2. Anti-infection Immunology/Inflammation NF-κB Apoptosis Autophagy
  3. Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic
  4. Physcion

Physcion  (Synonyms: 大黄素甲醚; Parietin; Rheochrysidin)

目录号: HY-N0108 纯度: 99.10%
COA 产品使用指南 技术支持

Physcion (Parietin) 是从中药大黄中得到的蒽醌类物质，是具有口服有效性和血脑屏障透过性的 6-磷酸葡萄糖酸脱氢酶 (6-phosphogluconate dehydrogenase) 抑制剂，IC50 和 Kd 值分别为 38.5 μM 和 26.0 μM。同时，Physcion 也是 TLR4/NF-kB 信号通路抑制剂，具有抗炎、抗菌、抗癌作用，可诱导癌细胞凋亡 (Apoptosis) 和自噬 (Autophagy)。

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Physcion Chemical Structure

Physcion Chemical Structure

CAS No. : 521-61-9

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规格 价格 是否有货 数量
10 mM * 1 mL in DMF ￥343
In-stock
5 mg ￥312
In-stock
10 mg ￥500
In-stock
25 mg ￥1000
In-stock
50 mg ￥1750
In-stock
100 mg ￥3000
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Physcion:

Physcion 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells[1][2][3][4][5].

IC50 & Target

TLR4

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
A549 IC50
1.5 μM
Compound: 80
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
HCT-116 IC50
19 μM
Compound: 2
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay
Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay
[PMID: 17949858]
HepG2 IC50
77.3 μM
Compound: 2
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay
[PMID: 17949858]
HT-29 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
HUVEC IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
MCF7 IC50
> 100 μg/mL
Compound: 6
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 26995526]
NCI-H157 IC50
3 μM
Compound: 80
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
体外研究
(In Vitro)

Physcion (10 或 20 μM，48 小时) 诱导人鼻咽癌 (CNE2 细胞) 的细胞凋亡和自噬[2]。
Physcion (10-40 μM，24 小时) 在 SH-SY5Y 细胞中减弱了 OGD/R (oxygen-glucose deprivation/reperfusion) 诱导的神经元损伤及炎症反应[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Physcion 相关抗体:

Apoptosis Analysis[2]

Cell Line: The nasopharyngeal carcinoma cell line CNE2
Concentration: 10 or 20 μM
Incubation Time: 48 h
Result: Induced apoptosis in CNE2 cells in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: The nasopharyngeal carcinoma cell line CNE2
Concentration: 10 or 20 μM
Incubation Time: 48 h
Result: Significantly increased the level of LC3B-II, which means physcion induced autophagy in CNE2 cells.

Western Blot Analysis[3]

Cell Line: Oxygen-glucose deprivation/reperfusion (OGD/R)-induced SH-SY5Y cells
Concentration: 40 μM
Incubation Time: 24 h
Result: Significantly reversed the OGD/R-induced upregulation of TLR4, p-p65, and p-IκB expression.
体内研究
(In Vivo)

Physcion (20 or 40 mg/kg，口服，每日一次共 7 天) 通过抑制 TLR4/NF-kB 信号通路，在脑缺血再灌注诱导的 SD 大鼠模型中发挥神经保护作用[3]。
Physcion (4 或 9 mg/kg，口服，每日一次共 6 天) 可在 SPF 鸡中有效减轻由 Chlamydia psittaci 6 BCE 引起的感染症状[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ischemia-reperfusion (I/R)-induced focal cerebral ischemia model in SD rats[3]
Dosage: 20 or 40 mg/kg
Administration: Oral gavage (p.o.), once daily for 7 days
Result: Significantly reduced the brain water content and the NSS (Neurological Severity Score) in I/R rats, compared to I/R group.
Obviously decreased areas of infarction compared to I/R group.
Animal Model: SPF chickens (21 days old) infected intra-laryngeally with Chlamydia psittaci 6 BCE[4]
Dosage: 4 or 9 mg/kg
Administration: Oral gavage (p.o.), once daily for 6 days
Result: Dose-dependently alleviated respiratory distress, air sac and lung lesions, and bacterial load in the spleen in infected chickens.
分子量

284.26

Formula

C16H12O5
CAS 号
性状

固体

颜色

Yellow to orange

中文名称

大黄素甲醚
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3.33 mg/mL (11.71 mM; ultrasonic and warming and adjust pH to 9 with NaOH and heat to 60°C; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

THF 中的溶解度 : 2.5 mg/mL (8.79 mM; 超声助溶 (<60°C))

DMF 中的溶解度 : 1 mg/mL (3.52 mM; 超声助溶)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.10%

COA (288 KB) HNMR (241 KB) RP-HPLC (228 KB) MS (206 KB)

产品使用指南 (1538 KB)
参考文献

Physcion 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF / THF / DMSO 1 mM 3.5179 mL 17.5895 mL 35.1791 mL 87.9477 mL
THF / DMSO 5 mM 0.7036 mL 3.5179 mL 7.0358 mL 17.5895 mL
DMSO 10 mM 0.3518 mL 1.7590 mL 3.5179 mL 8.7948 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Physcion521-61-9Parietin Rheochrysidin大黄素甲醚BacterialToll-like Receptor (TLR)NF-κBApoptosisAutophagyAntibioticNuclear factor-κBNuclear factor-kappaBIschemia-reperfusion (I/R)-induced SD rats modelNasopharyngeal carcinoma cell line CNE2anti-inflammatoryanti-microbialanti-cancerInhibitorinhibitorinhibit

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