2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP7-IN-22

PARP7-IN-22 (XLY-1) 是一种 PARP7 抑制剂，IC50 为 0.6 nM。PARP7-IN-22 具有口服有效性，能够增强体外的 I 型干扰素信号传导，恢复 I 型干扰素信号并促进 T 细胞浸润肿瘤组织，对肿瘤生长具有显著抑制作用。PARP7-IN-22 有望用于癌症免疫领域研究。

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PARP7-IN-22 Chemical Structure

PARP7-IN-22 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

PARP7-IN-22 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARP7-IN-22 (XLY-1) is a PARP7 inhibitor with an IC50 of 0.6 nM. PARP7-IN-22 (XLY-1) is orally active, enhances type I interferon signaling in vitro, restores type I interferon signaling, promotes T cell infiltration into tumor tissues, and significantly inhibits tumor growth. PARP7-IN-22 shows promise for research in the field of cancer immunotherapy[1].
IC50 & Target[1]

PARP-7

0.6 nM (IC50)

体外研究
(In Vitro)

PARP7-IN-22 (XLY-1) (5μM - 20μM, 14天) 对 CT26 细胞的活性没有显著影响[1]。
PARP7-IN-22 (XLY-1) (49 nM - 4000 nM, 72小时) 以剂量依赖性方式显著增强了 IFN-β 和 CXCL10 的表达以及 STAT1 的磷酸化[1]。
PARP7-IN-22 (XLY-1) (49 nM - 4000 nM, 72 小时) 处理显著增加了蛋白激酶 TBK 1的磷酸化[1]。
PARP7-IN-22 (XLY-1) (49 nM - 4000 nM, 72 小时) 有效地促进了 I 型干扰素信号传导级联反应，从而发挥了抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PARP7-IN-22 相关抗体:

RT-PCR[1]

Cell Line: CT26 cells
Concentration: 49 nM-4000 nM
Incubation Time: 72 h
Result: Resulted in a gradual increase in the mRNA levels of IFN-β and CXCL10 as the dose ranged from 49 nM to 4000 nM.

Western Blot Analysis[1]

Cell Line: CT26 cells
Concentration: 49 nM-4000 nM
Incubation Time: 72 h
Result: Resulted in a dose-dependent increase in the protein levels of STAT1 and TBK1, with STAT1 protein levels showing a dose-dependent increase in the range of 49 nM to 4000 nM.
体内研究
(In Vivo)

PARP7-IN-22 (XLY-1) (雄性大鼠，5 mg/kg，静脉注射；30 mg/kg，口服；0.5-24 小时) 可用于进一步的体内药效学研究[1]。
PARP7-IN-22 (CT26 同种移植模型，25 或 50 mg/kg，口服，14 天) 在 CT26 同种移植模型中展示出优异的抗肿瘤增殖效果[1]。
PARP7-IN-22 (CT26 同种移植模型，50 mg/kg，口服，14 天) 促进T 细胞浸润肿瘤组织，并表现出靶向效应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

508.42

Formula

C19H22F6N8O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARP7-IN-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP7-IN-22PARPpoly ADP ribose polymeraseCT26 cellsCT26 Syngeneic mouse modelCancerInhibitorinhibitorinhibit

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