RAB29 - RAB29, member RAS oncogene family Gene

中文名称：RAB29，RAS 致癌基因家族成员

种属: Homo sapiens

同用名: RAB7L; RAB7L1

基因 ID: 8934 | 基因类型: protein coding

关于 RAB29

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,767,986-205,775,482 (from NCBI)

This gene has 9 transcripts (splice variants), 170 orthologues and 68 paralogues. Broad expression in kidney (RPKM 27.5), thyroid (RPKM 17.1) and 24 other tissues.

功能概要

启用多种功能，包括动力蛋白复合物结合活动；胍基核糖核苷酸结合活性；和驱动蛋白结合活性。参与多个过程，包括 T 细胞受体信号通路的正调控；受体回收的正向调节；和毒素运输。位于多种细胞成分中，包括高尔基体；核内体；和液泡。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including dynein complex binding activity; guanyl ribonucleotide binding activity; and Kinesin binding activity. Involved in several processes, including positive regulation of T cell receptor signaling pathway; positive regulation of receptor recycling; and toxin transport. Located in several cellular components, including Golgi apparatus; endosome; and vacuole. [provided by Alliance of Genome Resources, Apr 2022]

RAB29 基因产物(4)

mRNA	Protein	Name
NM_001135662.2	NP_001129134.1	ras-related protein Rab-7L1 isoform 1
NM_001135663.2	NP_001129135.1	ras-related protein Rab-7L1 isoform 2
NM_001135664.2	NP_001129136.1	ras-related protein Rab-7L1 isoform 3
NM_003929.3	NP_003920.1	ras-related protein Rab-7L1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GDP binding	IDA IDA: 通过直接分析推断	24510904	GOA
enables GTP binding	IDA IDA: 通过直接分析推断	24510904	GOA
enables dynein complex binding	IDA IDA: 通过直接分析推断	26021297	GOA
enables kinesin binding	IPI IPI: 通过物理相互作用推断	26021297	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	24510904	GOA
enables small GTPase binding	IDA IDA: 通过直接分析推断	26021297	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi organization	IMP IMP: 通过突变表型推断	24510904	GOA
involved in T cell activation	IMP IMP: 通过突变表型推断	26021297	GOA
involved in cellular detoxification	IMP IMP: 通过突变表型推断	22042847	GOA
NOT involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: 通过突变表型推断	24788816	GOA
involved in mitochondrion organization	IMP IMP: 通过突变表型推断	25767741	GOA
involved in modulation by host of viral process	IMP IMP: 通过突变表型推断	19376974	GOA
involved in negative regulation of neuron projection development	IDA IDA: 通过直接分析推断	24510904	GOA
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	26021297	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: 通过突变表型推断	24788816	GOA
involved in positive regulation of receptor recycling	IMP IMP: 通过突变表型推断	26021297	GOA
involved in protein localization to membrane	IMP IMP: 通过突变表型推断	25767741	GOA
involved in response to bacterium	IDA IDA: 通过直接分析推断	22042847	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: 通过突变表型推断	24788816	GOA
involved in synapse assembly	IMP IMP: 通过突变表型推断	26021297	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	22042847	GOA
located in cis-Golgi network	IDA IDA: 通过直接分析推断	26021297	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24788816	GOA
located in early endosome	IDA IDA: 通过直接分析推断	26021297	GOA
located in intracellular vesicle	IDA IDA: 通过直接分析推断	26021297	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	25767741	GOA
located in recycling endosome	IDA IDA: 通过直接分析推断	26021297	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	24510904	GOA
located in vacuole	IDA IDA: 通过直接分析推断	22042847	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB29 蛋白结构

Ras

0
100
203 a.a.

蛋白主名

其他名称

ras-related protein Rab-7L1

RAB7, member RAS oncogene family-like 1

RAB29 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RAB29	O14966	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
种属内	RAB29	O14966	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
种属内	RAB29	O14966	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
种属内	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	Pull Down	31552791
种属内	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	Confocal	24510904
种属内	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	24510904
种属内	RAB29	O14966	LRRK2	Homo sapiens	Q5S007	FPS	31552791
种属内	RAB29	O14966	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
种属内	RAB29	O14966	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
种属内	RAB29	O14966	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
种属内	RAB29	O14966	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
种属内	RAB29	O14966	LDOC1	Homo sapiens	O95751	Validated Y2H	32296183
种属内	RAB29	O14966	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
种属内	RAB29	O14966	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
种属内	RAB29	O14966	TRIM32	Homo sapiens	Q13049	Y2H Prey Pooling	32296183
种属内	RAB29	O14966	TRIM32	Homo sapiens	Q13049	Validated Y2H	32296183
种属内	RAB29	O14966	TRIM32	Homo sapiens	Q13049	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Parkinson Disease 21

PARK21	Parkinson'S Disease 21
Parkinson Disease, Type 21

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Kufor-Rakeb Syndrome

Park9	Krppd
KRS	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia
Autosomal Recessive Parkinson Disease 9	Parkinson Disease 9
Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset	Autosomal Recessive Juvenile Onset Parkinson Disease 9
Parkinson Disease Type 9	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia
Park 9	Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis
Cln12 Disease	Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis
Parkinson Disease Autosomal Recessive 9

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11540	RAB29 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RAB29	RGD	RGD:620892
Mus musculus	RAB29	MGD	MGI:2385107
Macaca mulatta	RAB29	VGNC	VGNC:81528
Canis familiaris	RAB29	VGNC	VGNC:45270
Bos taurus	RAB29	VGNC	VGNC:33636
Felis catus	RAB29	VGNC	VGNC:97586
Others	RAB29	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RAB29 - RAB29, member RAS oncogene family Gene

关于 RAB29

功能概要

RAB29 基因产物(4)

RAB29 蛋白结构

RAB29 蛋白互作信息

关联疾病

直系同源

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RAB29 - RAB29, member RAS oncogene family Gene

关于 RAB29

功能概要

RAB29 基因产物(4)

RAB29 蛋白结构

RAB29 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z