2. Gene
  3. TPD52L1 - TPD52 like 1 Gene

TPD52L1 - TPD52 like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TPD52 样 1

种属: Homo sapiens

同用名: D53; TPD53

基因 ID: 7164 | 基因类型: protein coding

关于 TPD52L1

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:125,153,773-125,264,407 (from NCBI)

This gene has 17 transcripts (splice variants), 202 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 40.8), salivary gland (RPKM 18.6) and 14 other tissues.

功能概要

该基因编码包含卷曲螺旋结构域并可能形成异聚体或同聚体的蛋白质家族成员。编码的蛋白质参与细胞增殖和钙信号传导。它还与丝裂原活化蛋白激酶激酶激酶 5 (MAP3K5/ASK1) 相互作用并正向调节 MAP3K5 诱导的细胞凋亡。已观察到多个选择性剪接的转录物变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced Apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]

TPD52L1 基因产物(8)

mRNA Protein Name
NM_001003395.3 NP_001003395.1 tumor protein D53 isoform 2
NM_001003396.3 NP_001003396.1 tumor protein D53 isoform 3
NM_001003397.3 NP_001003397.1 tumor protein D53 isoform 4
NM_001292026.3 NP_001278955.1 tumor protein D53 isoform 5
NM_001300994.3 NP_001287923.1 tumor protein D53 isoform 6
NM_001318903.2 NP_001305832.1 tumor protein D53 isoform 7
NM_001318907.2 NP_001305836.1 tumor protein D53 isoform 5
NM_003287.4 NP_003278.1 tumor protein D53 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9484778 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9484778 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9484778 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G2/M transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
16112108 GOA
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
14761963 GOA
involved in positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
14761963 GOA
involved in positive regulation of apoptotic signaling pathway IDA
IDA: 通过直接分析推断
14761963 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12963375 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
12963375 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPD52L1 蛋白结构

TPD52

TPD52: Tumour protein D52 family (7 - 188)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

tumor protein D53

tumor protein D52 like 1

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14929 TPD52L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TPD52L1 MGD MGI:1298386
Macaca mulatta TPD52L1 VGNC VGNC:78632
Felis catus TPD52L1 VGNC VGNC:66471
Canis familiaris TPD52L1 VGNC VGNC:47734
Rattus norvegicus TPD52L1 RGD RGD:1594796
Bos taurus TPD52L1 VGNC VGNC:36245
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