γ-Aminobutyric acid (Synonyms: γ-氨基丁酸; 4-Aminobutyric acid)

目录号: HY-N0067 纯度: 99.71%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质，能够与离子移变 GABA_A 受体和促代谢 GABA_B 受体结合发挥作用。γ-Aminobutyric acid 能够阻断中枢神经系统的特定信号，并带来镇静效果。

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γ-Aminobutyric acid Chemical Structure

CAS No. : 56-12-2

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规格	价格	是否有货
10 mM * 1 mL in Water	￥550	In-stock
100 mg	￥500	In-stock
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MCE 顾客使用本产品发表的 3 篇科研文献

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生物活性
纯度 & 产品资料
参考文献

生物活性

γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABA_A receptors) and metabotropic receptors (GABA_B receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system^[1]^[2].

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.43 μM Compound: GABA	Antagonist activity at human rho1 GABAc receptor in HEK293 cells by FMP assay Antagonist activity at human rho1 GABAc receptor in HEK293 cells by FMP assay	[PMID: 17722904]
HEK293	EC₅₀	0.53 μM Compound: GABA	Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hrs by luciferase reporter gene assay Agonist activity at human GABA-B B1/B2 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 3 hrs by luciferase reporter gene assay	[PMID: 23428109]
HEK293	EC₅₀	0.55 μM Compound: GABA	Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by FMP assay	[PMID: 17655213]
HEK293	EC₅₀	12.8 μM Compound: GABA	Agonist activity at rat GABA alpha-1-T129S-beta-2-gamma-2 receptor mutant expressed in HEK293 cells by Whole-cell patch-clamp technique Agonist activity at rat GABA alpha-1-T129S-beta-2-gamma-2 receptor mutant expressed in HEK293 cells by Whole-cell patch-clamp technique	[PMID: 17655213]
HEK293	EC₅₀	354 μM Compound: 119	Substrate uptake by the Taurine Transporter (TauT, SLC6A6) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A6 cells Substrate uptake by the Taurine Transporter (TauT, SLC6A6) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A6 cells	10.5281/zenodo.7360560
HEK293	EC₅₀	36 μM Compound: 119	Substrate uptake by the Sodium- and Chloride-Dependent BetaineTransporter (BGT-1, SLC6A12) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A12 cells Substrate uptake by the Sodium- and Chloride-Dependent BetaineTransporter (BGT-1, SLC6A12) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A12 cells	10.5281/zenodo.7360527
HEK293	EC₅₀	43 μM Compound: GABA	Agonist activity at GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique Agonist activity at GABA alpha-1-beta-2-gamma-2 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique	[PMID: 17655213]
HEK293	IC₅₀	5 μM Compound: 1, GABA	Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis	[PMID: 23336362]
HEK293	EC₅₀	6 μM Compound: GABA	Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique Agonist activity at human GABAC rho 1 receptor expressed in HEK293 cells by Whole-cell patch-clamp technique	[PMID: 17655213]
IMR-32	EC₅₀	2.94 μM Compound: GABA	Agonist activity at GABA type-A receptor in human IMR32 cells after 2 hrs by Epic DMR assay Agonist activity at GABA type-A receptor in human IMR32 cells after 2 hrs by Epic DMR assay	10.1039/C5MD00442J
Oocyte	EC₅₀	0.8 μM Compound: 1, GABA	Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	[PMID: 18528996]
Oocyte	EC₅₀	0.99 μM Compound: GABA	Agonist activity at human alpha1beta2gamma2L GABAA receptor expressed in Xenopus oocytes assessed as potentiation of channel current response by two-electrode voltage clamp electrophysiology assay Agonist activity at human alpha1beta2gamma2L GABAA receptor expressed in Xenopus oocytes assessed as potentiation of channel current response by two-electrode voltage clamp electrophysiology assay	[PMID: 22029276]
Oocyte	EC₅₀	1.19 μM Compound: GABA	Agonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method Agonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp method	[PMID: 17981464]
Oocyte	EC₅₀	1.7 μM Compound: 1, GABA	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	[PMID: 18528996]
Oocyte	EC₅₀	10 μM Compound: GABA	Activity at rat wild type GABAA alpha-1-beta-2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method Activity at rat wild type GABAA alpha-1-beta-2 receptor expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method	[PMID: 18651727]
Oocyte	EC₅₀	136 μM Compound: GABA	Activity at rat GABAA alpha-1T129C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method Activity at rat GABAA alpha-1T129C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method	[PMID: 18651727]
Oocyte	EC₅₀	21.1 μM Compound: 1, GABA	Agonist activity at human alpha-1-beta-2-gamma-2L GABAA receptor expressed in Xenopus oocytes assessed as inhibition of current production by two electrode voltage clamp method Agonist activity at human alpha-1-beta-2-gamma-2L GABAA receptor expressed in Xenopus oocytes assessed as inhibition of current production by two electrode voltage clamp method	[PMID: 18528996]
Oocyte	EC₅₀	430 μM Compound: GABA	Activity at rat GABAA alpha-1F64C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method Activity at rat GABAA alpha-1F64C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method	[PMID: 18651727]
Oocyte	EC₅₀	5540 μM Compound: GABA	Activity at rat GABAA alpha-1R66C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method Activity at rat GABAA alpha-1R66C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method	[PMID: 18651727]
Oocyte	EC₅₀	6.5 μM Compound: GABA	Activity at rat GABAA alpha-1S68C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method Activity at rat GABAA alpha-1S68C-beta-2 receptor mutant expressed in Xenopus laevis oocytes at -60 mV by Two-Electrode voltage clamp method	[PMID: 18651727]

