Cxcr4 - C-X-C motif chemokine receptor 4 Gene

中文名称：CXC 基序趋化因子受体 4

种属: Rattus norvegicus

基因 ID: 60628 | 基因类型: protein coding

关于 Cxcr4

Primary_assembly 13: 40,077,976-40,081,883 reverse strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 285 orthologues, 24 paralogues and is associated with 54 phenotypes. Biased expression in Thymus (RPKM 542.4), Lung (RPKM 351.9) and 8 other tissues.

功能概要

该基因编码的蛋白可启动小分子结合活性。涉及多个过程，包括检测与疼痛感觉相关的刺激；内皮发育；和神经系统发育。位于核内体；核;和质膜。用于研究肺动脉高压和颞叶癫痫。该基因的人类直系同源物与 WHIM 综合征有关；血液系统癌症（多发性）；白细胞减少症;骨质疏松症；和胰腺癌。与人 CXCR4（CXC 基序趋化因子受体 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables small molecule binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; endothelium development; and nervous system development. Located in endosome; nucleus; and plasma membrane. Used to study pulmonary hypertension and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic Cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif Chemokine Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr4 基因产物(1)

mRNA	Protein	Name
NM_022205.3	NP_071541.2	C-X-C chemokine receptor type 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables small molecule binding	IMP IMP: 通过突变表型推断	21294880	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cardiac muscle contraction	IMP IMP: 通过突变表型推断	17010372	RGD
involved in cell migration	IMP IMP: 通过突变表型推断	15358596	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	20613717	RGD
involved in detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: 通过突变表型推断	27760212	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: 通过突变表型推断	27760212	RGD
involved in endothelial cell differentiation	IMP IMP: 通过突变表型推断	24955809	RGD
involved in endothelial tube morphogenesis	IMP IMP: 通过突变表型推断	24955809	RGD
involved in epithelial cell development	IMP IMP: 通过突变表型推断	15358596	RGD
involved in neurogenesis	IMP IMP: 通过突变表型推断	18434527	RGD
involved in neuron migration	IDA IDA: 通过直接分析推断	12401342	RGD
involved in neuron migration	IMP IMP: 通过突变表型推断	15048928	RGD
involved in neuron recognition	IEP IEP: 通过表达模式推断	12431218	RGD
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	24924806	RGD
involved in positive regulation of chemotaxis	IMP IMP: 通过突变表型推断	30221695	RGD
involved in positive regulation of dendrite extension	IMP IMP: 通过突变表型推断	28104461	RGD
involved in positive regulation of mesenchymal stem cell migration	IMP IMP: 通过突变表型推断	24924806	RGD
involved in positive regulation of neurogenesis	IMP IMP: 通过突变表型推断	28104461	RGD
involved in positive regulation of vascular wound healing	IMP IMP: 通过突变表型推断	24955809	RGD
involved in regulation of calcium ion transport	IMP IMP: 通过突变表型推断	12864967	RGD
involved in regulation of chemotaxis	IMP IMP: 通过突变表型推断	15358596	RGD
involved in regulation of programmed cell death	IMP IMP: 通过突变表型推断	14550764	RGD
involved in regulation of viral process	IDA IDA: 通过直接分析推断	9060691	RGD
involved in response to activity	IEP IEP: 通过表达模式推断	22140095	RGD
involved in response to organic cyclic compound	IMP IMP: 通过突变表型推断	21294880	RGD
involved in response to tacrolimus	IPI IPI: 通过物理相互作用推断	24912495	RGD
involved in response to ultrasound	IEP IEP: 通过表达模式推断	25181476	RGD
involved in telencephalon cell migration	IMP IMP: 通过突变表型推断	16971524	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endosome	IDA IDA: 通过直接分析推断	16952464	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cxcr4 蛋白结构

CXCR4_N

7tmA_CXCR4

0
100
200
300
349 a.a.

