2. Anti-infection Antibody-drug Conjugate/ADC Related Metabolic Enzyme/Protease
  3. Bacterial ADC Cytotoxin Antibiotic Mitochondrial Metabolism
  4. Piericidin A

Piericidin A  (Synonyms: AR-054)

目录号: HY-114936 纯度: ≥99.0%
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Piericidin A (AR-054) 是一种天然线粒体 NADH-泛醌氧化还原酶 (复合物 I; complex I) 抑制剂。Piericidin A 是一种有效的神经毒素，通过其对 NADH-泛醌还原酶 (NADH-ubiquinone reductase) 的作用破坏电子传输系统，从而抑制线粒体呼吸。Piericidin A 还是一种潜在的群体感应抑制剂，可抑制胡萝卜欧文氏菌亚种 atroseptica (Eca) 的毒力基因的表达。Piericidin A 是一种 ADC 细胞毒素，具有抗菌，抗癌，杀虫活性。

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Piericidin A Chemical Structure

Piericidin A Chemical Structure

CAS No. : 2738-64-9

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1 mg (12.03 mM * 200 μL in Ethanol) ￥4500
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Piericidin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity[1][2][2].

体外研究
(In Vitro)

In a cell free assay, the potency of Piericidin A to inhibit mitochondrial complex I is ∼2 fold smaller than the one of annonacin. In cultured neurons, Piericidin A potently induces the redistribution of phosphorylated tau from the dendrites into the cell soma and induces cell death[1].
The viability of Tn5B1-4 cells is inhibited by Piericidin A in a time- and concentration-dependent manner with IC50 value of 0.061 μM, whilst Piericidin A shows slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC50 value of 233.97 μM and 228.96 μM, respectively. Piericidin A induces apoptosis of Tn5B1-4 cells coincides with a decrease in the mitochondrial membrane potential[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Piericidin A 相关抗体:
体内研究
(In Vivo)

Piericidin A (0.5 mg/kg/d; for 28 days via osmotic minipumps) significantly increases the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S+/+ mice. Piericidin A leads to increased levels of pathologically phosphorylated tau only in P301S+/+ mice. The synaptic density is reduced by Piericidin A treatment in P301S+/+ mice. Exposure to Piericidin A aggravates the course of genetically determined tau pathology[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

415.57

Formula

C25H37NO4
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

粉蝶霉素A
结构分类
初始来源

Streptomyces sp. BCC24731
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

COA (280 KB)

产品使用指南 (1538 KB)
参考文献

Piericidin A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Piericidin A2738-64-9AR-054粉蝶霉素AAR054AR 054BacterialADC CytotoxinAntibioticMitochondrial MetabolismADC PayloadInhibitorinhibitorinhibit

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