Aak1 - AP2 associated kinase 1 Gene

中文名称：AP2 相关激酶1

种属: Mus musculus

同用名: Gm38495; mKIAA1048; 9630042K20; D6Ertd245e; 5530400K14Rik

关于 Aak1

功能概要

预计该基因编码的蛋白可启动 AP-2 适配器复合体绑定活动； Notch结合活性；和蛋白丝氨酸/苏氨酸激酶活性。预计参与多个过程，包括Notch信号通路的正调控；蛋白质稳定性；和网格蛋白依赖性内吞作用的调节。预测作用于内吞作用和磷酸化作用的上游或内部。预计位于电池前缘和终端bouton。预计是网格蛋白复合物的一部分。预计在细胞质中有活性。在颅神经节中表达；背根神经节；视网膜核层；和端脑。与人类 AAK1（AP2 相关激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable AP-2 adaptor complex binding activity; Notch binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of Notch signaling pathway; protein stabilization; and regulation of clathrin-dependent endocytosis. Predicted to act upstream of or within endocytosis and phosphorylation. Predicted to be located in cell leading edge and terminal bouton. Predicted to be part of clathrin complex. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; dorsal root ganglion; retina nuclear layer; and telencephalon. Orthologous to human AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]