2. Immunology/Inflammation
  3. CD47
  4. KWAR 23

KWAR 23 

目录号: HY-P99175 纯度: 99.80%
COA

摩尔计算器

KWAR23 是一种 anti-human SIRPα 抗体。KWAR23 以高亲和力结合 human SIRPα，并破坏其与 CD47 的结合。KWAR23 与 tumor-opsonizing 抗体联合使用具有抗肿瘤活性，可用于研究癌症免疫疗法。

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CAS No. : 2243227-60-1

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1 mg ￥6200
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KWAR 23 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research[1].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Human
体外研究
(In Vitro)

KWAR 23 (0-1 μM; 4 h) shows antitumor activity of human neutrophil and macrophage[1].
KWAR 23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KWAR 23 相关抗体:

Cell Viability Assay[1]

Cell Line: Human macrophages and lymphoma cells
Concentration: 0-1 μM
Incubation Time: 4 h
Result: Showed human macrophages and neutrophils killing tumor cells following treatment with KWAR23.
体内研究
(In Vivo)

KWAR23 (intraperitoneal injection; 10 mg/kg; every other day; 21 d) exhibits effective antitumor activity in a human SIRPA knockin mouse model[1].
KWAR23 enhances neutrophil and macrophage antitumor activity in SRG Mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SIRPA knock-in mouse model injected with Burkitt’s lymphoma cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg; every other day; 21 d
Result: Led to strong inhibition of tumor growth when combined with Rituximab.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized SIRP alpha/CD172a Protein, Human can bind KWAR 23. The EC50 for this effect is 5.3 ng/mL.
纯度 & 产品资料
参考文献

KWAR 23 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KWAR 232243227-60-1KWAR23KWAR-23CD47Cluster of Differentiation 47MER6OA3antitumor activitycancer immunotherapyhuman macrophageslymphoma cellInhibitorinhibitorinhibit

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