1. Gene
  2. Brd3 - bromodomain containing 3 Gene

Brd3 - bromodomain containing 3 Gene

中文名称:含溴结构域 3

种属: Mus musculus

同用名: ORFX; Fsrg2; RINGL3; 2410084F24Rik

基因 ID: 67382 | 基因类型: protein coding

关于 Brd3

Chromosome 2: 27,335,591-27,397,674 reverse strand.GRCm39:CM000995.3

This gene has 10 transcripts (splice variants), 150 orthologues and 11 paralogues. Ubiquitous expression in CNS E11.5 (RPKM 15.9), limb E14.5 (RPKM 14.1) and 28 other tissues.

功能概要

预测该基因编码的蛋白可启动赖氨酸乙酰化组蛋白结合活性和核小体组蛋白结合活性。预计通过 RNA 聚合酶 II 参与染色质重塑和转录调控。预测作用于染色质组织的上游或内部。预计在染色质和细胞核中有活性。以多种结构表达,包括中枢神经系统;早孕;泌尿生殖系统;淋巴系统;和视网膜。与人类 BRD3 同源(含 3 的溴结构域)。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable lysine-acetylated histone binding activity and nucleosomal histone binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and retina. Orthologous to human BRD3 (bromodomain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Brd3 基因产物(3)

mRNA Protein Name
NM_001113574.1 NP_001107046.1 bromodomain-containing protein 3 isoform 1
NM_023336.4 NP_075825.3 bromodomain-containing protein 3 isoform 2
NM_001113573.1 NP_001107045.1 bromodomain-containing protein 3 isoform 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endodermal cell differentiation IMP
IMP: 通过突变表型推断
32895492 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Brd3 蛋白结构

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (32 - 138)

Bromo_Brdt_II_like

Bromo_Brdt_II_like: cd05498 (309 - 410)

BET

BET: pfam17035 (571 - 635)

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  • 726 a.a.
蛋白主名 其他名称

bromodomain-containing protein 3

bromodomain-containing FSH-like protein FSRG2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Brd3 NCBI NCBI:8019