2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. JAK Apoptosis
  4. ZT55

ZT55 是一种口服有效并具有高选择性的 JAK2 抑制剂，其 IC50 值为 0.031 μM。ZT55 能抑制表达 JAK2V617F 的 HEL 细胞系的增殖，并诱导细胞凋亡和周期停滞。ZT-55 还可有效抑制小鼠模型体内 HEL 异种移植肿瘤的生长。ZT-55 可用于骨髓增生性肿瘤、多血症以及原发性血小板增多症的研究。

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ZT55 Chemical Structure

ZT55 Chemical Structure

CAS No. : 2138488-38-5

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ZT55 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1].

IC50 & Target[1]

JAK2

0.031 μM (IC50)

体外研究
(In Vitro)

ZT55 (0-100 μM; 48 h) 以浓度依赖的方式对 JAK2V617F 表达阳性的 HEL 细胞显示抗增殖活性 (IC50=18.05 μM)[1]。
ZT55 (12.5, 25, 50 μM; 24, 48, 72 h) 以浓度和时间依赖的方式抑制 HEL 细胞的活力并诱导细胞凋亡[1]。
ZT55 (12.5, 25, 50 μM; 24 h) 以浓度依赖的方式诱导 HEL 细胞阻滞在 G2/M 期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZT55 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Significantly inhibited proliferation in a concentration-dependent manner (IC50=18.05 μM).

Cell Viability Assay[1]

Cell Line: HEL cells
Concentration: 12.5, 25, 50 μM
Incubation Time: 24, 48, 72 h
Result: Inhibited viability of HEL cells in a concentration- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 24, 48, 72 h
Result: Induced cell apoptosis in a concentration- and time-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HEL cells (JAK2V617F(+))
Concentration: 0-100 μM
Incubation Time: 24, 48, 72 h
Result: Significantly increased the number of HEL cells in the G2/M phase in a concentration-dependent manner.
体内研究
(In Vivo)

ZT55 (100 mg/kg; p.o; once a day for 2 weeks) 显著抑制裸鼠皮下 HEL 肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female, athymic BALB/c nude mice (6 to 8-week-old; JAK2V617F xenograft model)[1].
Dosage: 100 mg/kg
Administration: Oral administration; once a day for 2 weeks
Result: Induced marked reductions in tumor volume.
分子量

296.32

Formula

C17H16N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZT55 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZT552138488-38-5ZT 55ZT-55JAKApoptosisJanus kinaseMPNmyeloproliferative neoplasmspolycythemia vera and primary thrombocythemiaHEL cellsInhibitorinhibitorinhibit

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