2. Gene
  3. AMD1 - adenosylmethionine decarboxylase 1 Gene

AMD1 - adenosylmethionine decarboxylase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腺苷甲硫氨酸脱羧酶 1

种属: Homo sapiens

同用名: AMD; SAMDC; ADOMETDC

基因 ID: 262 | 基因类型: protein coding

关于 AMD1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,814,617-110,895,713 (from NCBI)

This gene has 10 transcripts (splice variants) and 256 orthologues. Ubiquitous expression in prostate (RPKM 106.1), bone marrow (RPKM 38.6) and 25 other tissues.

功能概要

该基因编码多胺生物合成中的一种重要中间酶。多胺精胺、亚精胺和腐胺是细胞增殖和肿瘤促进所必需的低分子量脂肪胺。已经鉴定出多个选择性剪接的转录本变体。该基因的假基因存在于染色体 5、6、10、X 和 Y 上。[RefSeq 提供，2013 年 12 月]

This gene encodes an important intermediate Enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

AMD1 基因产物(7)

mRNA Protein Name
NM_001287214.1 NP_001274143.1 S-adenosylmethionine decarboxylase proenzyme isoform 3
NM_001287215.2 NP_001274144.1 S-adenosylmethionine decarboxylase proenzyme isoform 4
NM_001287216.1 NP_001274145.1 S-adenosylmethionine decarboxylase proenzyme isoform 5
NM_001393406.1 NP_001380335.1 S-adenosylmethionine decarboxylase proenzyme isoform 4
NM_001393407.1 NP_001380336.1 S-adenosylmethionine decarboxylase proenzyme isoform 6
NM_001393408.1 NP_001380337.1 S-adenosylmethionine decarboxylase proenzyme isoform 6
NM_001634.6 NP_001625.2 S-adenosylmethionine decarboxylase proenzyme isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AMD1 蛋白结构

SAM_decarbox

SAM_decarbox: Adenosylmethionine decarboxylase (3 - 328)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
蛋白主名 其他名称

S-adenosylmethionine decarboxylase proenzyme

S-adenosylmethionine decarboxylase 1

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 87

DEE87

Epileptic Encephalopathy, Early Infantile, 87

Eiee87

Developmental And Epileptic Encephalopathy, 87

Early Infantile Epileptic Encephalopathy 87
Sleeping Sickness

African Trypanosomiasis

African Sleeping Sickness

Trypanosomiasis, Human East-African

Trypanosomiasis, East African

Trypanosomiasis African

Trypanosomiasis, African

Human African Trypanosomiasis
Trypanosomiasis
Chagas Disease

American Trypanosomiasis

Chagas' Disease

Chagas' Disease With Digestive System Involvement

Chagas' Disease With Nervous System Involvement

Chagas' Disease With Other Organ Involvement

Infection Due To Trypanosoma Cruzi

South American Trypanosomiasis

Chronic Chagas Disease With Digestive System Involvement
Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome

Mental Retardation, X-Linked, Snyder-Robinson Type

Spermine Synthase Deficiency

Srs

Snyder-Robinson Mental Retardation Syndrome

X-Linked Intellectual Disability Snyder-Robinson Type

Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

Snyder-Robinson X-Linked Mental Retardation Syndrome
Secondary Progressive Multiple Sclerosis

Secondary-Progressive Ms

Spms

Multiple Sclerosis, Chronic Progressive

Chronic Progressive Multiple Sclerosis

Multiple Sclerosis, Secondary Progressive
Transient Cerebral Ischemia

Transient Ischemic Attack

Transient Ischemic Attacks

Tia

Tia - Transient Ischaemic Attack

Transient Cerebral Ischaemia

Ischemic Attack, Transient

Intermittent Cerebral Ischemia

Tia - [Transient Ischaemic Attack]

Intermittent Cerebral Ischaemia

Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Retinitis Pigmentosa 61

RP61

Retinitis Pigmentosa, Type 61
Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency

Cox Deficiency

Cytochrome-C Oxidase Deficiency Disease

MC1DN4

Cytochrome-C Oxidase Deficiency

MC4DN1

Mitochondrial Complex I Deficiency, Nuclear Type 4

Complex 4 Mitochondrial Respiratory Chain Deficiency

Complex Iv Deficiency

Mitochondrial Complex 1 Deficiency, Nuclear Type 4

Nuclear Type Mitochondrial Complex I Deficiency 4

Deficiency Of Mitochondrial Respiratory Chain Complex4

MT-C4D

Complex Iv Mitochondrial Respiratory Chain Deficiency

Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-109561 Pegaptanib sodium Inhibitor 98.09% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-19720A Emixustat hydrochloride 99.29% Phase 3
HY-19720 Emixustat Inhibitor 98.00% Phase 3
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132126 SPHINX Inhibitor 99.87% 否
HY-15492 AG-13958 Inhibitor 99.71% 否
HY-15492A AG-13958 (mono(hydrochloride)) Inhibitor / 否
HY-RS00644 AMD1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AMD1 VGNC VGNC:37827
Macaca mulatta AMD1 VGNC VGNC:81021
Bos taurus AMD1 VGNC VGNC:25859
Mus musculus AMD1 MGD MGI:88004
Rattus norvegicus AMD1 RGD RGD:2104
Others AMD1 NCBI
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