SH3RF1 - SH3 domain containing ring finger 1 Gene

中文名称：含 SH3 结构域的无名指 1

种属: Homo sapiens

同用名: POSH; RNF142; SH3MD2

关于 SH3RF1

功能概要

该基因编码的蛋白质包含一个 N 末端环指、四个 SH3 结构域和一个与 Rho GTPase Rac 结合有关的区域。通过无名指，编码的蛋白质已被证明可以作为一种泛素-蛋白质连接酶参与跨高尔基体网络中的蛋白质分选。编码的蛋白质还可以作为 c-Jun N 末端激酶信号通路的支架，促进功能性信号模块的形成。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein Ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]