Mapk14 - mitogen-activated protein kinase 14 Gene

中文名称：丝裂原活化蛋白激酶 14

种属: Mus musculus

同用名: p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha

基因 ID: 26416 | 基因类型: protein coding

关于 Mapk14

Chromosome 17: 28,910,303-28,967,380 forward strand.GRCm39:CM001010.3

This gene has 10 transcripts (splice variants), 295 orthologues, 19 paralogues and is associated with 49 phenotypes. Ubiquitous expression in spleen adult (RPKM 35.2), thymus adult (RPKM 34.4) and 28 other tissues.

功能概要

该基因编码的蛋白可启动 MAP 激酶活性和 NFAT 蛋白结合活性。涉及多个进程，包括p38MAPK级联；细胞分化的正调控；和骨骼系统发育。作用于多个过程的上游或内部，包括动物器官发育；细胞表面受体信号通路；和细胞分化的正调控。位于几种细胞成分中，包括细胞质；线粒体；和主轴杆。在谷氨酸能突触中活跃。以多种结构表达，包括大脑；早孕;表皮;泌尿生殖系统；和肺。与人 MAPK14（丝裂原活化蛋白激酶 14）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of cell differentiation. Located in several cellular components, including cytosol; mitochondrion; and spindle pole. Is active in glutamatergic synapse. Is expressed in several structures, including brain; early conceptus; epidermis; genitourinary system; and lung. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Mapk14 基因产物(5)

