1. Gene
  2. OLR1 - oxidized low density lipoprotein receptor 1 Gene

OLR1 - oxidized low density lipoprotein receptor 1 Gene

中文名称:氧化低密度脂蛋白受体 1

种属: Homo sapiens

同用名: LOX1; LOXIN; SLOX1; CLEC8A; SCARE1

基因 ID: 4973 | 基因类型: protein coding

关于 OLR1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,158,301-10,176,266 (from NCBI)

This gene has 11 transcripts (splice variants), 368 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in placenta (RPKM 50.3), lung (RPKM 32.5) and 5 other tissues.

功能概要

该基因编码属于 C 型凝集素超家族的低密度脂蛋白受体。该基因通过环 AMP 信号通路进行调节。编码的蛋白质结合、内化和降解氧化的低密度脂蛋白。该蛋白可能参与 Fas 诱导的细胞凋亡的调节。这种蛋白质可能起到清道夫受体的作用。该基因的突变与动脉粥样硬化、心肌梗塞的风险有关,并可能改变阿尔茨海默氏病的风险。交替剪接导致多个转录变体。[RefSeq 提供,2010 年 2 月]

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced Apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

OLR1 基因产物(3)

mRNA Protein Name
NM_001172632.2 NP_001166103.1 oxidized low-density lipoprotein receptor 1 isoform 2
NM_001172633.2 NP_001166104.1 oxidized low-density lipoprotein receptor 1 isoform 3
NM_002543.4 NP_002534.1 oxidized low-density lipoprotein receptor 1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15939022 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24846140 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OLR1 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (164 - 266)

  • 0
  • 100
  • 200
  • 273 a.a.
蛋白主名 其他名称

oxidized low-density lipoprotein receptor 1

C-type lectin domain family 8 member A

OLR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OLR1 P78380 TCP1 Homo sapiens P17987
Pull Down
24846140
种属内
OLR1 P78380 TCP1 Homo sapiens P17987
Anti Bait CoIP
24846140
种属内
OLR1 P78380 CCT4 Homo sapiens P50991
Anti Bait CoIP
24846140
种属内
OLR1 P78380 CCT4 Homo sapiens P50991
Pull Down
24846140
种属内
OLR1 P78380 HSPA1L Homo sapiens P34931
Fluorescence
15792802
种属内
OLR1 P78380 q9bu08_human Homo sapiens Q9BU08
Pull Down
24846140
种属内
OLR1 P78380 OLR1 Homo sapiens P78380
X-Ray Diffraction
15939022
种属内
OLR1 P78380 CCT3 Homo sapiens P49368
Pull Down
24846140
种属内
OLR1 P78380 OLR1 Homo sapiens P78380
Solution Sedimentation
15939022
种属内
OLR1 P78380 CCT6A Homo sapiens P40227
Pull Down
24846140
种属内
OLR1 P78380 CCT7 Homo sapiens Q99832
Pull Down
24846140
种属内
OLR1 P78380 OLR1 Homo sapiens P78380
Comigration in SDS
15939022
种属内
OLR1 P78380 OLR1 Homo sapiens P78380
GMS
19664054
种属内
OLR1 P78380 F5 Homo sapiens P12259
Anti Tag CoIP
28514442
种属内
OLR1 P78380 F5 Homo sapiens P12259
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 OLR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71180 OLR1 Protein, Human (HEK293, His) P78380-1 (S61-Q273) ≥95%

关联疾病

疾病名称 别名
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Atherosclerosis Susceptibility

Atherosclerosis

Atherosclerosis, Susceptibility To

ATHS

Atherogenic Lipoprotein Phenotype

Alp

Arteriosclerosis

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Exfoliation Syndrome

Pseudoexfoliation Glaucoma

Pseudoexfoliation Syndrome

Exfoliation Syndrome, Susceptibility To

XFS

Exfoliation Glaucoma

Xfg

Pseudoexfoliation Of The Lens

Pexg

Pexs

Exfoliative Syndrome

Glaucoma Capsulare

Pex

Pseudo-Exfoliation Syndrome

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Diabetes Mellitus

Diabetes

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Aortic Atherosclerosis

Atherosclerosis Of Aorta

Aorta Atheroma

Aorta Calcification

Aorta Arteriosclerosis

Aortic Degeneration

Aortic Calcification

Aortic Atheroma

Aortic Arteriosclerotic Disease

Aortic Arteriosclerosis

Aorta Sclerosis

Aorta Degeneration

Atheromatous Aortic

Calcified Aortic Stenosis

Atheromatous Aorta

Arteriosclerotic Aortitis

Arteriosclerotic Aortic Stenosis

Arteriosclerotic Aorta Disease

Aortic Sclerosis

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta OLR1 VGNC VGNC:75583
Mus musculus OLR1 MGD MGI:1261434
Bos taurus OLR1 VGNC VGNC:32427
Rattus norvegicus OLR1 RGD RGD:620515
Canis familiaris OLR1 VGNC VGNC:44120
Felis catus OLR1 VGNC VGNC:68624
Macaca fascicularis OLR1 NCBI NCBI:102117699
Others OLR1 NCBI