2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Endogenous Metabolite Parasite Apoptosis
  4. Linolelaidic acid

Linolelaidic acid  (Synonyms: 亚麻酸; Linoelaidic acid)

目录号: HY-W071746 纯度: 99.52%
COA 产品使用指南

摩尔计算器

Linolelaidic acid (Linoelaidic acid) 属于 omega-6 反式脂肪酸 (TFA)，是一种具有口服活性的人体必需营养素，可添加于肠内营养制剂 (口服)、肠外营养制剂 (静脉注射) 以及婴儿配方食品中。Linolelaidic acid 具有抗炎和抗寄生虫 (Parasite) 活性，并且可以诱导细胞凋亡 (Apoptosis)。Linolelaidic acid 可用于感染领域研究。

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Linolelaidic acid Chemical Structure

Linolelaidic acid Chemical Structure

CAS No. : 506-21-8

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Customer Review

Linolelaidic acid 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Linolelaidic acid (Linoelaidic acid) is an omega-6 trans fatty acid (TFA) that is an essential nutrient with oral activity. Linolelaidic acid can be added to enteral nutrition (oral), parenteral nutrition (intravenous), and infant formula. Linolelaidic acid has anti-inflammatory and anti-parasitic ((Parasite)) activities, and can induce Apoptosis. Linolelaidic acid is useful for research in infections[1][2][3].

体外研究
(In Vitro)

Linolenic Acid 对 P. falciparum D10 株(氯喹敏感株) 和 Dd2 株 (氯喹耐药株) 具有抑制活性，IC50 分别为 4.12 μg/mL 和 5.04 μg/mL[2]。
Linolelaidic acid (50 μM, 24 小时) 通过脂筏诱导人脐静脉内皮细胞的凋亡、细胞周期停滞和炎症[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Linolelaidic acid 相关抗体:

Cell Viability Assay[3]

Cell Line: Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration: 50 μM
Incubation Time: 24 h
Result: Resulted in a significant decrease in cell viability.

Apoptosis Analysis[3]

Cell Line: Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration: 50 μM
Incubation Time: 24 h
Result: Resulted in a significant increase in the number of apoptotic cells and the cell population in the G1 phase.

Western Blot Analysis[3]

Cell Line: Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration: 50 μM
Incubation Time: 24 h
Result: Led to a significant increase in the expression levels of pro-apoptotic proteins (caspase-3, -8, Bax, p53) and inflammatory factors (vascular cell adhesion molecule-1, intercellular adhesion molecule, E-selectin, and nitric oxide), while the expression level of the anti-apoptotic protein Bcl-2 was significantly decreased.
体内研究
(In Vivo)

Linolenic Acid (10 mg/kg，口服，每日一次，连续 4 天) 在 P. berghei (ANKA) 株诱导的疟疾 C57BL/6 小鼠模型中表现出抗寄生虫活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. berghei (ANKA) strain-induced malaria C57BL/6 mice model (7-to-10-week old)[3]
Dosage: 10 mg/kg
Administration: Oral gavage (p.o.), once daily for 4 days
Result: Inhibited the growth of P. berghei by 70%.
Animal Model: High-fat diet-fed streptozotocin (HFD-STZ) rat model[2]
Dosage: 500 μg/kg
Administration: Oral gavage (p.o.), once daily for 4 weeks, 30 min myocardial ischemia followed by 4 or 6 h reperfusion after 4 weeks
Result: Significantly improved the instantaneous first derivation of left ventricle pressure, reduced infarct size, plasma creatine kinase and lactate dehydrogenase activities, and apotosis at the end of reperfusion in HFD-STZ diabetic rats.
Not only significantly reduced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) concentrations but reduced the increase in superoxide production and malonaldialdehyde formation and simultaneously enhanced the antioxidant capacity in the diabetic hearts.
Increased myocardial PI3K expression and Akt phosphorylation in diabetic but not normal rats.
分子量

280.45

Formula

C18H32O2
CAS 号
性状

液体（密度：0.89 g/cm3）

颜色

Colorless to light yellow

中文名称

亚麻酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (445.71 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5657 mL 17.8285 mL 35.6570 mL
5 mM 0.7131 mL 3.5657 mL 7.1314 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.52%

COA (277 KB) HNMR (268 KB) RP-HPLC (207 KB) MS (70 KB)

产品使用指南 (1538 KB)
参考文献

Linolelaidic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5657 mL 17.8285 mL 35.6570 mL 89.1424 mL
5 mM 0.7131 mL 3.5657 mL 7.1314 mL 17.8285 mL
10 mM 0.3566 mL 1.7828 mL 3.5657 mL 8.9142 mL
15 mM 0.2377 mL 1.1886 mL 2.3771 mL 5.9428 mL
20 mM 0.1783 mL 0.8914 mL 1.7828 mL 4.4571 mL
25 mM 0.1426 mL 0.7131 mL 1.4263 mL 3.5657 mL
30 mM 0.1189 mL 0.5943 mL 1.1886 mL 2.9714 mL
40 mM 0.0891 mL 0.4457 mL 0.8914 mL 2.2286 mL
50 mM 0.0713 mL 0.3566 mL 0.7131 mL 1.7828 mL
60 mM 0.0594 mL 0.2971 mL 0.5943 mL 1.4857 mL
80 mM 0.0446 mL 0.2229 mL 0.4457 mL 1.1143 mL
100 mM 0.0357 mL 0.1783 mL 0.3566 mL 0.8914 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Linolelaidic acid506-21-8Linoelaidic acid亚麻酸Endogenous MetaboliteParasiteApoptosisHuman umbilicalvein endothelial cells (HUVECs)P. berghei (ANKA) strain-induced malaria C57BL/6 mice modelAnti-inflammatory activityAntioxidant stress-reducing activityAnti-parasitic activityInhibitorinhibitorinhibit

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