1. Others Metabolic Enzyme/Protease
  2. Isotope-Labeled Compounds Cytochrome P450
  3. Ticlopidine-d4

Ticlopidine-d4  (Synonyms: PCR 5332-d4)

目录号: HY-100386S
Data Sheet 产品使用指南 技术支持

Ticlopidine-d4 是 Ticlopidine 的氘代物。Ticlopidine (PCR 5332) 是一种抗血栓前体,作为非竞争性的变构 CD39 抑制剂,IC50 为 81.7 μM。Ticlopidine 阻断 NTPDase 同工酶,对 NTPDase2NTPDase3IC50 分别为 170 μM 和 149 μM。Ticlopidine 是 CYP2C19 人肝细胞色素的抑制剂。Ticlopidine 抑制 CYP2C9CYP3A4IC50 值分别为 26.0 和 32.3 μM。

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Ticlopidine-d<sub>4</sub> Chemical Structure

Ticlopidine-d4 Chemical Structure

CAS No. : 1246817-49-1

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规格 是否有货
2.5 mg Check price and availability
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Other Forms of Ticlopidine-d4:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ticlopidine-d4 is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively[2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

267.81

Formula

C14H10D4ClNS

CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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× = ×
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产品名称:
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目录号:
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