α-Amyrin (Synonyms: α-香树脂醇)

目录号: HY-N8423 纯度: ≥99.0%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

α-Amyrin 是一种具有口服活性的五环三萜类化合物。α-Amyrin 可激活 ERK 和 GSK-3β 信号通路。α-Amyrin 可应用于高果糖饮食诱导的代谢综合征和低胆碱能神经传递所致的认知功能障碍的研究。

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α-Amyrin Chemical Structure

CAS No. : 638-95-9

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规格	价格	是否有货
1 mg	￥800	In-stock
5 mg	￥2000	In-stock
10 mg	￥3200	In-stock
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100 mg		询价

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Customer Review

Other Forms of α-Amyrin:

α-Amyrin (Standard) 询价

MCE 顾客使用本产品发表的 1 篇科研文献

•Trop Med Infect Dis. 2023 May 3, 8(5), 263.

α-Amyrin 相关产品

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ERK ERK1 ERK2 ERK5 ERK8

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GSK-3 GSK-3α GSK-3β

生物活性
纯度 & 产品资料
参考文献

生物活性

α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission^[1]^[2]^[3].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	GI₅₀	10.54 μM Compound: 58	Cytotoxicity against human A549 cells after 48 hrs by WST8 assay Cytotoxicity against human A549 cells after 48 hrs by WST8 assay	[PMID: 20371180]
B16	ED₅₀	> 50 μM Compound: 19	Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days	[PMID: 12027734]
B16	IC₅₀	50 μM Compound: 19	Growth inhibition of mouse B16 2F2 cells after 3 days Growth inhibition of mouse B16 2F2 cells after 3 days	[PMID: 12027734]
CHO	EC₅₀	> 10 μM Compound: Alpha-amyrin	Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay	[PMID: 19911773]
COS-1	EC₅₀	0 μM Compound: Alpha-amyrin	Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay	[PMID: 19911773]
HepG2	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
HepG2	IC₅₀	220 μM Compound: 8	Cytotoxicity against human Hep G2 cells after 48 hrs by WST-8 assay Cytotoxicity against human Hep G2 cells after 48 hrs by WST-8 assay	[PMID: 15730243]
J774	IC₅₀	128.5 μM Compound: 1	Cytotoxicity against mouse J774 cells by alamar blue assay Cytotoxicity against mouse J774 cells by alamar blue assay	[PMID: 17637068]
KB	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
Lu1	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
MCF7	IC₅₀	> 100 μM Compound: 8	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red assay	[PMID: 28318944]
PANC-1	GI₅₀	12.8 μM Compound: 58	Cytotoxicity against human PANC1 cells after 48 hrs by WST8 assay Cytotoxicity against human PANC1 cells after 48 hrs by WST8 assay	[PMID: 20371180]
PC-3	GI₅₀	7.66 μM Compound: 58	Cytotoxicity against human PC3 cells after 48 hrs by WST8 assay Cytotoxicity against human PC3 cells after 48 hrs by WST8 assay	[PMID: 20371180]
SH-SY5Y	EC₅₀	> 50 μM Compound: 37	Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 1-methyl-4-phenylpyridinium ion-induced cell death after 48 hrs by MTT assay Neuroprotective activity in human SH-SY5Y cells assessed as reduction in 1-methyl-4-phenylpyridinium ion-induced cell death after 48 hrs by MTT assay	[PMID: 27420919]
SH-SY5Y	EC₅₀	13.3 μM Compound: 37	Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay Neuroprotective activity in human SH-SY5Y cells assessed as reduction in oxygen glucose deprivation-induced cell death incubated for 16 hrs under hypoxic condition followed by incubation for 24 hrs under normoxic condition by MTT assay	[PMID: 27420919]
WI-38	IC₅₀	12.7 μM Compound: 8	Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay Cytotoxicity against human WI 38 cells after 48 hrs by WST-8 assay	[PMID: 15730243]
WI-38 VA13	IC₅₀	> 235 μM Compound: 8	Cytotoxicity against human VA13 cells after 48 hrs by WST-8 assay Cytotoxicity against human VA13 cells after 48 hrs by WST-8 assay	[PMID: 15730243]

体外研究
(In Vitro)

α-Amyrin (10 μM, 24 h) 可诱导 C2C12 成肌细胞 AMPK 和 PPARδ/γ 介导的 GLUT4 易位^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	C2C12
Concentration:	1, 10 100 μM
Incubation Time:	24 h
Result:	Reduced cell viability at 100 μM.

Western Blot Analysis^[1]

Cell Line:	C2C12
Concentration:	10 μM
Incubation Time:	24 h
Result:	Increased the mRNA and protein expression of PPARs, GLUT4 and FATP.

体内研究
(In Vivo)

α-Amyrin (50, 100, 200 mg/kg, 口服, 每日一次连续 42 天) 可减轻大鼠高果糖饮食诱导的代谢综合征存活率^[2]。
α-Amyrin (2 或 4 mg/kg, 口服) 通过激活 ERK 和 GSK-3β 信号通路，改善小鼠低胆碱能神经传递所致的认知功能障碍^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fructose diet (HFD)-induced metabolic syndrome in rats^[2]
Dosage:	50, 100, 200 mg/kg
Administration:	p.o.
Result:	Decreased systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides. Attenuated hepatic oxidative stress as well as micro- and macrovesicular fatty changes in hepatocytes caused by HFD.

Animal Model:	Scopolamine-Induced Memory Impairment Mice^[3]
Dosage:	2 or 4 mg/kg
Administration:	p.o.
Result:	Increased the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β).

分子量

426.72

Formula

C₃₀H₅₀O

CAS 号

638-95-9

性状

固体

颜色

White to off-white

中文名称

α-香树脂醇

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

Methanol 中的溶解度 : 1 mg/mL (2.34 mM; 超声助溶 (<60°C))

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3435 mL	11.7173 mL	23.4346 mL
5 mM	---	---	---
10 mM	---	---	---

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.94%

选择批次：

Data Sheet (612 KB) SDS (252 KB)

COA (197 KB) HNMR (294 KB) RP-HPLC (133 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Giacoman-Martínez A, et al. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Can J Physiol Pharmacol. 2021 Sep;99(9):935-942. [Content Brief]

[2]. Prabhakar P, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Appl Physiol Nutr Metab. 2017 Jan;42(1):23-32. [Content Brief]

[3]. Park SJ, et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol Pharm Bull. 2014;37(7):1207-13. [Content Brief]

α-Amyrin 相关分类

Neurological Disease Metabolic Disease

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

Methanol

1 mM

2.3435 mL

11.7173 mL

23.4346 mL

58.5864 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Amyrin638-95-9α-香树脂醇ERKGSK-3Extracellular signal regulated kinasesGlycogen synthase kinase-3Glycogen synthase kinase 3pentacyclic triterpenoidAmyrinantinociceptiveanti-inflammatoryInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

α-Amyrin (Synonyms: α-香树脂醇)

Customer Review

Other Forms of α-Amyrin:

MCE 顾客使用本产品发表的 1 篇科研文献