mRNA	Protein	Name
NM_011951.3	NP_036081.1	mitogen-activated protein kinase 14 isoform 1
NM_001168508.1	NP_001161980.1	mitogen-activated protein kinase 14 isoform 2
NM_001168513.1	NP_001161985.1	mitogen-activated protein kinase 14 isoform 3
NM_001168514.1	NP_001161986.1	mitogen-activated protein kinase 14 isoform 3
NM_001357724.1	NP_001344653.1	mitogen-activated protein kinase 14 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MAP kinase activity	IDA IDA: 通过直接分析推断	7914033	MGI
enables MAP kinase activity	IMP IMP: 通过突变表型推断	20551513	MGI
enables NFAT protein binding	IPI IPI: 通过物理相互作用推断	15304486	MGI
enables kinase activity	IDA IDA: 通过直接分析推断	12808090	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	10415025	MGI
enables protein kinase activity	IDA IDA: 通过直接分析推断	10943842	MGI
enables protein serine/threonine kinase activity	EXP EXP: 通过实验结果推断	16364914	MGI
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	18347059	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of D-glucose import	IMP IMP: 通过突变表型推断	19403598	MGI
acts upstream of or within DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	12937170	MGI
acts upstream of or within DNA damage response	IDA IDA: 通过直接分析推断	20212154	MGI
involved in MAPK cascade	IMP IMP: 通过突变表型推断	20551513	MGI
acts upstream of or within angiogenesis	IMP IMP: 通过突变表型推断	10973481	MGI
involved in bone development	IMP IMP: 通过突变表型推断	20551513	MGI
involved in cartilage condensation	IMP IMP: 通过突变表型推断	17202865	MGI
acts upstream of or within cell morphogenesis	IGI IGI: 通过遗传相互作用推断	17686994	MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway	IGI IGI: 通过遗传相互作用推断	18363966	MGI
acts upstream of or within cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	24349514	MGI
acts upstream of or within chondrocyte differentiation	IDA IDA: 通过直接分析推断	17644814	MGI
involved in chondrocyte differentiation	IMP IMP: 通过突变表型推断	17202865	MGI
acts upstream of or within fatty acid oxidation	IMP IMP: 通过突变表型推断	12802337	MGI
acts upstream of or within glucose metabolic process	IMP IMP: 通过突变表型推断	12802337	MGI
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	7914033	MGI
acts upstream of or within lipopolysaccharide-mediated signaling pathway	IDA IDA: 通过直接分析推断	12872135	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	17202865	MGI
involved in osteoblast differentiation	IMP IMP: 通过突变表型推断	20551513	MGI
involved in osteoclast differentiation	IMP IMP: 通过突变表型推断	15304486	MGI
involved in p38MAPK cascade	IDA IDA: 通过直接分析推断	22847234	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	18347059	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	15304486	MGI
acts upstream of or within placenta development	IMP IMP: 通过突变表型推断	21768366	MGI
acts upstream of or within positive regulation of D-glucose import	IMP IMP: 通过突变表型推断	19403598	MGI
acts upstream of or within positive regulation of brown fat cell differentiation	IMP IMP: 通过突变表型推断	23977283	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: 通过遗传相互作用推断	21768366	MGI
acts upstream of or within positive regulation of erythrocyte differentiation	IMP IMP: 通过突变表型推断	10943842	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: 通过突变表型推断	22897442	MGI
involved in positive regulation of myoblast differentiation	IMP IMP: 通过突变表型推断	22847234	MGI
involved in positive regulation of myoblast fusion	IMP IMP: 通过突变表型推断	22847234	MGI
involved in positive regulation of myotube differentiation	IMP IMP: 通过突变表型推断	22847234	MGI
acts upstream of or within positive regulation of protein import into nucleus	IMP IMP: 通过突变表型推断	16954198	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10943842	MGI
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	15767678	MGI
acts upstream of or within protein phosphorylation	IMP IMP: 通过突变表型推断	15937334	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	20212154	MGI
acts upstream of or within regulation of ossification	IDA IDA: 通过直接分析推断	20053668	MGI
involved in regulation of synaptic membrane adhesion	EXP EXP: 通过实验结果推断	17988630	MGI
involved in regulation of synaptic membrane adhesion	IDA IDA: 通过直接分析推断	17988630	MGI
involved in regulation of synaptic membrane adhesion	IEP IEP: 通过表达模式推断	17988630	MGI
involved in regulation of synaptic membrane adhesion	IMP IMP: 通过突变表型推断	17988630	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22847234	MGI
involved in response to dietary excess	IMP IMP: 通过突变表型推断	19948881	MGI
involved in response to insulin	IMP IMP: 通过突变表型推断	19948881	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: 通过直接分析推断	12872135	MGI
acts upstream of or within response to muramyl dipeptide	IDA IDA: 通过直接分析推断	15692051	MGI
acts upstream of or within response to muscle stretch	IMP IMP: 通过突变表型推断	19403598	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: 通过突变表型推断	15890335	MGI
acts upstream of or within stem cell differentiation	IDA IDA: 通过直接分析推断	17644814	MGI
acts upstream of or within striated muscle cell differentiation	IGI IGI: 通过遗传相互作用推断	20160094	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10943842	MGI
acts upstream of or within positive effect tumor necrosis factor production	IMP IMP: 通过突变表型推断	19948881	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10601328	MGI
is active in cytosol	IDA IDA: 通过直接分析推断	21976273	MGI
located in cytosol	IDA IDA: 通过直接分析推断	11884367	MGI
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	17988630	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	17988630	MGI
is active in glutamatergic synapse	IEP IEP: 通过表达模式推断	17988630	MGI
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	17988630	MGI
located in mitochondrion	IDA IDA: 通过直接分析推断	11884367	MGI
located in nucleus	IDA IDA: 通过直接分析推断	10601328	MGI
located in spindle pole	IDA IDA: 通过直接分析推断	15509711	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mapk14 蛋白结构

STKc_p38alpha

0
100
200
300
360 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase 14

MAP kinase 14	MAP kinase p38 alpha
MAPK 14	mitogen-activated protein kinase p38 alpha
p38 MAP kinase alpha	p38 MAPK

目录号	产品名	作用方式	纯度	Phase
HY-10401	VX-702	Inhibitor	99.54%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148063	DB0614		98.80%	否
HY-18874	p38-α MAPK-IN-1	Inhibitor	99.89%	否
HY-148061	DB1113		99.28%	否
HY-RS08108	Mapk14 Mouse Pre-designed siRNA Set A		/	否
HY-RS08107	MAPK14 Human Pre-designed siRNA Set A		/	否
HY-RS08109	Mapk14 Rat Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Mapk14	NCBI	NCBI:1432

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Mapk14 - mitogen-activated protein kinase 14 Gene

关于 Mapk14

功能概要

Mapk14 基因产物(5)

Mapk14 蛋白结构

直系同源

热门区域

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Mapk14 - mitogen-activated protein kinase 14 Gene

关于 Mapk14

功能概要

Mapk14 基因产物(5)

Mapk14 蛋白结构

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z