1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
  3. OSI-296

OSI-296是一种有效的口服选择性cMETRON激酶抑制剂。OSI-296在MKN45肿瘤异种移植模型中显示出体内有效性,并且耐受性良好。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

OSI-296 Chemical Structure

OSI-296 Chemical Structure

CAS No. : 1175296-94-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
0.2 μM
Compound: 6, OSI-296
Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs
Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs
[PMID: 23773865]
MKN-45 IC50
0.042 μM
Compound: 6, OSI-296
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs
[PMID: 23773865]
MKN-45 IC50
0.13 μM
Compound: 6, OSI-296
Antiproliferative activity against human MKN45 cells after 3 days by CellTiter-Glo assay
Antiproliferative activity against human MKN45 cells after 3 days by CellTiter-Glo assay
[PMID: 23773865]
MKN-45 IC50
0.6 μM
Compound: 6, OSI-296
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasma
Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasma
[PMID: 23773865]
MKN-45 ED50
50 mg/kg
Compound: 6, OSI-296
Antitumor activity against human MKN45 cells xenografted in po dosed nu/nu CD1 mouse model assessed as tumor growth inhibition administered qd for 14 days
Antitumor activity against human MKN45 cells xenografted in po dosed nu/nu CD1 mouse model assessed as tumor growth inhibition administered qd for 14 days
[PMID: 23773865]
分子量

465.30

Formula

C21H19Cl2FN4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
OSI-296
目录号:
HY-118269
需求量:
我们的 Cookie 政策

我们使用 Cookies 和类似技术以提高网站的性能和提升您的浏览体验,部分功能也使用 Cookies 帮助我们更好地理解您的需求,为您提供相关的服务。 如果您有任何关于我们如何处理您个人信息的疑问,请阅读我们的《隐私声明》