STAT5_CCD

STAT5_CCD: cd16855 (147 - 338)

STAT5_DBD

STAT5_DBD: cd16849 (340 - 497)

SH2_STAT5b

SH2_STAT5b: cd10420 (581 - 725)

  • 0
  • 200
  • 400
  • 600
  • 795 a.a.
蛋白主名 其他名称

signal transducer and activator of transcription 5B

Signal transducer and activator of transcription 5a

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148813 AK-2292 99.73% 否
HY-136546 Stafia-1 Inhibitor 99.37% 否
HY-112647 Stafib-1 Inhibitor ≥98.0% 否
HY-19527 IST5-002 99.36% 否
HY-112648 Stafib-2 Inhibitor 98.42% 否
HY-112649 Pomstafib-2 99.37% 否
HY-RS13893 STAT5B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13894 Stat5b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13895 Stat5b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Stat5b NCBI NCBI:6777
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