1. Gene
  2. Sirt6 - sirtuin 6 Gene

Sirt6 - sirtuin 6 Gene

中文名称:沉默信息调节因子 2 相关酶类 6

种属: Rattus norvegicus

基因 ID: 299638 | 基因类型: protein coding

关于 Sirt6

Primary_assembly 7: 8,082,364-8,098,914 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 13 phenotypes.

功能概要

该基因编码的蛋白可启动蛋白质脱乙酰酶活性。参与参与心脏形态发生和对营养水平反应的胚胎后心肌细胞生长。位于细胞质和细胞核中。非酒精性脂肪肝的生物标志物;肥胖;和短暂性脑缺血。与人类 SIRT6(sirtuin 6)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein deacetylase activity. Involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis and response to nutrient levels. Located in cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (Sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]

Sirt6 基因产物(1)

mRNA Protein Name
NM_001031649.1 NP_001026819.1 NAD-dependent protein deacetylase sirtuin-6
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22335191 RGD
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
22335191 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
30894089 RGD
involved in cellular response to endothelin IEP
IEP: 通过表达模式推断
30894089 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
30894089 RGD
involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis IMP
IMP: 通过突变表型推断
22335191 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
22321393 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

NAD-dependent protein deacetylase sirtuin-6

NAD-dependent deacetylase sirtuin-6

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirt6 NCBI NCBI:51548