2. Gene
  3. G3BP2 - G3BP stress granule assembly factor 2 Gene

G3BP2 - G3BP stress granule assembly factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G3BP 应力颗粒装配因子 2

种属: Homo sapiens

基因 ID: 9908 | 基因类型: protein coding

关于 G3BP2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,642,786-75,724,437 (from NCBI)

This gene has 90 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 45.6), thyroid (RPKM 35.2) and 25 other tissues.

功能概要

启用 RNA 结合活性。参与应激颗粒组装和蛋白质同源寡聚化的正向调节。位于细胞质应激颗粒和细胞质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Involved in positive regulation of stress granule assembly and protein homooligomerization. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

G3BP2 基因产物(21)

mRNA Protein Name
NM_001400004.1 NP_001386933.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400005.1 NP_001386934.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400006.1 NP_001386935.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400007.1 NP_001386936.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400008.1 NP_001386937.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400010.1 NP_001386939.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400011.1 NP_001386940.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400012.1 NP_001386941.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400013.1 NP_001386942.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400014.1 NP_001386943.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400015.1 NP_001386944.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400016.1 NP_001386945.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400017.1 NP_001386946.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400018.1 NP_001386947.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400019.1 NP_001386948.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400020.1 NP_001386949.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400021.1 NP_001386950.1 ras GTPase-activating protein-binding protein 2 isoform c
NM_001400022.1 NP_001386951.1 ras GTPase-activating protein-binding protein 2 isoform d
NM_012297.5 NP_036429.2 ras GTPase-activating protein-binding protein 2 isoform a
NM_203504.3 NP_987100.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_203505.3 NP_987101.1 ras GTPase-activating protein-binding protein 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular condensate scaffold activity IDA
IDA: 通过直接分析推断
32302570 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19615732 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of stress granule assembly IMP
IMP: 通过突变表型推断
23279204 GOA
involved in protein homooligomerization IMP
IMP: 通过突变表型推断
23279204 GOA
involved in stress granule assembly IDA
IDA: 通过直接分析推断
27022092 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic stress granule IMP
IMP: 通过突变表型推断
23279204 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

G3BP2 蛋白结构

NTF2

NTF2: Nuclear transport factor 2 (NTF2) domain (11 - 133)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (333 - 390)

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  • 482 a.a.
蛋白主名 其他名称

ras GTPase-activating protein-binding protein 2

G3BP-2

G3BP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Anti Bait CoIP
34901782
种属内
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
FPS
34799561
种属内
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Anti Tag CoIP
19615732
种属内
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Anti Tag CoIP
35271311
种属内
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Y2H Array
31515488
种属内
G3BP2 Q9UN86 USP10 Homo sapiens Q14694
Y2H Prey Pooling
25416956
种属间
G3BP2 Q9UN86 N SARS-CoV-2 P0DTC9
FPS
34799561
种属间
G3BP2 Q9UN86 N SARS-CoV-2 P0DTC9
Pull Down
34400613
种属间
G3BP2 Q9UN86 Twist1 Mus musculus P26687
Anti Tag CoIP
25893917
种属间
G3BP2 Q9UN86 Twist1 Mus musculus P26687
Anti Bait CoIP
25893917
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mouth Disease

Mouth Diseases

Mouth Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131649 Compound C108 98.66% 否
HY-160706 HHQ16 / 否
HY-RS05190 G3BP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta G3BP2 VGNC VGNC:100229
Bos taurus G3BP2 VGNC VGNC:29177
Mus musculus G3BP2 MGD MGI:2442040
Felis catus G3BP2 VGNC VGNC:78500
Rattus norvegicus G3BP2 RGD RGD:1309571
Canis familiaris G3BP2 VGNC VGNC:41039
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