2. Anti-infection
  3. Bacterial Fungal Influenza Virus Antibiotic
  4. Tyrothricin

Tyrothricin  (Synonyms: 酪丝菌素)

目录号: HY-120435 纯度: 96.4%
COA 产品使用指南

摩尔计算器

Tyrothricin 是一种从短小芽孢杆菌中分离的多肽抗生素混合物，由酪氨酸和短杆菌肽组成。Tyrothricin 可抑制细菌，真菌和某些病毒的活性。含 Tyrothricin 的制剂可用于治愈咽喉痛或浅表及小面积伤口的感染。

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Tyrothricin Chemical Structure

Tyrothricin Chemical Structure

CAS No. : 1404-88-2

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规格 价格 是否有货 数量
1 mg ￥560
In-stock
5 mg ￥1320
In-stock
10 mg ￥2240
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Tyrothricin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tyrothricin is a polypeptide antibiotic mixture isolated from Bacillus brevis and consists of tyrocidines and gramicidins. Tyrothricin shows activity against bacteria, fungi and some viruses. Tyrothricin containing formulations are used in sore throat agents and in agents for the healing of infected superficial and small-area wounds[1].

体外研究
(In Vitro)

Tyrothricin is a mixture of polypeptides, consisting of 50%-70% tyrocidines and 25%-50% gramicidins. The group of tyrocidines is basic, cyclic peptides, whereas the fraction of gramicidins is neutral, linear peptides. Besides physiological and essential L-amino acids, the components of Tyrothricin also contain D-amino acids[1].
Tyrothricin is produced by the gram-positive aerobic sporeforming bacterium Bacillus brevis (Strain ATCC 8185) during its sporulation phase via the nonribosomal pathway[1].
The efficacy spectrum of Tyrothricin mainly covers gram-positive but also several gram-negative bacteria. Corynebacteria and staphylococci show a broader range of Tyrothricin concentrations for inhibition (2-256 μg/mL). In contrast to the gramicidin fraction alone, Tyrothricin is able to inhibit all Staphylococcus strains at a maximum concentration of 128 μg/mL. Among the gram-negative organisms, gonococci and meningococci were the most sensitive germs (96 μg/mL)[1].
Tyrothricin exerts fungicidal effects on a variety of Candida species. Tyrothricin shows an anti-infectious activity against parainfluenza virus (type Sendai)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrothricin 相关抗体:
体内研究
(In Vivo)

In animal models using HSV type 1, a pre-incubation of the virus suspension with Tyrothricin could significantly decrease the lethality in mice. The effect could only be shown after a direct contact between Tyrothricin and the virus[1].
Nevertheless disruption of the integrity of eukaryotic membranes is observed at higher Tyrothricin concentrations in vitro. This effect is exemplified as hemolytic activity of Tyrothricin in in vitro studies and when applied to animals i.v.. In contrast to an intravenous (LD50 mouse: 3,7 mg/kg) and an intraperitoneal (LD50 mouse: 20-45 mg/kg) application the oral application is very well tolerated, as Tyrothricin is destroyed in the gastro-intestinal tract[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号
性状

固体

颜色

White to off-white

中文名称

酪丝菌素
结构分类
初始来源

Bacillus brevis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 96.4%

COA (279 KB)

产品使用指南 (1538 KB)
参考文献

Tyrothricin 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrothricin1404-88-2酪丝菌素BacterialFungalInfluenza VirusAntibioticantimicrobialtyrocidinesgramicidinsmixturepolypeptideantibacterialantifungalantiviralInhibitorinhibitorinhibit

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