2. Cell Cycle/DNA Damage Epigenetics Autophagy Anti-infection
  3. Aurora Kinase Autophagy Influenza Virus Parasite
  4. Hesperadin hydrochloride

Hesperadin hydrochloride 是 Aurora A 和 B 的 ATP 竞争性吲哚酮抑制剂。Hesperadin hydrochloride 以 250 nM 的 IC50 抑制 Aurora B。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Hesperadin hydrochloride Chemical Structure

Hesperadin hydrochloride Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Hesperadin hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Hesperadin hydrochloride:

Hesperadin hydrochloride 相关抗体

Top Publications Citing Use of Products

    Hesperadin hydrochloride purchased from MCE. Usage Cited in: Behav Neurol. 2020 Feb 3;2020:2476861.  [Abstract]

    Administration of hesperadin influences endogenous expression of MST4, pAKT, AKT, and LC3 12 h following ICH. Representative western blot bands for MST4, pAKT, AKT, and LC3 expression in sham and ICH mice 12 h following ICH.

    查看 Aurora Kinase 亚型特异性产品:

    查看所有亚型
    Aurora Kinase Aurora A Aurora B Aurora C

    查看 Parasite 亚型特异性产品:

    查看所有亚型
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Hesperadin hydrochloride is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin hydrochloride inhibits Aurora B with an IC50 of 250 nM[1].

    IC50 & Target[1]

    Aurora B

    250 nM (IC50)

    体外研究
    (In Vitro)

    Hesperadin (10-100 nM) inhibits the Aurora kinase-1 (TbAUK1)-mediated phosphoryation of trypanosome histone H3 (TbH3) in a dose dependent manner, with an IC50 of 40 nM[1].
    Hesperadin (0.01-10 μM; 24 or 48 hours) inhibits growth of bloodstream forms (BF) and procyclic forms (PF) cultures[1].
    Hesperadin (100-200 nM; 24-72 hours) alters cell morphology and inhibits cell cycle progression similar to the RNAi knockdown of TbAUK1[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Hesperadin hydrochloride 相关抗体:

    Cell Viability Assay[1]

    Cell Line: M110 cells
    Concentration: 0.01, 0.1, 1, 10 μM
    Incubation Time: 24 hours or 48 hours
    Result: Inhibiting growth of BF cultures with an IC50 of 50 nM, while the inhibition of PF growth required approximately 11-fold more Hesperadin, with an IC50 of 550 nM.

    Cell Cycle Analysis[1]

    Cell Line: M110 cells
    Concentration: 100, 200 nM
    Incubation Time: 24, 48, 72 hours
    Result: Had a strong effect on cell growth and mitotic progression at 100-200 nM.
    体内研究
    (In Vivo)

    Hesperadin (20 mg/kg/d; i.v.) prolongs the survival of xenograft mice via synergistic effect with Temozolomide (TMZ)[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-week-old female nude mice injected GBM cells[2]
    Dosage: 20 mg/kg/d
    Administration: I.v. injection
    Result: Increased the survival of xenograft mice models.
    分子量

    553.12

    Formula

    C29H33ClN4O3S
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Hesperadin hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    HesperadinAurora KinaseAutophagyInfluenza VirusParasiteAuroraABbloodstreamprocyclicformsBFPFInhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    Hesperadin hydrochloride
    目录号：
    HY-12054A
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z