蛋白主名

其他名称

C-X-C chemokine receptor type 4

CXC chemokine receptor	CXC-R4
CXCR-4	LESTR
SDF-1 receptor	chemokine (C-X-C motif) receptor 4
chemokine receptor (LCR1)	fusin
leukocyte-derived seven transmembrane domain receptor	stromal cell-derived factor 1 receptor

相关产品

Approval

生物活性分子 (5)

目录号	产品名	作用方式	纯度	是否罕见病
HY-10046	Plerixafor	Antagonist	99.90%	是
HY-50912	Plerixafor octahydrochloride	Antagonist	99.09%	是
HY-50101A	Mavorixafor trihydrochloride	Antagonist	99.75%	是
HY-50101C	Mavorixafor hydrochloride	Antagonist	/	否
HY-50101	Mavorixafor	Antagonist	/	否

Clinical Phase

生物活性分子 (7)

目录号	产品名	作用方式	纯度	Phase
HY-P0171	Motixafortide	Antagonist	99.88%	Phase 3
HY-P1682A	Balixafortide TFA	Antagonist	99.78%	Phase 3
HY-P1682	Balixafortide	Antagonist	/	Phase 3
HY-12488	LY2510924	Inhibitor	99.73%	Phase 2
HY-19867A	Burixafor hydrobromide	Antagonist	≥98.0%	Phase 2
HY-114244	USL311	Antagonist	99.97%	Phase 2
HY-13696	MSX-122	Antagonist	98.92%	Phase 1

抗体抑制剂 (1)

目录号	产品名	作用方式	纯度	Phase
HY-P99272	Ulocuplumab	Antagonist	99.90%	Phase 3

Pre-clinical Phase

生物活性分子 (43)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0011	Baohuoside I	Inhibitor	99.96%	否
HY-111793A	NUCC-390 dihydrochloride	Agonist	99.05%	否
HY-101458A	IT1t dihydrochloride	Antagonist	99.77%	否
HY-P1102	TC14012	Modulator	98.92%	否
HY-15478	WZ811	Antagonist	99.80%	否
HY-15971	AMD 3465 hexahydrobromide	Antagonist	≥98.0%	否
HY-P3612	CTCE-0214	Agonist	98.94%	否
HY-P1103	CTCE-9908	Antagonist	99.47%	否
HY-P1104A	FC131 TFA	Antagonist	99.89%	否
HY-P7061A	ALX 40-4C Trifluoroacetate	Inhibitor	96.65%	否
HY-15971A	AMD 3465	Antagonist	99.59%	否
HY-112709	LIT-927		99.86%	否
HY-103009	MSX-127	Antagonist	99.68%	否
HY-111793	NUCC-390	Agonist	98.40%	否
HY-P1104	FC131	Antagonist	/	否
HY-P4111	Peptide R	Antagonist	/	否
HY-122058A	KRH-3955 hydrochloride	Antagonist	/	否
HY-P4111A	Peptide R TFA	Antagonist	98.34%	否
HY-101458	IT1t	Antagonist	/	否
HY-P10415	EPI-X4	Antagonist	98.80%	否
HY-103010	MSX-130	Antagonist	98.00%	否
HY-P7061	ALX 40-4C	Inhibitor	/	否
HY-P10429	RCP168	Antagonist	/	否
HY-161735	CXCR4-IN-3	Inhibitor	/	否
HY-144285	CXCR4 antagonist 4	Antagonist	/	否
HY-P1103A	CTCE-9908 TFA	Antagonist	/	否
HY-115493	TIQ-15	Antagonist	/	否
HY-147808	CXCR4 antagonist 7	Antagonist	/	否
HY-147979	CXCR4 antagonist 9	Antagonist	/	否
HY-146053	CXCR4 modulator-1	Modulator	/	否
HY-144286	CXCR4 antagonist 3	Inhibitor	/	否
HY-146401	CXCR4 antagonist 6	Antagonist	/	否
HY-129094	ICT5040	Antagonist	/	否
HY-147978	CXCR4 antagonist 8	Antagonist	/	否
HY-146413	HF50731	Antagonist	/	否
HY-P1102A	TC14012 TFA	Modulator	/	否
HY-136437	CXCR4 antagonist 1	Antagonist	/	否
HY-146372	CXCR4 antagonist 5	Antagonist	/	否
HY-168095	CXCR4 antagonist 10	Inhibitor	/	否
HY-162632	Hit 14	Inhibitor	/	否
HY-146054	CXCR4 modulator-2	Modulator	/	否
HY-123819	KRH-1636	Antagonist	/	否
HY-P0172	ATI-2341	Agonist	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Cxcr4	NCBI	NCBI:7852

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