2. Gene
  3. Phgdh - phosphoglycerate dehydrogenase Gene

Phgdh - phosphoglycerate dehydrogenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸甘油酸脱氢酶

种属: Rattus norvegicus

基因 ID: 58835 | 基因类型: protein coding

关于 Phgdh

Primary_assembly 2: 185,906,966-185,935,944 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 213 orthologues, 7 paralogues and is associated with 11 phenotypes. Biased expression in Kidney (RPKM 314.9), Thymus (RPKM 211.1) and 9 other tissues.

功能概要

该基因编码的蛋白可启动磷酸甘油酸脱氢酶活性。预测参与丝氨酸家族氨基酸的生物合成过程。预计在几个过程的上游或内部起作用，包括 G1 到 G0 的转换；细胞氨基酸代谢过程；和神经系统发育。该基因的人类直系同源物与 Neu-Laxova 综合征 1 有关； PHGDH 缺乏症；和氨基酸代谢紊乱。与人 PHGDH（磷酸甘油酸脱氢酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphoglycerate dehydrogenase activity. Predicted to be involved in serine family amino acid biosynthetic process. Predicted to act upstream of or within several processes, including G1 to G0 transition; cellular amino acid metabolic process; and nervous system development. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Phgdh 基因产物(1)

mRNA Protein Name
NM_031620.2 NP_113808.1 D-3-phosphoglycerate dehydrogenase
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphoglycerate dehydrogenase activity IDA
IDA: 通过直接分析推断
9163325 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Phgdh 蛋白结构

PGDH_4

PGDH_4: cd12173 (7 - 309)

PGDH_inter

PGDH_inter: cl44735 (329 - 406)

  • 0
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  • 533 a.a.
蛋白主名 其他名称

D-3-phosphoglycerate dehydrogenase

3-PGDH

3-phosphoglycerate dehydrogenase

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101966 NCT-503 99.85% 否
HY-100012 CBR-5884 99.02% 否
HY-141412 D-(-)-3-Phosphoglyceric acid disodium Inhibitor ≥98.0% 否
HY-117240 NCT-502 99.72% 否
HY-123269 PKUMDL-WQ-2101 Inhibitor 99.94% 否
HY-126253 BI-4916 98.55% 否
HY-126254 BI-4924 99.55% 否
HY-148570 PHGDH-IN-3 Inhibitor 98.99% 否
HY-121733 PHGDH-inactive 99.93% 否
HY-123418 PKUMDL-WQ-2201 Inhibitor 98.72% 否
HY-RS10433 Phgdh Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-145860 PHGDH-IN-2 / 否
HY-RS10432 PHGDH Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10434 Phgdh Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-125273 DNS-pE / 否
HY-160252 PHGDH-IN-4 Inhibitor / 否
HY-161456 PHGDH-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Phgdh NCBI NCBI:26227
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