1. Gene
  2. MAPK14 - mitogen-activated protein kinase 14 Gene

MAPK14 - mitogen-activated protein kinase 14 Gene

中文名称:丝裂原活化蛋白激酶 14

种属: Homo sapiens

同用名: RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA

基因 ID: 1432 | 基因类型: protein coding

关于 MAPK14

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:36,027,808-36,124,214 (from NCBI)

This gene has 9 transcripts (splice variants), 292 orthologues and 19 paralogues. Ubiquitous expression in bone marrow (RPKM 18.5), placenta (RPKM 11.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是 MAP 激酶家族的成员。 MAP 激酶作为多种生化信号的整合点,参与多种细胞过程,如增殖、分化、转录调控和发育。这种激酶被各种环境压力和促炎细胞因子激活。激活需要通过 MAP 激酶激酶 (MKK) 进行磷酸化,或者通过 MAP3K7IP1/TAB1 蛋白与该激酶的相互作用触发自身磷酸化。该激酶的底物包括转录调节因子 ATF2、MEF2C 和 MAX、细胞周期调节因子 CDC25B 和肿瘤抑制因子 p53,这表明该激酶在应激相关转录和细胞周期调节以及基因毒性应激反应中的作用。已经报道了编码不同同种型的该基因的四种可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MAPK14 基因产物(18)

mRNA Protein Name
NM_139013.3 NP_620582.1 mitogen-activated protein kinase 14 isoform 3
XM_011514310.4 XP_011512612.2 mitogen-activated protein kinase 14 isoform X1
XM_047418236.1 XP_047274192.1 mitogen-activated protein kinase 14 isoform X8
NM_139014.3 NP_620583.1 mitogen-activated protein kinase 14 isoform 4
XR_007059211.1
NM_139012.3 NP_620581.1 mitogen-activated protein kinase 14 isoform 2
XM_047418234.1 XP_047274190.1 mitogen-activated protein kinase 14 isoform X4
XR_926065.3
XM_006714998.4 XP_006715061.1 mitogen-activated protein kinase 14 isoform X9
XR_007059210.1
XR_007059209.1
XM_047418237.1 XP_047274193.1 mitogen-activated protein kinase 14 isoform X9
NM_001315.3 NP_001306.1 mitogen-activated protein kinase 14 isoform 1
XM_047418235.1 XP_047274191.1 mitogen-activated protein kinase 14 isoform X5
XM_047418232.1 XP_047274188.1 mitogen-activated protein kinase 14 isoform X2
XM_017010300.3 XP_016865789.1 mitogen-activated protein kinase 14 isoform X6
XM_047418233.1 XP_047274189.1 mitogen-activated protein kinase 14 isoform X3
XM_017010299.3 XP_016865788.1 mitogen-activated protein kinase 14 isoform X7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MAP kinase activity IDA
IDA: 通过直接分析推断
7997261 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23483889 GOA
enables mitogen-activated protein kinase p38 binding IPI
IPI: 通过物理相互作用推断
11035004 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9788880 GOA
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
10391943 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
11532965 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
35857590 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV-B IDA
IDA: 通过直接分析推断
35857590 GOA
involved in cellular response to ionizing radiation IMP
IMP: 通过突变表型推断
20160708 GOA
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
23776175 GOA
involved in cellular response to lipoteichoic acid IMP
IMP: 通过突变表型推断
26649771 GOA
involved in cellular response to vascular endothelial growth factor stimulus IMP
IMP: 通过突变表型推断
18440775 GOA
involved in cellular response to virus IMP
IMP: 通过突变表型推断
25754930 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10838079 GOA
involved in negative regulation of hippo signaling IMP
IMP: 通过突变表型推断
27402810 GOA
involved in p38MAPK cascade IDA
IDA: 通过直接分析推断
10330143 GOA
NOT involved in positive regulation of blood vessel endothelial cell migration IMP
IMP: 通过突变表型推断
18440775 GOA
involved in positive regulation of cyclase activity IMP
IMP: 通过突变表型推断
22027397 GOA
involved in positive regulation of erythrocyte differentiation IMP
IMP: 通过突变表型推断
23483889 GOA
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
24299952 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
25754930 GOA
involved in positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
25754930 GOA
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
20160708 GOA
involved in regulation of cytokine production involved in inflammatory response IDA
IDA: 通过直接分析推断
15251176 GOA
involved in signal transduction in response to DNA damage IMP
IMP: 通过突变表型推断
20160708 GOA
involved in stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
35857590 GOA
involved in stress-activated protein kinase signaling cascade IDA
IDA: 通过直接分析推断
35857590 GOA
involved in stress-induced premature senescence IMP
IMP: 通过突变表型推断
20160708 GOA
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
18440775 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
7535770 GOA
located in nucleus IDA
IDA: 通过直接分析推断
30878395 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MAPK14 蛋白结构

Pkinase

Pkinase: Protein kinase domain (24 - 308)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase 14

