Tlr4 - toll-like receptor 4 Gene

中文名称：Toll样受体 4

种属: Rattus norvegicus

关于 Tlr4

功能概要

该基因编码的蛋白可启动脂多糖结合活性和磷脂酰肌醇 3-激酶结合活性。涉及多个过程，包括检测与疼痛感觉相关的刺激；免疫反应调节信号通路；和对类固醇激素的反应。位于细胞表面和细胞质中。与膜筏共定位。用于研究多种疾病，包括颈动脉狭窄；回肠炎;神经病（多发）；肥胖;和肾纤维化。多种疾病的生物标志物，包括肾衰竭（多种）；胰腺炎（多发性）；围产期坏死性小肠结肠炎；牙髓炎;和坐骨神经病。该基因的人类直系同源物与多种疾病有关，包括过敏性接触性皮炎（多种）；动脉疾病（多发性）；自身免疫性疾病（多种）；眼病（多发）；和肺部疾病（多种）。与人类 TLR4（toll 样受体 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables lipopolysaccharide binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; immune response-regulating signaling pathway; and response to steroid hormone. Located in cell surface and cytoplasm. Colocalizes with membrane raft. Used to study several diseases, including carotid stenosis; ileitis; neuropathy (multiple); obesity; and renal fibrosis. Biomarker of several diseases, including kidney failure (multiple); pancreatitis (multiple); perinatal necrotizing enterocolitis; pulpitis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4). [provided by Alliance of Genome Resources, Apr 2022]