Bisantrene (Synonyms: 比生群; CL216942)

目录号: HY-100875 纯度: 98.08%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

Bisantrene 是高效的抗癌剂，它通过影响 DNA 插入发挥细胞毒性。Bisantrene 靶向真核生物的拓扑异构酶 II。Bisantrene 是 MDR1 的底物。

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Bisantrene Chemical Structure

CAS No. : 78186-34-2

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10 mg	￥550	In-stock
25 mg	￥1200	In-stock
50 mg	￥2000	In-stock
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Other Forms of Bisantrene:

Bisantrene dihydrochloride In-stock

MCE 顾客使用本产品发表的 5 篇科研文献

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Topoisomerase Topo I Topo II

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Bisantrene is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene targets eukaryotic type II topoisomerases. Bisantrene is a substrate of MDR1^[1]^[2]^[3]^[4].

IC₅₀ & Target^[1]

Topoisomerase II

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.017 μM Compound: 1	Compound was tested for potency against human lung A549 cells using sulforhodamine B assay. Compound was tested for potency against human lung A549 cells using sulforhodamine B assay.	[PMID: 9371238]
RPMI-8226	IC₅₀	0.018 μM Compound: 1	Compound was tested for potency against human myeloma 8226 cells using MTT assay method. Compound was tested for potency against human myeloma 8226 cells using MTT assay method.	[PMID: 9371238]

体外研究
(In Vitro)

Bisantrene 促进 DNase I 在寡嘌呤-寡嘧啶链上的切割，并略微降低在交替的嘌呤-嘧啶序列上的切割活性^[1]。
Bisantrene 是 [³H]尿苷掺入RNA和 [³H]胸苷掺入 DNA 的抑制剂^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Bisantrene 是一种抗肿瘤剂，对多种实验性肿瘤具有活性，包括 P388 白血病、L1210 白血病、Lieberman 浆细胞瘤、B16 黑色素瘤、结肠肿瘤 26 和 Ridgway 成骨肉瘤^[3]。
Bisantrene 在 1.56 至 150 mg/kg 的剂量范围内有效，具体取决于处理的频率、途径和时间表以及使用的肿瘤模型^[3]。
Bisantrene (25，50 和 100 mg/kg；腹腔注射；once) 预处理巨噬细胞对注射 P815 肿瘤细胞的小鼠显示出抗肿瘤作用^[3]。
Bisantrene (10-150 mg/kg；静脉注射；一次) 在 Neo 小鼠中剂量依赖性地诱导白细胞减少。B 细胞和巨噬细胞是 Bisantrene 毒性的靶标^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

398.46

Formula

C₂₂H₂₂N₈

CAS 号

78186-34-2

性状

固体

颜色

Orange to red

中文名称

比生群；必桑郡

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : 1 mg/mL (2.51 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5097 mL	12.5483 mL	25.0966 mL
5 mM	---	---	---
10 mM	---	---	---

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.08%

选择批次：

Data Sheet (629 KB) SDS (537 KB)

COA (290 KB) HNMR (277 KB) LCMS (261 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45. [Content Brief]

[2]. Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43(3):1402-4. [Content Brief]

[3]. Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazole-2-yl)hydrazone] dihydrochloride (bisantrene). Cancer Res. 1984 Jun;44(6):2363-7. [Content Brief]

[4]. Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2(6):973-80. [Content Brief]

Kinase Assay ^[1]	Measurements are carried out at 25°C in ETN buffer (1 mM EDTA, 10 mM Tris, pH 7.0, with NaCl to obtain the desired ionic strength). Binding is monitored spectrophotometrically or fluorometrically, in the ligand absorption or emission region, respectively, after addition of scalar amounts of DNA to a freshly prepared drug solution. To avoid large systematic inaccuracies resulting from experimental errors in extinction coefficients or fluorescence quantum yield, the range of bound drug fractions is 0.15-0.85. Data are evaluated. Spectroscopic measurements are made with a Perkin-Elmer Lambda 5 apparatus and a MPF66 fluorometer, both equipped with a Haake F3-C thermostat^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45. [Content Brief] [2]. Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43(3):1402-4. [Content Brief] [3]. Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazole-2-yl)hydrazone] dihydrochloride (bisantrene). Cancer Res. 1984 Jun;44(6):2363-7. [Content Brief] [4]. Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2(6):973-80. [Content Brief]

Kinase Assay
^[1]

Measurements are carried out at 25°C in ETN buffer (1 mM EDTA, 10 mM Tris, pH 7.0, with NaCl to obtain the desired ionic strength). Binding is monitored spectrophotometrically or fluorometrically, in the ligand absorption or emission region, respectively, after addition of scalar amounts of DNA to a freshly prepared drug solution. To avoid large systematic inaccuracies resulting from experimental errors in extinction coefficients or fluorescence quantum yield, the range of bound drug fractions is 0.15-0.85. Data are evaluated. Spectroscopic measurements are made with a Perkin-Elmer Lambda 5 apparatus and a MPF66 fluorometer, both equipped with a Haake F3-C thermostat^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54(6):1036-45. [Content Brief]

[2]. Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43(3):1402-4. [Content Brief]

[3]. Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[(4,5-dihydro-1H-imidazole-2-yl)hydrazone] dihydrochloride (bisantrene). Cancer Res. 1984 Jun;44(6):2363-7. [Content Brief]

[4]. Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2(6):973-80. [Content Brief]

Bisantrene 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO

1 mM

2.5097 mL

12.5483 mL

25.0966 mL

62.7416 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Bisantrene (Synonyms: 比生群; CL216942)

Customer Review

Other Forms of Bisantrene:

MCE 顾客使用本产品发表的 5 篇科研文献