CD47 - CD47 molecule Gene

中文名称：CD47 分子

种属: Homo sapiens

同用名: IAP; OA3; MER6

基因 ID: 961 | 基因类型: protein coding

关于 CD47

Cytogenetic location: 3q13.12 Genomic coordinates (GRCh38): 3:108,043,091-108,091,031 (from NCBI)

This gene has 6 transcripts (splice variants) and 125 orthologues. Ubiquitous expression in lung (RPKM 24.2), brain (RPKM 20.9) and 24 other tissues.

功能概要

该基因编码一种膜蛋白，它参与细胞粘附到细胞外基质时细胞内钙浓度的增加。编码的蛋白也是血小板反应蛋白 C 端细胞结合域的受体，可能在膜转运和信号转导中发挥作用。该基因具有广泛的组织分布，并且在 Rh 红细胞上的表达减少。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

CD47 基因产物(3)

mRNA	Protein	Name
NM_001382306.1	NP_001369235.1	leukocyte surface antigen CD47 isoform 3 precursor
NM_001777.4	NP_001768.1	leukocyte surface antigen CD47 isoform 1 precursor
NM_198793.3	NP_942088.1	leukocyte surface antigen CD47 isoform 2 precursor

CD47 蛋白结构

V-set_CD47

CD47

0
100
200
300
323 a.a.

蛋白主名

其他名称

leukocyte surface antigen CD47

CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

重组 CD47 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7335	CD47 Protein, Human (HEK293, Fc)	Q08722-1 (Q19-P139)	≥95%
HY-P7336	CD47 Protein, Human (HEK293, His)	Q08722-1/NP_942088.1 (Q19-P139)	≥95%
HY-P72359	CD47 Protein, Human (Biotinylated, HEK293, Avi-His)	Q08722-1 (Q19-P139)	≥95%
HY-P72917	CD47 Protein, Human (HEK293)	Q08722-1/NP_942088.1 (Q19-P139)	≥95%
HY-P78094	CD47 Protein, Human (Biotinylated, HEK293, Fc)	Q08722-1 (Q19-P139)	≥95%
HY-P78095	CD47 Protein, Human (Biotinylated, HEK293, His-Avi)	Q08722-1 (Q19-P139)	≥95%
HY-P78561	CD47 Protein, Human (Biotinylated, HEK293, mFc-Avi)	Q08722-1 (Q19-P139)	≥95%
HY-P78908	CD47 Protein, Human (Biotinylated, HEK293, hFc-Avi)	Q08722-1 (Q19-P139)	≥95%

关联疾病

疾病名称

别名

Hereditary Spherocytosis

Congenital Spherocytic Hemolytic Anemia	Spherocytic Anemia
Congenital Spherocytosis	Spherocytosis, Type 1
Minkowski Chauffard Syndrome	Hs
Minkowski-Chauffard Disease	Minkowski-Chauffard Syndrome
Spherocytosis Hereditary	Spherocytosis, Hereditary
Anemia, Hereditary Spherocytic Hemolytic

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia	Thrombasthenia Of Glanzmann And Naegeli
Glanzmann'S Thrombasthenia	Bdplt2
Platelet Glycoprotein Iib-Iiia Deficiency	Deficiency Of Platelet Fibrinogen Receptor
GT1	Gt
Platelet Fibrinogen Receptor Deficiency	Glycoprotein Complex Iib-Iiia Deficiency
Deficiency Of Glycoprotein Complex Iib-Iiia	Glycoprotein Iib/Iiia Defect
Glanzmann Thrombasthenia, Type A	Thrombasthenia
Bleeding Disorder, Platelet-Type, 2	Gp Iib-Iiia Complex Deficiency
Deficiency Of Gp Iib-Iiia Complex	Platelet-Type Bleeding Disorder 2
Thrombocytasthenia	Deficiency Of Gp 2b 3a Complex
Diacyclothrombopathia 2b 3a	Glanzmann Thrombasthenia Type A
Platelet Fibrinogen Receptor, Deficiency Of	Platelet Glycoprotein 2b 3a Deficiency
Glanzmann Disease	Glanzmann-Naegeli Disorder
Hereditary Hemorrhagic Thrombasthenia	Hereditary Thrombasthenia
Bleeding Disorder Platelet-Type 2

