2. Gene
  3. Sirt2 - sirtuin 2 Gene

Sirt2 - sirtuin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：沉默信息调节因子 2 相关酶类 2

种属: Mus musculus

同用名: Sir2l; SIR2L2; 5730427M03Rik

基因 ID: 64383 | 基因类型: protein coding

关于 Sirt2

Chromosome 7: 28,466,160-28,488,086 forward strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 187 orthologues, 6 paralogues and is associated with 24 phenotypes. Ubiquitous expression in testis adult (RPKM 56.8), cerebellum adult (RPKM 53.7) and 28 other tissues.

功能概要

该基因编码的蛋白可启动 β-微管蛋白结合活性；组蛋白脱乙酰酶活性；和微管蛋白脱乙酰酶活性。参与多个过程，包括细胞周期过程的正调控；蛋白质去乙酰化； RNA 聚合酶 II 对转录的调控。作用于组蛋白去乙酰化的上游或内部； NLRP3 炎性体复合物组装的负调控；和脂肪细胞分化的调节。位于多个细胞成分中，包括 Schmidt-Lanterman 切迹；旁交界处；和周核体。在孕早期表达；眼睛;卵母细胞;耳坑;和躯干体节。与人类 SIRT2（sirtuin 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; protein deacetylation; and regulation of transcription by RNA polymerase II. Acts upstream of or within histone deacetylation; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in early conceptus; eye; oocyte; otic pit; and trunk somite. Orthologous to human SIRT2 (Sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sirt2 基因产物(3)

mRNA Protein Name
NM_022432.4 NP_071877.3 NAD-dependent protein deacetylase sirtuin-2 isoform 1
NM_001122765.1 NP_001116237.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2
NM_001122766.1 NP_001116238.1 NAD-dependent protein deacetylase sirtuin-2 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
34059674 MGI
enables histone deacetylase activity IMP
IMP: 通过突变表型推断
24334550 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17521387 MGI
enables protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
17681146 MGI
enables protein lysine deacetylase activity IMP
IMP: 通过突变表型推断
17521387 MGI
enables tubulin deacetylase activity IMP
IMP: 通过突变表型推断
24334550 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of NLRP3 inflammasome complex assembly IMP
IMP: 通过突变表型推断
23502856 MGI
involved in cellular lipid catabolic process IMP
IMP: 通过突变表型推断
19037106 MGI
involved in cellular response to caloric restriction IDA
IDA: 通过直接分析推断
17521387 MGI
involved in cellular response to epinephrine stimulus IDA
IDA: 通过直接分析推断
19037106 MGI
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
17521387 MGI
acts upstream of or within chromatin organization IGI
IGI: 通过遗传相互作用推断
20562830 MGI
involved in epigenetic regulation of gene expression IMP
IMP: 通过突变表型推断
23908241 MGI
involved in myelination in peripheral nervous system IMP
IMP: 通过突变表型推断
21949390 MGI
acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly IMP
IMP: 通过突变表型推断
23502856 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
17681146 MGI
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
21949390 MGI
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
17521387 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17681146 MGI
involved in positive regulation of DNA binding IDA
IDA: 通过直接分析推断
17521387 MGI
involved in positive regulation of attachment of spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
24334550 MGI
involved in positive regulation of cell division IMP
IMP: 通过突变表型推断
24334550 MGI
involved in positive regulation of execution phase of apoptosis IMP
IMP: 通过突变表型推断
17521387 MGI
involved in positive regulation of meiotic nuclear division IMP
IMP: 通过突变表型推断
24334550 MGI
involved in positive regulation of oocyte maturation IMP
IMP: 通过突变表型推断
24334550 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
24681946 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17521387 MGI
involved in protein deacetylation IDA
IDA: 通过直接分析推断
17681146 MGI
involved in protein deacetylation IMP
IMP: 通过突变表型推断
17521387 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
23126280 MGI
involved in regulation of myelination IMP
IMP: 通过突变表型推断
21949390 MGI
acts upstream of or within tubulin deacetylation IGI
IGI: 通过遗传相互作用推断
20562830 MGI
acts upstream of or within tubulin deacetylation IMP
IMP: 通过突变表型推断
23126280 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Schmidt-Lanterman incisure IDA
IDA: 通过直接分析推断
16933150 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
11056054 MGI
located in meiotic spindle IDA
IDA: 通过直接分析推断
24334550 MGI
located in midbody IDA
IDA: 通过直接分析推断
24334550 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
26767982 MGI
located in myelin sheath IDA
IDA: 通过直接分析推断
16933150 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19037106 MGI
located in paranodal junction IDA
IDA: 通过直接分析推断
16933150 MGI
located in perikaryon IDA
IDA: 通过直接分析推断
16933150 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16933150 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sirt2 蛋白结构

