2. Gene
  3. Dyrk1a - dual specificity tyrosine phosphorylation regulated kinase 1A Gene

Dyrk1a - dual specificity tyrosine phosphorylation regulated kinase 1A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：双特异性酪氨酸磷酸化调节激酶1A

种属: Rattus norvegicus

同用名: Dyrk; PSK47

基因 ID: 25255 | 基因类型: protein coding

关于 Dyrk1a

Primary_assembly 11: 33,890,490-34,009,420 forward strand.mRatBN7.2:CM026984.1

This gene has 4 transcripts (splice variants), 236 orthologues, 11 paralogues and is associated with 20 phenotypes. Biased expression in Thymus (RPKM 179.), Muscle (RPKM 155.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动蛋白丝氨酸/苏氨酸激酶活性和蛋白酪氨酸激酶活性。参与蛋白质磷酸化和 RNA 剪接的调节。位于核斑点。该基因的人类直系同源物与唐氏综合症有关；自闭症谱系障碍；常染色体显性非综合征性智力障碍 7；和智力障碍。与人类 DYRK1A（双重特异性酪氨酸磷酸化调节激酶 1A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation and regulation of RNA splicing. Located in nuclear speck. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk1a 基因产物(1)

mRNA Protein Name
NM_012791.3 NP_036923.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28755400 RGD
enables protein kinase activity IDA
IDA: 通过直接分析推断
11877424 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
8631952 RGD
enables protein serine/threonine kinase activity IGI
IGI: 通过遗传相互作用推断
25556849 RGD
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
8631952 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
21273244 RGD
involved in cardiac muscle hypertrophy IEP
IEP: 通过表达模式推断
19906449 RGD
involved in negative regulation of cell cycle IMP
IMP: 通过突变表型推断
27056896 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
21215488 RGD
involved in peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
25556849 RGD
involved in peptidyl-threonine phosphorylation IGI
IGI: 通过遗传相互作用推断
25556849 RGD
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
8631952 RGD
involved in positive regulation of RNA splicing IMP
IMP: 通过突变表型推断
28377597 RGD
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
8631952 RGD
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
21273244 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
8631952 RGD
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
22767602 RGD
involved in regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
27056896 RGD
involved in regulation of cell growth involved in cardiac muscle cell development IMP
IMP: 通过突变表型推断
21273244 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear speck IDA
IDA: 通过直接分析推断
9748265 RGD
NOT located in nucleolus IDA
IDA: 通过直接分析推断
9748265 RGD
located in nucleus IDA
IDA: 通过直接分析推断
9748265 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Dyrk1a 蛋白结构

PKc_DYRK1

PKc_DYRK1: cd14226 (147 - 483)

  • 0
  • 200
  • 400
  • 600
  • 763 a.a.
蛋白主名 其他名称

dual specificity tyrosine-phosphorylation-regulated kinase 1A

Dual Specificity Yak1-related kinase

MNBH

RP86

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

protein kinase minibrain homolog

相关产品

Pre-clinical Phase
生物活性分子 (63)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115470 CLK-IN-T3 Inhibitor 98.63% 否
HY-105309 GSK-626616 Inhibitor 99.77% 否
HY-112296 T025 98.84% 否
HY-132308 DYRK1-IN-1 Inhibitor 99.71% 否
HY-111380 EHT 1610 Inhibitor 98.16% 否
HY-101298 Paprotrain Inhibitor 99.87% 否
HY-142295 GNF2133 Inhibitor 98.49% 否
HY-15951 ML167 Inhibitor 98.62% 否
HY-108476 INDY Inhibitor 99.51% 否
HY-12838 RO5454948 Inhibitor 99.53% 否
HY-146221 Dyrk1A-IN-5 Inhibitor 98.56% 否
HY-15569 NU6102 Inhibitor 99.23% 否
HY-101029 MBM-55 99.94% 否
HY-111379 EHT 5372 Inhibitor 98.12% 否
HY-135906 CK2/ERK8-IN-1 ≥99.0% 否
HY-129492 GNF4877 Inhibitor 99.41% 否
HY-117049 Leucettine L41 Inhibitor 98.70% 否
HY-147066 Dyrk1A-IN-4 Inhibitor 99.90% 否
HY-144290 ARN25068 Inhibitor 99.66% 否
HY-12828A KH-CB20 Inhibitor 99.80% 否
HY-147060 Dyrk1A-IN-3 Inhibitor 99.96% 否
HY-149262 CLK1-IN-3 98.03% 否
HY-156816 ON 108600 Inhibitor 99.73% 否
HY-110052 TBCA Inhibitor 99.45% 否
HY-128758A DYRKs-IN-1 hydrochloride Inhibitor 99.71% 否
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% 否
HY-RS04095 Dyrk1a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-128758 DYRKs-IN-1 Inhibitor / 否
HY-101029A MBM-55S / 否
HY-128759 DYRKs-IN-2 Inhibitor / 否
HY-129449 AnnH31 Inhibitor 99.91% 否
HY-139830 Dyrk1A-IN-1 Inhibitor / 否
HY-142295A GNF2133 hydrochloride Inhibitor / 否
HY-144614 JH-XVII-10 / 否
HY-144617 JH-XIV-68-3 Inhibitor / 否
HY-144695 Dyrk1A/α-synuclein-IN-1 Inhibitor / 否
HY-144696 Dyrk1A/α-synuclein-IN-2 Inhibitor / 否
HY-144826 ZDWX-25 Inhibitor / 否
HY-146337 Dyrk1A/B-IN-1 Inhibitor / 否
HY-146586 Haspin-IN-1 Inhibitor / 否
HY-146587 Haspin-IN-2 Inhibitor / 否
HY-147760 Dyrk1A-IN-2 Inhibitor / 否
HY-150537 AChE/GSK-3β-IN-1 Inhibitor / 否
HY-152183 FINDY Inhibitor / 否
HY-155723 Leucettinib-92 Inhibitor / 否
HY-157995 Dyrk1A-IN-7 Inhibitor / 否
HY-158212 Dyrk1A-IN-8 Inhibitor / 否
HY-159496 Dyrk1A-IN-10 Inhibitor / 否
HY-162750 ZJCK-6-46 Inhibitor / 否
HY-163514 hAChE-IN-8 Inhibitor / 否
HY-168195 DYR530 / 否
HY-168265 Dyrk1A-IN-11 Inhibitor / 否
HY-77324S 4-(Trifluoromethyl)aniline-d4 Inhibitor 99.23% 否
HY-N2892 Aristolactam A IIIa Inhibitor / 否
HY-RS04094 DYRK1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04096 Dyrk1a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-108475 ProINDY Inhibitor / 否
HY-122989 Aristolactam BIII Inhibitor / 否
HY-162107 Dyrk1A-IN-6 Inhibitor / 否
HY-162597 Dyrk1A-IN-9 Inhibitor / 否
HY-168194 DYR684 Degrader / 否
HY-168196 DYR684m / 否
HY-34222 7-Deazaguanine Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dyrk1a NCBI NCBI:1859
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