Tlr4 - toll-like receptor 4 Gene

中文名称：Toll样受体 4

种属: Mus musculus

同用名: Lps; Ly87; Ran/M1; Rasl2-8

关于 Tlr4

功能概要

该基因属于进化上保守的 Toll 样受体家族，其成员是参与先天免疫的 1 型跨膜蛋白。 Toll 样受体的特征在于在配体识别中起作用的细胞外富含亮氨酸的重复结构域和对信号转导至关重要的细胞内 toll/白细胞介素 1 受体样结构域。由该基因编码的受体通过合成促炎细胞因子和趋化因子介导对细菌脂多糖的先天免疫反应，脂多糖是革兰氏阴性菌外膜的主要成分。此外，这种蛋白质可以识别来自革兰氏阴性和革兰氏阳性细菌的其他病原体以及病毒成分。与对照组相比，缺乏该基因的小鼠表现出许多与免疫反应相关的表型，包括对细菌脂多糖的低反应性和呼吸道合胞病毒水平升高。 [RefSeq 提供，2015 年 9 月]

This gene belongs to the evolutionarily-conserved Toll-like Receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to Bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize Other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to Bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]