ZBED1 - zinc finger BED-type containing 1 Gene

中文名称：含锌指 BED 型 1

种属: Homo sapiens

同用名: ALTE; DREF; TRAMP; hDREF

关于 ZBED1

功能概要

该基因位于 X 和 Y 染色体的假常染色体区域 1 (PAR1) 。它早先被鉴定为与 Ac 转座因子具有相似性的基因，但被发现不具有转座酶活性。后来的研究表明，该基因产物位于细胞核中，并作为转录因子发挥作用。它与在几个与细胞增殖相关的基因启动子区域发现的 DNA 元件结合，例如组蛋白 H1，因此可能在调节与细胞增殖相关的基因中发挥作用。已发现该基因具有不同 5' 非翻译区的可变剪接转录物变体。[RefSeq 提供，2010 年 1 月]

This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]