CSAID-binding protein

MAP kinase 14

MAP kinase Mxi2

MAP kinase p38 alpha

MAX-interacting protein 2

cytokine suppressive anti-inflammatory drug binding protein

mitogen-activated protein kinase p38 alpha

p38 MAP kinase

p38 mitogen activated protein kinase

p38alpha Exip

stress-activated protein kinase 2A

MAPK14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAPK14 Q16539 DUSP7 Homo sapiens Q16829 33961781
种属内
MAPK14 Q16539 DUSP7 Homo sapiens Q16829 9788880
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644 31515488
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644 25852190
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644 33961781
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644 26496610
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644
TAP
23602568
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644
TAP
23455922
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644 31980649
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644 32707033
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644 35271311
种属内
MAPK14 Q16539 MAPKAPK3 Homo sapiens Q16644
PLA
25241761
种属内
MAPK14 Q16539 PTPRR Homo sapiens Q15256 10601328
种属内
MAPK14 Q16539 PTPRR Homo sapiens Q15256
IF
10601328
种属内
MAPK14 Q16539 MKNK2 Homo sapiens Q9HBH9 33961781
种属内
MAPK14 Q16539 MKNK2 Homo sapiens Q9HBH9
TAP
23602568
种属内
MAPK14 Q16539 DUSP16 Homo sapiens Q9BY84 20936779
种属内
MAPK14 Q16539 ZNHIT1 Homo sapiens O43257
Y2H
18624398
种属内
MAPK14 Q16539 ZNHIT1 Homo sapiens O43257
Y2H
17380123
种属内
MAPK14 Q16539 ZNHIT1 Homo sapiens O43257 17380123
种属内
MAPK14 Q16539 ZNHIT1 Homo sapiens O43257 17380123
种属内
MAPK14 Q16539 EEF1A1 Homo sapiens P68104 31980649
种属内
MAPK14 Q16539 DUSP9 Homo sapiens Q99956 32707033
种属内
MAPK14 Q16539 DUSP9 Homo sapiens Q99956 33961781
种属内
MAPK14 Q16539 DUSP9 Homo sapiens Q99956 21908610
种属内
MAPK14 Q16539 MAP2K6 Homo sapiens P52564 32707033
种属内
MAPK14 Q16539 RB1 Homo sapiens P06400 20871633
种属内
MAPK14 Q16539 MAP2K3 Homo sapiens P46734 31980649
种属内
MAPK14 Q16539 MAP2K3 Homo sapiens P46734 32707033
种属内
MAPK14 Q16539 MAP2K3 Homo sapiens P46734 17255949
种属内
MAPK14 Q16539 MAP2K3 Homo sapiens P46734 33961781
种属内
MAPK14 Q16539 MAP2K3 Homo sapiens P46734
TAP
23602568
种属内
MAPK14 Q16539 ZFP36L1 Homo sapiens Q07352 16189514
种属内
MAPK14 Q16539 MKNK1 Homo sapiens Q9BUB5 32707033
种属内
MAPK14 Q16539 MKNK1 Homo sapiens Q9BUB5
TAP
23602568
种属内
MAPK14 Q16539 MKNK1 Homo sapiens Q9BUB5 33961781
种属内
MAPK14 Q16539 MKNK1 Homo sapiens Q9BUB5 20936779
种属内
MAPK14 Q16539 MKNK1 Homo sapiens Q9BUB5
TAP
23455922
种属内
MAPK14 Q16539 RPS6KA5 Homo sapiens O75582 33961781
种属内
MAPK14 Q16539 RPS6KA4 Homo sapiens O75676 33961781
种属内
MAPK14 Q16539 RPS6KA4 Homo sapiens O75676
Y2H
9792677
种属内
MAPK14 Q16539 RPS6KA4 Homo sapiens O75676 9792677
种属内
MAPK14 Q16539 RPS6KA4 Homo sapiens O75676
TAP
23602568
种属内
MAPK14 Q16539 RPS6KA4 Homo sapiens O75676 31980649
种属内
MAPK14 Q16539 RPS6KA4 Homo sapiens O75676 25852190
种属内
MAPK14 Q16539 MAPK3 Homo sapiens P27361 11238443
种属内
MAPK14 Q16539 MAPK3 Homo sapiens P27361
PLA
23397142
种属内
MAPK14 Q16539 CSNK1D Homo sapiens P48730-2 32814053
种属内
MAPK14 Q16539 CSNK1D Homo sapiens P48730-2 32814053
种属内
MAPK14 Q16539 CSNK1D Homo sapiens P48730-2 32814053
种属内
MAPK14 Q16539 SUPT20H Homo sapiens Q8NEM7
Y2H
21988832
种属内
MAPK14 Q16539 DUSP1 Homo sapiens P28562 20936779
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137 33961781
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137
TAP
23602568
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137
TAP
23455922
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137 31980649
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137 25852190
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137 17255097
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137 32707033
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137 26496610
种属内
MAPK14 Q16539 MAPKAPK2 Homo sapiens P49137 35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MAPK14 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73335 p38 alpha/MAPK14 Protein, Human (Activated, sf9, His) Q16539-2/NP_001306.1 (M1-S360) ≥95%

