2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Tivozanib hydrochloride hydrate

Tivozanib hydrochloride hydrate  (Synonyms: AV-951 hydrochloride hydrate; KRN951 hydrochloride hydrate)

目录号: HY-10977A 纯度: 99.77%
COA 产品使用指南 技术支持

Tivozanib hydrochloride hydrate (AV-951 hydrate; KRN951 hydrate) 是 Tivozanib (HY-10977) 的水合盐酸盐形式。Tivozanib hydrochloride hydrate 是口服有效的血管内皮生长因子受体 (VEGFR)-1, 2 3 抑制剂，IC50 为 30，6.5 和 15 nM。Tivozanib hydrochloride hydrate 具有抗肿瘤活性。

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Tivozanib hydrochloride hydrate Chemical Structure

Tivozanib hydrochloride hydrate Chemical Structure

CAS No. : 682745-41-1

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥728
In-stock
5 mg ￥650
In-stock
10 mg ￥978
In-stock
25 mg ￥1600
In-stock
50 mg ￥2400
In-stock
100 mg ￥3575
In-stock
500 mg 现货 询价
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Tivozanib hydrochloride hydrate:

Tivozanib hydrochloride hydrate 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tivozanib hydrochloride hydrate is the hydrate hydrochloride form of Tivozanib (HY-10977). Tivozanib hydrochloride hydrate is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib hydrochloride hydrate exhibits antitumor efficacy[1].

IC50 & Target[3]

VEGFR-2

6.5 nM (IC50)

VEGFR-3

15 nM (IC50)

VEGFR-1

30 nM (IC50)

体外研究
(In Vitro)

Tivozanib hydrochloride hydrate 抑制 VEGFR-1、VEGFR-2 和 VEGFR-3 的磷酸化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tivozanib hydrochloride hydrate 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HUVECs
Concentration: 0-100 nM
Incubation Time: 24 h
Result: Inhibited Proliferation.

Cell Migration Assay [1]

Cell Line: HUVECs
Concentration: 0-100 nM
Incubation Time: 22 h
Result: Inhibited migration.

Western Blot Analysis[1]

Cell Line: HUVECs
Concentration: 0-300 nM
Incubation Time: 1 h
Result: Inhibited VEGR-dependent phosphorylation of ERK1 and ERK2.
体内研究
(In Vivo)

Tivozanib hydrochloride hydrate (1 mg/kg；口服；14 天) 抑制 CNV 病变的发展并导致已建立的 CNV 显著消退，使受影响的区域减少 67.7%[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Calu-6 tumor bearing athymic mice model[1]
Dosage: 0.04-1 mg/kg/day
Administration: p.o., for 14-21 days
Result: Inhibited tumor growth, angiogenesis and vascular permeability.
Clinical Trial
分子量

509.34

Formula

C22H22Cl2N4O6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (245.42 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9633 mL 9.8166 mL 19.6333 mL
5 mM 0.3927 mL 1.9633 mL 3.9267 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.77%

COA (296 KB) HNMR (277 KB) LCMS (263 KB)

产品使用指南 (1538 KB)
参考文献

Tivozanib hydrochloride hydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9633 mL 9.8166 mL 19.6333 mL 49.0831 mL
5 mM 0.3927 mL 1.9633 mL 3.9267 mL 9.8166 mL
10 mM 0.1963 mL 0.9817 mL 1.9633 mL 4.9083 mL
15 mM 0.1309 mL 0.6544 mL 1.3089 mL 3.2722 mL
20 mM 0.0982 mL 0.4908 mL 0.9817 mL 2.4542 mL
25 mM 0.0785 mL 0.3927 mL 0.7853 mL 1.9633 mL
30 mM 0.0654 mL 0.3272 mL 0.6544 mL 1.6361 mL
40 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2271 mL
50 mM 0.0393 mL 0.1963 mL 0.3927 mL 0.9817 mL
60 mM 0.0327 mL 0.1636 mL 0.3272 mL 0.8181 mL
80 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6135 mL
100 mM 0.0196 mL 0.0982 mL 0.1963 mL 0.4908 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tivozanib hydrochloride682745-41-1AV-951 hydrochlorideKRN951 hydrochlorideVEGFRVascular endothelial growth factor receptororally activeangiogenesisvascular permeabilityantitumorrenal cell carcinomaInhibitorinhibitorinhibit

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目录号：
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