2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. L-SelenoMethionine

L-SelenoMethionine  (Synonyms: L-硒代蛋氨酸)

目录号: HY-B1000A 纯度: 99.82%
COA 产品使用指南

摩尔计算器

L-SelenoMethionine 是 Selenomethionine 的 L-异构体，是硒的主要天然食物形式。L-SelenoMethionine 是一种癌症化学预防剂，可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。L-SelenoMethionine 还可以增加谷胱甘肽过氧化物酶的表达。

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L-SelenoMethionine Chemical Structure

L-SelenoMethionine Chemical Structure

CAS No. : 3211-76-5

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥440
In-stock
100 mg ￥400
In-stock
500 mg ￥1200
In-stock
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

Other Forms of L-SelenoMethionine:

L-SelenoMethionine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase[1][2][3].

IC50 & Target

Microbial Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
65 μM
Compound: 3
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
DU-145 IC50
40 μM
Compound: 3
Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
HT-29 IC50
130 μM
Compound: 3
Anticancer activity against human HT-29 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human HT-29 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
UACC-375 IC50
50 μM
Compound: 3
Anticancer activity against human UACC-375 cells assessed as cell growth inhibition measured after 6 days by SRB assay
Anticancer activity against human UACC-375 cells assessed as cell growth inhibition measured after 6 days by SRB assay
[PMID: 34217061]
体外研究
(In Vitro)

L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells[2].
? L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells[2].
? L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells[2].
? L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-SelenoMethionine 相关抗体:

Cell Viability Assay[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 1, 5, 10, 50, 100, 500 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited the growth of prostate cancer cells, with a lower IC50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).

Apoptosis Analysis[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells.
Exhibited the nicked-end DNA labeling in prostate cancer cells.
Promoted the PARP cleavage in prostate cancer cells.

Cell Cycle Analysis[2]

Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration: 500 μM
Incubation Time: 48 hours
Result: Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%).
Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.

RT-PCR[3]

Cell Line: Human thyroid epithelial cells (HTori-3)
Concentration: 5 μM
Incubation Time: 24 hours
Result: Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
体内研究
(In Vivo)

L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

196.11

Formula

C5H11NO2Se
CAS 号
性状

固体

颜色

White to off-white

中文名称

L-硒代蛋氨酸
结构分类
初始来源

Widespread
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

H2O 中的溶解度 : 14.29 mg/mL (72.87 mM; 超声助溶)

DMSO 中的溶解度 : 1 mg/mL (5.10 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.0992 mL 25.4959 mL 50.9918 mL
5 mM 1.0198 mL 5.0992 mL 10.1984 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 9.09 mg/mL (46.35 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.82%

COA (189 KB) HNMR (241 KB) RP-HPLC (244 KB)

产品使用指南 (1538 KB)
参考文献

L-SelenoMethionine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.0992 mL 25.4959 mL 50.9918 mL 127.4795 mL
5 mM 1.0198 mL 5.0992 mL 10.1984 mL 25.4959 mL
H2O 10 mM 0.5099 mL 2.5496 mL 5.0992 mL 12.7479 mL
15 mM 0.3399 mL 1.6997 mL 3.3995 mL 8.4986 mL
20 mM 0.2550 mL 1.2748 mL 2.5496 mL 6.3740 mL
25 mM 0.2040 mL 1.0198 mL 2.0397 mL 5.0992 mL
30 mM 0.1700 mL 0.8499 mL 1.6997 mL 4.2493 mL
40 mM 0.1275 mL 0.6374 mL 1.2748 mL 3.1870 mL
50 mM 0.1020 mL 0.5099 mL 1.0198 mL 2.5496 mL
60 mM 0.0850 mL 0.4249 mL 0.8499 mL 2.1247 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-SelenoMethionine3211-76-5L-硒代蛋氨酸Endogenous MetaboliteApoptosisseleniumcancerchemopreventivedietaryapoptosisglutathioneperoxidaseInhibitorinhibitorinhibit

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