MAPK14 抗体

目录号 产品名 应用 反应物种
HY-P80776 p38 Antibody (YA696) WB Human, Mouse, Rat, Monkey
HY-P80776A Phospho-p38 (Thr180+Tyr182) Antibody WB, IHC-P, FC, ICC/IF, ELISA Human, Mouse
HY-P80777 p38 Antibody WB, IP Human
HY-P80842 Phospho-p38 (Thr180/Tyr182) Antibody WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Ischemia

Acute Coronary Syndrome

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Ureteral Obstruction
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Trichothiodystrophy 7, Nonphotosensitive

TTD7

Nonphotosensitive Trichothiodystrophy 7

Trichothiodystrophy 7, Non-Photosensitive

Spotted Fever

Spotted Fevers

Spotted Fever Group Rickettsial Disease

Tick-Borne Rickettsioses

Tick-Borne Typhus Nos

Rocky Mountain Spotted Fever

Sao Paulo Fever

Sao Paulo Typhus

Lone Star Spotted Fever

Colombian Spotted Fever

American Spotted Fever

Tick Typhus Due To Rickettsia Rickettsii

Rocky Mountain Tick Fever

Boutonneuse Fever

Mediterranean Tick Fever

Fièvre Boutonneuse

Mediterranean Spotted Fever

Tick Typhus Due To Rickettsia Conorii

African Tick Typhus

Indian Tick Typhus

Kenya Tick Typhus

North Asian Tick Fever

Siberian Tick Typhus

Tick Typhus Due To Rickettsia Siberica

North Asian Spotted Fever

Queensland Tick Typhus

Queensland Fever

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25

CMH25

Cardiomyopathy, Hypertrophic, 25

Cardiomyopathy Familial Hypertrophic 25

Cardiomyopathy, Familial Hypertrophic 25

Cardiomyopathy, Hypertrophic, Type 25

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Alexander Disease

Alexander'S Disease

ALXDRD

Alexanders Leukodystrophy

Axd

Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia

Alx

Demyelinogenic Leukodystrophy

Dysmyelinogenic Leukodystrophy

Fibrinoid Degeneration Of Astrocytes

Leukodystrophy With Rosenthal Fibers

Alexander Disease Type Ii

Axd Type Ii

Alexander Disease Type I

Axd Type I

Alexanders Disease

Alexander'S Leukodystrophy

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease

COPD

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Chronic Obstructive Lung Disease

Chronic Obstructive Airway Disease

Pulmonary Disease, Chronic Obstructive, Susceptibility To

Cold

Severe Early-Onset Chronic Obstructive Pulmonary Disease

Pulmonary Disease Chronic Obstructive

Pulmonary Disease, Obstructive, Chronic, Susceptibility To

Chronic Obstructive Pulmonary Disease Of Horses

Common Cold

Upper Respiratory Infections

Copd - [Chronic Obstructive Pulmonary Disease]

Coad - [Chronic Obstructive Airways Disease]

Cold - [Chronic Obstructive Lung Disease]

Chronic Airway Disease Nos

Chronic Airways Limitation, Unspecified

Chronic Obstructed Airway, Unspecified

Chronic Obstructive Airway Disease, Unspecified

Chronic Obstructive Airway, Unspecified

Obstructive Lung Disease Nos

Chronic Obstructive Lung Disease Nos

Chronic Obstructive Lung Nos

Obstructive Pulmonary Disease Nos

Exacerbation Copd Nos

Acute Exacerbation Copd

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye

Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Proteasome-Associated Autoinflammatory Syndrome 1

Jmp Syndrome

Nakajo-Nishimura Syndrome

Nkjo

Autoinflammation, Lipodystrophy, And Dermatosis Syndrome

Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms

Nakajo Syndrome

PRAAS1

Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome

Candle

Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy

Aldd

Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy

Nakajo Nishimura Syndrome

Amyotrophy Fat Tissue Anomaly

Japanese Autoinflammatory Syndrome With Lipodystrophy

Jasl

Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy

Nns

Nodular Erythema With Digital Changes

Secondary Hypertrophic Osteoperiostosis With Pernio

Inflammation

Glioma
Glioblastoma Mesenchymal Subtype
Anthrax Disease

Anthrax

Ragpicker'S Disease

Black Baine

Malignant Edema

Malignant Pustule

Siberian Plague

Wool Sorter'S Disease

Gas Gangrene

Cutaneous Anthrax

Anthrax Infection

Splenic Fever

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

Chlamydia

Chlamydial Infection

Chlamydia Trachomatis Infectious Disease

Chlamydial Disease

Chlamydia Infections

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Disease, Susceptibility To

Coronary Artery Anomaly

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAPK14 RGD RGD:70496
Mus musculus MAPK14 MGD MGI:1346865
Canis familiaris MAPK14 VGNC VGNC:42995
Bos taurus MAPK14 VGNC VGNC:31216
Felis catus MAPK14 VGNC VGNC:68167
Macaca mulatta MAPK14 VGNC VGNC:74645
Others MAPK14 NCBI