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Congenital Dyserythropoietic Anemia

Congenital Dyshaematopoietic Anaemia	Dyserythropoietic Anemia, Congenital
Cda	Anemia, Dyserythropoietic, Congenital
Anemia Dyserythropoietic Congenital	Cda - [Congenital Dyserythropoietic Anaemia]
Dyserythropoietic Dyshaematopoietic Congenital Anaemia	Dyshaematopoietic Anaemia
Dyserythropoietic Anaemia

Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome	Rh Disease
HDFNRH	Rh Fetomaternal Incompatibility
Rh-Null Syndrome

Contagious Pustular Dermatitis

Ecthyma, Contagious	Orf
Ecthyma Contagiosum	Scabby Mouth
Sheep Pox	Thistle Disease
Contagious Pustular Dermatosis

Tenosynovial Giant Cell Tumor

Fibrous Histiocytoma Of Tendon Sheath	Giant Cell Tumor Of Tendon Sheath
Giant Cell Tumor Of Tenosynovium	Giant Cell Tumour Of Tendon Sheath
Giant Cell Tumour Of Tenosynovium	Tenosynovial Giant Cell Tumour
Diffuse-Type Gct	Diffuse-Type Giant Cell Tumor
Pigmented Villonodular Synovitis	Tgct
Tsgct

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Refractory Plasma Cell Neoplasm

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-16438	RRx-001	Inhibitor	99.16%	Phase 3

目录号	产品名	作用方式	纯度	Phase
HY-P99029	Magrolimab	Inhibitor	99.92%	Phase 3
HY-P99026	Lemzoparlimab	Inhibitor	/	Phase 2
HY-P99777	Ontorpacept	Inhibitor	99.57%	Phase 2
HY-P99172	CC-90002	Inhibitor	97.97%	Phase 1
HY-P990033	Anzurstobart	Inhibitor	98.53%	Phase 1
HY-P99533	Urabrelimab	Inhibitor	98.49%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-143224B	NCGC00138783 TFA	Inhibitor	99.71%	否
HY-P0144	Thrombospondin-1 (1016-1023) (human, bovine, mouse)	Inhibitor	99.08%	否
HY-115983	DMUP	Inhibitor	≥98.0%	否
HY-143224	NCGC00138783	Inhibitor	/	否
HY-151132	Glutaminyl cyclases-IN-1	Inhibitor	98.21%	否
HY-RS02250	CD47 Human Pre-designed siRNA Set A	Inhibitor	/	否
HY-P10420	RS17	Inhibitor	/	否
HY-143224A	NCGC00138783 free base	Inhibitor	/	否
HY-P10388	TAX2 peptide	Inhibitor	/	否
HY-P3968	Thrombospondin-1 (1016-1021) (human, bovine, mouse)		/	否
HY-143225	NCGC00538431	Inhibitor	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P99175	KWAR 23	Inhibitor	99.80%	否
HY-P99706	Ligufalimab	Inhibitor	98.81%	否
HY-P990132	Anti-Mouse/Rat/Human CD47/IAP Antibody (MIAP410)	Inhibitor	95.00%	否
HY-P990131	Anti-Mouse CD47/IAP Antibody (MIAP301)	Inhibitor	95.00%	否
HY-P990694	Zeripatamig	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CD47	VGNC	VGNC:60628
Bos taurus	CD47	VGNC	VGNC:27035
Mus musculus	CD47	MGD	MGI:96617
Macaca mulatta	CD47	VGNC	VGNC:70767
Rattus norvegicus	CD47	RGD	RGD:2308
Canis familiaris	CD47	VGNC	VGNC:38960
Macaca fascicularis	CD47	NCBI	NCBI:102139846
Others	CD47	NCBI

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