2. Gene
  3. Hdac9 - histone deacetylase 9 Gene

Hdac9 - histone deacetylase 9 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 9

种属: Mus musculus

同用名: HD9; HD7B; HDRP; Mitr; Hdac7b; mKIAA0744; D030072B18Rik

基因 ID: 79221 | 基因类型: protein coding

关于 Hdac9

Chromosome 12: 34,097,579-34,967,094 reverse strand.GRCm39:CM001005.3

This gene has 12 transcripts (splice variants), 235 orthologues, 10 paralogues and is associated with 2 phenotypes. Broad expression in frontal lobe adult (RPKM 2.7), cortex adult (RPKM 1.4) and 21 other tissues.

功能概要

该基因编码的蛋白可启动 DNA 结合转录因子结合活性和转录辅阻遏物活性。在几个过程的上游或内部起作用，包括确定成人寿命； RNA 聚合酶 II 对转录的负调控；和调节骨骼肌纤维的发育。组蛋白甲基转移酶复合物的一部分。以多种结构表达，包括 2 细胞期胚胎；未来的中脑；心;神经系统;和躯干肌节。与人类 HDAC9（组蛋白脱乙酰酶 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Acts upstream of or within several processes, including determination of adult lifespan; negative regulation of transcription by RNA polymerase II; and regulation of skeletal muscle fiber development. Part of Histone Methyltransferase complex. Is expressed in several structures, including 2-cell stage embryo; future midbrain; heart; nervous system; and trunk myotome. Orthologous to human HDAC9 (histone deacetylase 9). [provided by Alliance of Genome Resources, Apr 2022]

Hdac9 基因产物(2)

mRNA Protein Name
NM_001271386.1 NP_001258315.1 histone deacetylase 9 isoform 1
NM_024124.3 NP_077038.2 histone deacetylase 9 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
12242305 MGI
enables histone H3K14 deacetylase activity IMP
IMP: 通过突变表型推断
21708950 MGI
enables histone H3K9 deacetylase activity IMP
IMP: 通过突变表型推断
21708950 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11390982 MGI
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
11022042 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA repair IGI
IGI: 通过遗传相互作用推断
21746928 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: 通过遗传相互作用推断
21746928 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
15367668 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11022042 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: 通过突变表型推断
21708950 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11390982 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16280321 MGI
acts upstream of or within regulation of skeletal muscle fiber development IGI
IGI: 通过遗传相互作用推断
17786239 MGI
acts upstream of or within regulation of skeletal muscle fiber differentiation IGI
IGI: 通过遗传相互作用推断
17786239 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of histone methyltransferase complex IDA
IDA: 通过直接分析推断
12242305 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hdac9 蛋白结构

ClassIIa_HDAC9_Gln-rich-N

ClassIIa_HDAC9_Gln-rich-N: cd10163 (58 - 147)

HDAC_classIIa

HDAC_classIIa: cd11681 (652 - 1029)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1088 a.a.
蛋白主名 其他名称

histone deacetylase 9

MEF2-interacting transcription repressor MITR

histone deacetylase 7B

histone deacetylase-related protein

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13322 Pracinostat Inhibitor 99.82% 是
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18361 TMP195 Inhibitor 99.57% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18360 TMP269 Inhibitor 98.05% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-112719 BRD 4354 Inhibitor 99.66% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-149285 NT160 Inhibitor 99.58% 否
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-169259 HDAC9-IN-1 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hdac9 NCBI NCBI:9734
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z