2. Gene
  3. Lep - leptin Gene

Lep - leptin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: OB; obese

基因 ID: 25608 | 基因类型: protein coding

关于 Lep

功能概要

Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; fatty liver disease (multiple); lipid metabolism disorder (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital Leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (Leptin). [provided by Alliance of Genome Resources, Apr 2022]

Lep 基因产物(1)

mRNA Protein Name
NM_013076.3 NP_037208.1 leptin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone activity IDA
IDA: 通过直接分析推断
9070213 RGD
enables peptide hormone receptor binding IDA
IDA: 通过直接分析推断
9070213 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17324488 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
15131016 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone mineralization involved in bone maturation IDA
IDA: 通过直接分析推断
21353474 RGD
involved in cardiac muscle hypertrophy IDA
IDA: 通过直接分析推断
20738325 RGD
involved in cellular response to L-ascorbic acid IEP
IEP: 通过表达模式推断
20400526 RGD
involved in cellular response to retinoic acid IEP
IEP: 通过表达模式推断
19212007 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
21164040 RGD
involved in energy reserve metabolic process IDA
IDA: 通过直接分析推断
12058043 RGD
involved in fatty acid catabolic process IDA
IDA: 通过直接分析推断
12058043 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
21303957 RGD
involved in glycerol biosynthetic process IDA
IDA: 通过直接分析推断
21068181 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
12130569 RGD
involved in leptin-mediated signaling pathway IDA
IDA: 通过直接分析推断
9070213 RGD
involved in leukocyte tethering or rolling IDA
IDA: 通过直接分析推断
20150963 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
19730157 RGD
involved in negative regulation of appetite by leptin-mediated signaling pathway IDA
IDA: 通过直接分析推断
11677594 RGD
involved in negative regulation of cartilage development IDA
IDA: 通过直接分析推断
19876764 RGD
involved in negative regulation of glutamine transport IMP
IMP: 通过突变表型推断
20448142 RGD
involved in negative regulation of lipid storage IDA
IDA: 通过直接分析推断
17024416 RGD
involved in negative regulation of metabolic process IDA
IDA: 通过直接分析推断
12130569 RGD
involved in negative regulation of vasoconstriction IDA
IDA: 通过直接分析推断
20978518 RGD
involved in ovulation from ovarian follicle IDA
IDA: 通过直接分析推断
17071778 RGD
involved in phagocytosis IDA
IDA: 通过直接分析推断
9438411 RGD
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
9618284 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
18978578 RGD
involved in positive regulation of cytokine production IEP
IEP: 通过表达模式推断
19922787 RGD
involved in positive regulation of fat cell apoptotic process IDA
IDA: 通过直接分析推断
17024416 RGD
involved in positive regulation of follicle-stimulating hormone secretion IEP
IEP: 通过表达模式推断
19112389 RGD
involved in positive regulation of hepatic stellate cell activation IDA
IDA: 通过直接分析推断
19299451 RGD
involved in positive regulation of insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
20977462 RGD
involved in positive regulation of luteinizing hormone secretion IEP
IEP: 通过表达模式推断
19112389 RGD
involved in positive regulation of monoatomic ion transport IDA
IDA: 通过直接分析推断
20203064 RGD
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
IDA: 通过直接分析推断
20738325 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
11677594 RGD
involved in positive regulation of protein modification process IMP
IMP: 通过突变表型推断
19726711 RGD
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
20738325 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
21250909 RGD
involved in regulation of blood pressure IDA
IDA: 通过直接分析推断
20059648 RGD
involved in regulation of lipoprotein lipid oxidation IDA
IDA: 通过直接分析推断
21068181 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
23178146 RGD
involved in response to dietary excess IMP
IMP: 通过突变表型推断
19726711 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
12412816 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
23380443 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
15284063 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
15616803 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
21060836 RGD
involved in response to vitamin E IEP
IEP: 通过表达模式推断
20404018 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
17324488 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
9590691 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

leptin

obesity factor

重组 Lep 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7233 Leptin Protein, Rat P50596 (V22-C167) ≥95%
HY-P7233A Leptin Protein, Rat (His) P50596 (V22-C167) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07593 LEP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lep NCBI NCBI:3952
Mus musculus Lep NCBI NCBI:16846
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