Hdac6 - histone deacetylase 6 Gene

中文名称：组蛋白脱乙酰酶 6

种属: Mus musculus

同用名: Hd6; Sfc6; Hdac5; mHDA2

关于 Hdac6

功能概要

该基因编码的蛋白可启动细胞骨架蛋白结合活性；蛋白质脱乙酰酶活性；和泛素结合活性。参与多个过程，包括肽基丝氨酸磷酸化的正调节；蛋白质去乙酰化；和蛋白质不稳定。作用于多个过程的上游或内部，包括侵略性装配；细胞蛋白质代谢过程；和神经元投射形态发生。位于多个细胞成分中，包括树突；微管细胞骨架；和周核体。部分含蛋白质复合物。以多种结构表达，包括中枢神经系统；早期胚胎；未来的中脑；肠腺;和肺。该基因的人类直系同源物与软骨发育不良有关，伴有扁平椎、独特的短指畸形、脑积水和小眼畸形。与人类 HDAC6（组蛋白脱乙酰酶 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cytoskeletal protein binding activity; protein deacetylase activity; and ubiquitin binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein deacetylation; and protein destabilization. Acts upstream of or within several processes, including aggresome assembly; cellular protein metabolic process; and neuron projection morphogenesis. Located in several cellular components, including dendrite; microtubule cytoskeleton; and perikaryon. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early embryo; future midbrain; gut gland; and lung. Human ortholog(s) of this gene implicated in chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia. Orthologous to human HDAC6 (histone deacetylase 6). [provided by Alliance of Genome Resources, Apr 2022]