GALNT2 - polypeptide N-acetylgalactosaminyltransferase 2 Gene

中文名称：多肽 N-乙酰半乳糖氨基转移酶 2

种属: Homo sapiens

同用名: CDG2T; GalNAc-T2

基因 ID: 2590 | 基因类型: protein coding

关于 GALNT2

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:230,057,789-230,282,122 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues, 19 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 16.5), appendix (RPKM 14.3) and 25 other tissues.

功能概要

该基因编码糖基转移酶 2 蛋白家族的一个成员。该家族的成员在高尔基体中启动肽的粘蛋白型 O-糖基化。编码的蛋白质可能参与免疫球蛋白 A1 铰链区的 O-连接糖基化。该基因可能会影响甘油三酯水平，并可能与 2 型糖尿病以及多种癌症有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 5 月]

This gene encodes a member of the Glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of Peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GALNT2 基因产物(2)

mRNA	Protein	Name
NM_001291866.2	NP_001278795.1	polypeptide N-acetylgalactosaminyltransferase 2 isoform 2
NM_004481.5	NP_004472.1	polypeptide N-acetylgalactosaminyltransferase 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables manganese ion binding	IDA IDA: 通过直接分析推断	9295285	GOA
enables polypeptide N-acetylgalactosaminyltransferase activity	IDA IDA: 通过直接分析推断	9295285	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21699783	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in O-glycan processing	IDA IDA: 通过直接分析推断	18562306	GOA
involved in protein O-linked glycosylation	IDA IDA: 通过直接分析推断	16434399	GOA
involved in protein O-linked glycosylation via serine	IDA IDA: 通过直接分析推断	9295285	GOA
involved in protein O-linked glycosylation via threonine	IDA IDA: 通过直接分析推断	9295285	GOA
involved in protein maturation	IDA IDA: 通过直接分析推断	12438318	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with Golgi apparatus	IDA IDA: 通过直接分析推断	12506059	GOA
located in Golgi apparatus	IDA IDA: 通过直接分析推断	9852147	GOA
located in Golgi stack	IDA IDA: 通过直接分析推断	9852147	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	12506059	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GALNT2 蛋白结构

Glycos_transf_2

Ricin_B_lectin

0
100
200
300
400
500
571 a.a.

蛋白主名

其他名称

polypeptide N-acetylgalactosaminyltransferase 2

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2

GALNT2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GALNT2	Q10471	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	32296183
种属内	GALNT2	Q10471	MRM3	Homo sapiens	Q9HC36	Y2H Array	32296183
种属内	GALNT2	Q10471	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
种属内	GALNT2	Q10471	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
种属内	GALNT2	Q10471	COQ9	Homo sapiens	O75208	Y2H Array	32296183
种属内	GALNT2	Q10471	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
种属内	GALNT2	Q10471	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
种属内	GALNT2	Q10471	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
种属内	GALNT2	Q10471	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
种属内	GALNT2	Q10471	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
种属内	GALNT2	Q10471	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GALNT2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76355	GALNT2 Protein, Human (HEK293, His)	Q10471-1/NP_004472.1 (K52-Q571)	≥95%

关联疾病

疾病名称

别名

Congenital Disorder Of Glycosylation, Type Iit

CDG2T	Cdg Iit
Cdgiit	Congenital Disorder Of Glycosylation 2t

Methylmalonic Aciduria, Cblb Type

Methylmalonic Aciduria Cblb Type	Methylmalonic Acidemia Cblb Type
Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type	Methylmalonic Acidemia, Cblb Type
Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type	Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type
Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb	Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb
Methylmalonic Aciduria Type Cblb	MMAB
Methylmalonic Aciduria Type B	Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B
Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B	Aciduria, Methylmalonic, Cblb Type
Methylmalonic Acidemia	Methylmalonic Aciduria

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-E70139	UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2		/	否
HY-RS01301	B3GALNT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01316	B4GALNT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05256	GALNT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GALNT2	VGNC	VGNC:29231
Canis familiaris	GALNT2	VGNC	VGNC:41094
Rattus norvegicus	GALNT2	RGD	RGD:1310692
Felis catus	GALNT2	VGNC	VGNC:62450
Macaca mulatta	GALNT2	VGNC	VGNC:72872
Mus musculus	GALNT2	MGD	MGI:894694
Others	GALNT2	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GALNT2 - polypeptide N-acetylgalactosaminyltransferase 2 Gene

关于 GALNT2

功能概要

GALNT2 基因产物(2)

GALNT2 蛋白结构

GALNT2 蛋白互作信息

重组 GALNT2 蛋白

关联疾病

直系同源

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GALNT2 - polypeptide N-acetylgalactosaminyltransferase 2 Gene

关于 GALNT2

功能概要

GALNT2 基因产物(2)

GALNT2 蛋白结构

GALNT2 蛋白互作信息

重组 GALNT2 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z