BRD3 - bromodomain containing 3 Gene

中文名称：含溴结构域 3

种属: Homo sapiens

同用名: ORFX; RING3L

基因 ID: 8019 | 基因类型: protein coding

关于 BRD3

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:134,030,305-134,068,548 (from NCBI)

This gene has 6 transcripts (splice variants), 150 orthologues, 11 paralogues and is associated with 77 phenotypes. Ubiquitous expression in endometrium (RPKM 8.0), brain (RPKM 7.5) and 25 other tissues.

功能概要

该基因是根据其与编码 RING3 蛋白 (一种丝氨酸/苏氨酸激酶) 的基因的同源性来鉴定的。该基因定位于 9q34，该区域包含几个主要的组织相容性复合体 (MHC) 基因。所编码蛋白质的功能尚不清楚。[RefSeq 提供，2008 年 7 月]

This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

BRD3 基因产物(8)

mRNA	Protein	Name
NM_007371.4	NP_031397.1	bromodomain-containing protein 3
XM_047423904.1	XP_047279860.1	bromodomain-containing protein 3 isoform X1
XM_047423903.1	XP_047279859.1	bromodomain-containing protein 3 isoform X1
XM_047423905.1	XP_047279861.1	bromodomain-containing protein 3 isoform X2
XM_047423906.1	XP_047279862.1	bromodomain-containing protein 3 isoform X2
XM_011519052.3	XP_011517354.1	bromodomain-containing protein 3 isoform X1
XM_017015165.3	XP_016870654.1	bromodomain-containing protein 3 isoform X2
XM_006717291.4	XP_006717354.1	bromodomain-containing protein 3 isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chromatin binding	IDA IDA: 通过直接分析推断	18406326	GOA
enables lncRNA binding	IDA IDA: 通过直接分析推断	32895492	GOA
enables lysine-acetylated histone binding	IDA IDA: 通过直接分析推断	22464331	GOA
enables molecular condensate scaffold activity	IDA IDA: 通过直接分析推断	32895492	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20195357	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in endodermal cell differentiation	IDA IDA: 通过直接分析推断	32895492	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	32895492	GOA
involved in protein localization to chromatin	IDA IDA: 通过直接分析推断	29567837	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18406326	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	32895492	GOA
located in nucleus	IDA IDA: 通过直接分析推断	25593309	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRD3 蛋白结构

Bromodomain

0
200
400
600
726 a.a.

蛋白主名

其他名称

bromodomain-containing protein 3

RING3-like protein

关联疾病

疾病名称

别名

Foodborne Botulism

Botulism	Botulism Poisoning
Intoxication With Clostridium Botulinum Toxin	Wound Botulism
Food Poisoning Due To Clostridium Botulinum	Infection Due To Clostridium Botulinum
Infant Botulism	Intoxication Botulism
Botulism, Infantile	Clostridium Botulinum Poisoning
Botulism Nos

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Infant Botulism

Infant Intestinal Botulism	Infant Intestinal Toxemia Botulism
Infant Intestinal Toxin-Mediated Botulism	Infantile Botulism
Botulism, Infantile

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Wound Botulism

Cutaneous Infectious Botulism	Cutaneous Toxin-Mediated Botulism
Inoculation Botulism	Skin Infectious Botulism
Skin Toxin-Mediated Botulism

Bladder Sarcoma

Sarcoma Of Bladder

Sarcoma Of The Urinary Bladder

Intestinal Botulism

Intestinal Colonization Botulism	Intestinal Toxemia Botulism
Intestinal Toxin-Mediated Botulism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-112090	ABBV-744	Inhibitor	99.97%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100972	ARV-771	Inhibitor	99.87%	否
HY-136570	GSK778	Inhibitor	98.93%	否
HY-136571	GSK046	Inhibitor	99.65%	否
HY-101519	BETd-260	Inhibitor	99.59%	否
HY-141438	SIM1	Inhibitor	99.57%	否
HY-112429	HJB97	Inhibitor	98.05%	否
HY-138563	GSK973	Inhibitor	99.97%	否
HY-120000	MS402	Inhibitor	99.62%	否
HY-130622	LT052	Inhibitor	98.77%	否
HY-114504	RVX-297	Inhibitor	95.00%	否
HY-112610	CF53	Inhibitor	99.78%	否
HY-114416	GS-626510	Inhibitor	99.80%	否
HY-131061	BET bromodomain inhibitor 1	Inhibitor	99.91%	否
HY-145264	OARV-771	Inhibitor	98.33%	否
HY-110215	XD14	Inhibitor	95.02%	否
HY-126325	BY27	Inhibitor	/	否
HY-168635	SJ46420	Inhibitor	/	否
HY-143471	WNY0824	Inhibitor	/	否
HY-169170	PARP1/BRD4-IN-3	Inhibitor	/	否
HY-168634	SJ46421	Inhibitor	/	否
HY-155680	BET BD2-IN-1	Inhibitor	/	否
HY-152213	BET-IN-13	Inhibitor	/	否
HY-136570A	GSK778 hydrochloride	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	BRD3	VGNC	VGNC:60167
Mus musculus	BRD3	MGD	MGI:1914632
Bos taurus	BRD3	VGNC	VGNC:26558
Macaca mulatta	BRD3	VGNC	VGNC:70281
Canis familiaris	BRD3	VGNC	VGNC:103661
Rattus norvegicus	BRD3	RGD	RGD:1308925
Others	BRD3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BRD3 - bromodomain containing 3 Gene

关于 BRD3

功能概要

BRD3 基因产物(8)

BRD3 蛋白结构

关联疾病

直系同源

热门区域

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BRD3 - bromodomain containing 3 Gene

关于 BRD3

功能概要

BRD3 基因产物(8)

BRD3 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z