2. Gene
  3. Drd4 - dopamine receptor D4 Gene

Drd4 - dopamine receptor D4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：多巴胺受体 D4

种属: Rattus norvegicus

同用名: D4RA

基因 ID: 25432 | 基因类型: protein coding

关于 Drd4

Primary_assembly 1: 196,396,366-196,399,553 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 247 orthologues, 35 paralogues and is associated with 28 phenotypes. Biased expression in Heart (RPKM 5.8), Thymus (RPKM .8) and 3 other tissues.

功能概要

该基因编码的蛋白可启动多巴胺结合活动；多巴胺神经递质受体活性，通过 Gi/Go 耦合；和杂环化合物结合活性。涉及多个过程，包括行为恐惧反应；学习或记忆；和化学突触传递的调节。位于多个细胞成分中，包括树突棘；神经细胞体；和终端按钮。在 GABA 能突触和谷氨酸能突触中活跃。是突触后膜的组成部分和突触前膜的组成部分。注意缺陷多动障碍和肥胖的生物标志物。该基因的人类直系同源物与多种疾病有关，包括吉尔斯德拉图雷特综合征；反社会人格障碍；注意力缺陷多动障碍;品行障碍;和阅读障碍。与人类 DRD4（多巴胺受体 D4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including behavioral fear response; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; neuronal cell body; and terminal bouton. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Orthologous to human DRD4 (Dopamine Receptor D4). [provided by Alliance of Genome Resources, Apr 2022]

Drd4 基因产物(1)

mRNA Protein Name
NM_012944.2 NP_037076.2 D(4) dopamine receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables dopamine binding IDA
IDA: 通过直接分析推断
15448188 RGD
enables dopamine binding IPI
IPI: 通过物理相互作用推断
8078498 RGD
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
IDA: 通过直接分析推断
12711714 RGD
enables heterocyclic compound binding IDA
IDA: 通过直接分析推断
8078498 RGD
enables heterocyclic compound binding IPI
IPI: 通过物理相互作用推断
8078498 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
14499480 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled dopamine receptor signaling pathway IDA
IDA: 通过直接分析推断
12711714 RGD
involved in associative learning IMP
IMP: 通过突变表型推断
15987936 RGD
involved in behavioral fear response IMP
IMP: 通过突变表型推断
16708027 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
18778704 RGD
involved in modulation of inhibitory postsynaptic potential IDA
IDA: 通过直接分析推断
12417643 RGD
involved in negative regulation of synaptic transmission IDA
IDA: 通过直接分析推断
17314300 RGD
involved in negative regulation of synaptic transmission, GABAergic IDA
IDA: 通过直接分析推断
12417643 RGD
involved in negative regulation of vascular associated smooth muscle cell migration IDA
IDA: 通过直接分析推断
24888351 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
24888351 RGD
involved in olfactory learning IMP
IMP: 通过突变表型推断
15987936 RGD
involved in photoperiodism IEP
IEP: 通过表达模式推断
18321474 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
21622557 RGD
involved in positive regulation of penile erection IDA
IDA: 通过直接分析推断
15814200 RGD
involved in prepulse inhibition IMP
IMP: 通过突变表型推断
9497025 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
24155292 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
24155292 RGD
involved in regulation of calcium-mediated signaling IMP
IMP: 通过突变表型推断
15229297 RGD
involved in regulation of neurotransmitter secretion IMP
IMP: 通过突变表型推断
15363981 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels EXP
EXP: 通过实验结果推断
14586014 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
14586014 RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
IEP: 通过表达模式推断
14586014 RGD
involved in regulation of protein kinase A signaling IDA
IDA: 通过直接分析推断
12417643 RGD
involved in response to epinephrine IEP
IEP: 通过表达模式推断
19482058 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
23413777 RGD
involved in response to light stimulus IEP
IEP: 通过表达模式推断
19482058 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
18809391 RGD
involved in response to thyroid hormone IEP
IEP: 通过表达模式推断
19482058 RGD
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
18778704 RGD
involved in short-term memory IMP
IMP: 通过突变表型推断
15138447 RGD
involved in synaptic transmission, dopaminergic IMP
IMP: 通过突变表型推断
15476261 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
24155292 RGD
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
24155292 RGD
located in Golgi apparatus IDA
IDA: 通过直接分析推断
11902112 RGD
located in axon IDA
IDA: 通过直接分析推断
10819901 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
14519509 RGD
located in cell cortex IDA
IDA: 通过直接分析推断
10898094 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
11902112 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
11902112 RGD
located in dendrite IDA
IDA: 通过直接分析推断
10819901 RGD
located in dendrite terminus IDA
IDA: 通过直接分析推断
11902112 RGD
located in dendritic microtubule IDA
IDA: 通过直接分析推断
11902112 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
11902112 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
10819901 RGD
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
11902112 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
14586014 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
14586014 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
11902112 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
10898094 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
11902112 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
12133912 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
14519509 RGD
located in presynapse IDA
IDA: 通过直接分析推断
11902112 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
14519509 RGD
located in synapse IDA
IDA: 通过直接分析推断
11902112 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
10819901 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Drd4 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (43 - 380)

7tm_GPCRs

7tm_GPCRs: cd14964 (68 - 90)

7tm_GPCRs

7tm_GPCRs: cd14964 (107 - 129)

7tm_GPCRs

7tm_GPCRs: cd14964 (150 - 166)

7tm_GPCRs

7tm_GPCRs: cd14964 (186 - 209)

7tm_GPCRs

7tm_GPCRs: cd14964 (314 - 336)

7tm_GPCRs

7tm_GPCRs: cd14964 (348 - 373)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
蛋白主名 其他名称

D(4) dopamine receptor

d(2C) dopamine receptor

dopamine D4 receptor

dopamine receptor 4

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125751 UCSF924 Agonist 99.56% 否
HY-147398 Dopamine D4 receptor antagonist-1 Antagonist 99.17% 否
HY-101349 L 741742 / 否
HY-103407 PD 168568 Antagonist / 否
HY-103407A PD 168568 dihydrochloride Antagonist / 否
HY-RS04003 DRD4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04004 Drd4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04005 Drd4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-17390BS Loxapine-d8 hydrochloride Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Drd4 NCBI NCBI:1815
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