2. Gene
  3. SNAPC4 - small nuclear RNA activating complex polypeptide 4 Gene

SNAPC4 - small nuclear RNA activating complex polypeptide 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：小核 RNA 激活复合多肽 4

种属: Homo sapiens

同用名: SNAP190; PTFalpha

基因 ID: 6621 | 基因类型: protein coding

关于 SNAPC4

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,375,571-136,400,170 (from NCBI)

This gene has 7 transcripts (splice variants), 184 orthologues and 6 paralogues. Broad expression in testis (RPKM 5.9), spleen (RPKM 2.6) and 25 other tissues.

功能概要

该基因编码小核 RNA 激活蛋白 (SNAP) 复合物的最大亚基。编码的蛋白质包含一个 Myb DNA 结合结构域，对于小核 RNA 启动子的 RNA 聚合酶 II 和 III 聚合酶转录至关重要。该基因的突变与强直性脊柱炎有关。[RefSeq 提供，2016 年 7 月]

This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. [provided by RefSeq, Jul 2016]

SNAPC4 基因产物(4)

mRNA Protein Name
NM_001394201.1 NP_001381130.1 snRNA-activating protein complex subunit 4 isoform a
NM_001394202.1 NP_001381131.1 snRNA-activating protein complex subunit 4 isoform b
NM_001394203.1 NP_001381132.1 snRNA-activating protein complex subunit 4 isoform b
NM_003086.4 NP_003077.2 snRNA-activating protein complex subunit 4 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9418884 GOA
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: 通过直接分析推断
9418884 GOA
enables RNA polymerase III general transcription initiation factor activity IDA
IDA: 通过直接分析推断
9418884 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11056176 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in snRNA transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9418884 GOA
involved in snRNA transcription by RNA polymerase III IDA
IDA: 通过直接分析推断
9418884 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of snRNA-activating protein complex IDA
IDA: 通过直接分析推断
9418884 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNAPC4 蛋白结构

Myb_DNA-bind_6

Myb_DNA-bind_6: Myb-like DNA-binding domain (297 - 357)

Myb_DNA-bind_6

Myb_DNA-bind_6: Myb-like DNA-binding domain (404 - 464)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1469 a.a.
蛋白主名 其他名称

snRNA-activating protein complex subunit 4

PSE-binding factor subunit alpha

SNAPC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SNAPC4 Q5SXM2 SNAPC1 Homo sapiens Q16533
Anti Tag CoIP
36369505
种属内
SNAPC4 Q5SXM2 SNAPC1 Homo sapiens Q16533
Anti Tag CoIP
11056176
种属内
SNAPC4 Q5SXM2 SNAPC5 Homo sapiens O75971
Anti Tag CoIP
33961781
种属内
SNAPC4 Q5SXM2 SNAPC5 Homo sapiens O75971
Anti Tag CoIP
11056176
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spondylitis
Deafness, Autosomal Recessive 99

DFNB99

Autosomal Recessive Nonsyndromic Deafness 99

Autosomal Recessive Deafness 99

Deafness, Autosomal Recessive, 99
Armfield Syndrome

X-Linked Intellectual Disability, Armfield Type

Armfield X-Linked Mental Retardation Syndrome

Mental Retardation Syndrome, X-Linked, Armfield Type

Mrxsa

Syndromic X-Linked Mental Retardation Armfield Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13479 SNAPC4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SNAPC4 RGD RGD:1309048
Bos taurus SNAPC4 VGNC VGNC:58415
Mus musculus SNAPC4 MGD MGI:2443935
Felis catus SNAPC4 VGNC VGNC:65522
Macaca mulatta SNAPC4 VGNC VGNC:77667
Canis familiaris SNAPC4 VGNC VGNC:46593
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