2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Endogenous Metabolite
  4. γ-Aminobutyric acid

γ-Aminobutyric acid  (Synonyms: γ-氨基丁酸; 4-Aminobutyric acid)

目录号: HY-N0067 纯度: 99.71%
COA 产品使用指南

摩尔计算器

γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质，能够与离子移变 GABAA 受体和促代谢 GABAB 受体结合发挥作用。γ-Aminobutyric acid 能够阻断中枢神经系统的特定信号，并带来镇静效果。

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γ-Aminobutyric acid Chemical Structure

γ-Aminobutyric acid Chemical Structure

CAS No. : 56-12-2

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥550
In-stock
100 mg ￥500
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of γ-Aminobutyric acid:

γ-Aminobutyric acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system[1][2].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM[3].
Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation[4].
γ-Aminobutyric acid activates GABA A receptors, causing cell cycle arrest in S phase and limiting growth[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Aminobutyric acid 相关抗体:

Cell Migration Assay [4]

Cell Line: Cortical plate (cp) neurons
Concentration: 1-5 μM
Incubation Time: 18 hours
Result: Promoted motility via G-protein activation and arrested attractantinduced migration via GABAA receptor-mediated depolarization.
体内研究
(In Vivo)

γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice[6].
γ-Aminobutyric acid (1, 2, 4 mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure[7].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogens free (SPF) Bagg’s albino (Balb/c) mice (18–20 g, 8 weeks old)[6]
Dosage: 33.95, 102.25, 306.75 mg/kg
Administration: Oral gavage; single dose; 20 mL/kg administration; measured in an hour
Result: Prolonged the sleep duration, increased sleep rate, and shorten the sleep latency more effectively.
Animal Model: Sprague-Dawley rat indued by DEHP (HY-B1945) (500 mg/kg)[7]
Dosage: 1, 2, 4 mg/kg
Administration: Oral gavage; combined administration; for 30 consecutive days
Result: Reduced the levels of nitric oxide and nitric oxide synthase in rats treated with DEHP.
分子量

103.12

Formula

C4H9NO2
CAS 号
性状

固体

颜色

White to off-white

中文名称

γ-氨基丁酸
结构分类
初始来源

mammalian central nervous system
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

RT, protect from light
溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (484.87 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 9.6974 mL 48.4872 mL 96.9744 mL
5 mM 1.9395 mL 9.6974 mL 19.3949 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (969.74 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.71%

COA (280 KB) HNMR (113 KB) RP-HPLC (141 KB)

产品使用指南 (1538 KB)
参考文献

γ-Aminobutyric acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.6974 mL 48.4872 mL 96.9744 mL 242.4360 mL
5 mM 1.9395 mL 9.6974 mL 19.3949 mL 48.4872 mL
10 mM 0.9697 mL 4.8487 mL 9.6974 mL 24.2436 mL
15 mM 0.6465 mL 3.2325 mL 6.4650 mL 16.1624 mL
20 mM 0.4849 mL 2.4244 mL 4.8487 mL 12.1218 mL
25 mM 0.3879 mL 1.9395 mL 3.8790 mL 9.6974 mL
30 mM 0.3232 mL 1.6162 mL 3.2325 mL 8.0812 mL
40 mM 0.2424 mL 1.2122 mL 2.4244 mL 6.0609 mL
50 mM 0.1939 mL 0.9697 mL 1.9395 mL 4.8487 mL
60 mM 0.1616 mL 0.8081 mL 1.6162 mL 4.0406 mL
80 mM 0.1212 mL 0.6061 mL 1.2122 mL 3.0304 mL
100 mM 0.0970 mL 0.4849 mL 0.9697 mL 2.4244 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Aminobutyric acid56-12-24-Aminobutyric acidγ-氨基丁酸GABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAGADpolyamineneurotransmittercentral nervous systemCNSionotropicmetabotropicdevelopmentchemotaxiscortexG-proteindepolarizationneuronmigrationInhibitorinhibitorinhibit

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