1. Gene
  2. OGFOD1 - 2-oxoglutarate and iron dependent oxygenase domain containing 1 Gene

OGFOD1 - 2-oxoglutarate and iron dependent oxygenase domain containing 1 Gene

中文名称:含 2-氧戊二酸和铁依赖性加氧酶结构域, 1

种属: Homo sapiens

同用名: TPA1

基因 ID: 55239 | 基因类型: protein coding

关于 OGFOD1

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,451,524-56,479,104 (from NCBI)

This gene has 11 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in adrenal (RPKM 10.6), esophagus (RPKM 9.7) and 25 other tissues.

功能概要

启用肽基脯氨酸 3-双加氧酶活性。参与多个过程,包括肽基-脯氨酸羟基化;翻译终止的调节;和应力颗粒组装。位于细胞质应激颗粒;胞质溶胶;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OGFOD1 基因产物(8)

mRNA Protein Name
NM_001324357.2 NP_001311286.1 prolyl 3-hydroxylase OGFOD1 isoform 2
NM_001324358.2 NP_001311287.1 prolyl 3-hydroxylase OGFOD1 isoform 3
NM_001324359.1 NP_001311288.1 prolyl 3-hydroxylase OGFOD1 isoform 4
NM_001324360.2 NP_001311289.1 prolyl 3-hydroxylase OGFOD1 isoform 4
NM_001324361.1 NP_001311290.1 prolyl 3-hydroxylase OGFOD1 isoform 3
NM_001324362.1 NP_001311291.1 prolyl 3-hydroxylase OGFOD1 isoform 5
NM_001324363.2 NP_001311292.1 prolyl 3-hydroxylase OGFOD1 isoform 6
NM_018233.4 NP_060703.3 prolyl 3-hydroxylase OGFOD1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidyl-proline 3-dioxygenase activity EXP
EXP: 通过实验结果推断
24550447 GOA
enables peptidyl-proline 3-dioxygenase activity IDA
IDA: 通过直接分析推断
24550462 GOA
enables peptidyl-proline dioxygenase activity IDA
IDA: 通过直接分析推断
24550447 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell population proliferation IMP
IMP: 通过突变表型推断
24550447 GOA
involved in peptidyl-proline hydroxylation IDA
IDA: 通过直接分析推断
24550447 GOA
involved in protein hydroxylation IDA
IDA: 通过直接分析推断
24550447 GOA
involved in regulation of translational termination IMP
IMP: 通过突变表型推断
24550447 GOA
involved in stress granule assembly IMP
IMP: 通过突变表型推断
24550447 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic stress granule IMP
IMP: 通过突变表型推断
24550447 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OGFOD1 蛋白结构

2OG-FeII_Oxy_3

2OG-FeII_Oxy_3: 2OG-Fe(II) oxygenase superfamily (145 - 238)

Ofd1_CTDD

Ofd1_CTDD: Oxoglutarate and iron-dependent oxygenase degradation C-term (262 - 520)

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  • 542 a.a.
蛋白主名 其他名称

prolyl 3-hydroxylase OGFOD1

2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

OGFOD1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OGFOD1 Q8N543 FEM1A Homo sapiens Q9BSK4
Validated Y2H
32296183
种属内
OGFOD1 Q8N543 FEM1A Homo sapiens Q9BSK4
Y2H Array
32296183
种属内
OGFOD1 Q8N543 FEM1A Homo sapiens Q9BSK4
Y2H Prey Pooling
32296183
种属内
OGFOD1 Q8N543 RPS23 Homo sapiens P62266
Y2H Array
32296183
种属内
OGFOD1 Q8N543 RPS23 Homo sapiens P62266
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intracranial Chondrosarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus OGFOD1 RGD RGD:1308848
Macaca mulatta OGFOD1 VGNC VGNC:75459
Bos taurus OGFOD1 VGNC VGNC:32408
Mus musculus OGFOD1 MGD MGI:2442978
Felis catus OGFOD1 VGNC VGNC:63954
Canis familiaris OGFOD1 VGNC VGNC:44105