SIRT1

SIRT1: cd01408 (76 - 330)

  • 0
  • 100
  • 200
  • 300
  • 389 a.a.
蛋白主名 其他名称

NAD-dependent protein deacetylase sirtuin-2

NAD-dependent deacetylase sirtuin-2

NAD-dependent protein defatty-acylase sirtuin-2

SIR2-like protein 2

mSIR2L2

regulatory protein SIR2 homolog 2

silent mating type information regulation 2, (S.cerevisiae, homolog)-like

sirtuin 2

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0150 Nicotinamide Inhibitor 99.99% 是
HY-B0879A Suramin sodium salt Inhibitor 99.48% 是
HY-B0879 Suramin Inhibitor / 否
HY-B0150A Nicotinamide Hydrochloride Inhibitor / 否
Pre-clinical Phase
生物活性分子 (43)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10532 SRT 1720 Activator 99.90% 否
HY-107454 OSS_128167 Inhibitor 98.63% 否
HY-100578 AGK2 Inhibitor 99.62% 否
HY-15145 SRT 1720 monohydrochloride Activator 99.92% 否
HY-13515 Sirtinol Inhibitor ≥98.0% 否
HY-101278 Thiomyristoyl Inhibitor 99.74% 否
HY-100591 SirReal2 Inhibitor ≥99.0% 否
HY-16691 AK-7 Inhibitor 99.93% 否
HY-100732 Cambinol Inhibitor 99.89% 否
HY-15510 Tenovin-6 Inhibitor 98.33% 否
HY-101073 Salermide Inhibitor ≥98.0% 否
HY-136199 SIRT1-IN-1 Inhibitor 98.19% 否
HY-103636 PROTAC Sirt2 Degrader-1 Inhibitor 98.71% 否
HY-101465 AK-1 Inhibitor 99.97% 否
HY-16616 SIRT-IN-2 Inhibitor 98.08% 否
HY-N1926 Dihydrocoumarin Inhibitor 99.81% 否
HY-146689 SIRT1-IN-2 Inhibitor 98.86% 否
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% 否
HY-107660 SIRT2-IN-8 Inhibitor 99.32% 否
HY-B0150R Nicotinamide (Standard) Inhibitor 99.85% 否
HY-112427 Sirt2-IN-1 Inhibitor 98.71% 否
HY-151519 SIRT2-IN-9 Inhibitor 99.45% 否
HY-16615 SIRT-IN-1 Inhibitor 98.58% 否
HY-146690 SIRT1-IN-3 Inhibitor 99.18% 否
HY-148408 SIRT2-IN-11 Inhibitor 99.94% 否
HY-147233 MIND4-19 Inhibitor 99.94% 否
HY-111522 RK-9123016 Inhibitor 99.02% 否
HY-111329 JGB1741 Inhibitor 99.05% 否
HY-111303 CHIC35 Inhibitor / 否
HY-160617 SIRT2-IN-14 Inhibitor / 否
HY-145958 Sirt2-IN-6 Inhibitor / 否
HY-118343 AC-93253 Inhibitor / 否
HY-163532 FLS-359 Modulator / 否
HY-149637 HSP70/SIRT2-IN-1 Inhibitor / 否
HY-123653 SirReal-1 Inhibitor / 否
HY-160944 hsa62 Inhibitor / 否
HY-150727 SIRT5 inhibitor 4 Inhibitor / 否
HY-115979 Sirt2-IN-5 Inhibitor / 否
HY-W841840 SR94 Inhibitor / 否
HY-146013 Sirt1/2-IN-1 Inhibitor / 否
HY-156027 SIRT6-IN-3 Inhibitor / 否
HY-119889 A1B11 Inhibitor / 否
HY-117442 A2B57 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirt2 NCBI NCBI:22933
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