体外研究
(In Vitro)

γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM^[3].
Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation^[4].
γ-Aminobutyric acid activates GABA _A receptors, causing cell cycle arrest in S phase and limiting growth^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[4]

Cell Line:	Cortical plate (cp) neurons
Concentration:	1-5 μM
Incubation Time:	18 hours
Result:	Promoted motility via G-protein activation and arrested attractantinduced migration via GABAA receptor-mediated depolarization.

体内研究
(In Vivo)

γ-Aminobutyric acid (33.95, 102.25, 306.75 mg/kg; p.o.; single dose) can enhance the sleep of mice^[6].
γ-Aminobutyric acid (1, 2, 4 mg/kg/d; p.o.; 30 d) alleviates anxiety and restored food utilization rate in rats, with impairment induced by Di(2-ethylhexyl) phthalate (DEHP) exposure^[7].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Pathogens free (SPF) Bagg’s albino (Balb/c) mice (18–20 g, 8 weeks old)^[6]
Dosage:	33.95, 102.25, 306.75 mg/kg
Administration:	Oral gavage; single dose; 20 mL/kg administration; measured in an hour
Result:	Prolonged the sleep duration, increased sleep rate, and shorten the sleep latency more effectively.

Animal Model:	Sprague-Dawley rat indued by DEHP (HY-B1945) (500 mg/kg)^[7]
Dosage:	1, 2, 4 mg/kg
Administration:	Oral gavage; combined administration; for 30 consecutive days
Result:	Reduced the levels of nitric oxide and nitric oxide synthase in rats treated with DEHP.

分子量

103.12

Formula

C₄H₉NO₂

CAS 号

56-12-2

性状

固体

颜色

White to off-white

中文名称

γ-氨基丁酸

结构分类

Ketones, Aldehydes, Acids

初始来源

动物

内源性代谢物

mammalian central nervous system

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

RT, protect from light

In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

H₂O 中的溶解度 : 50 mg/mL (484.87 mM; 超声助溶)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	9.6974 mL	48.4872 mL	96.9744 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (969.74 mM); 澄清溶液; 超声助溶 (<60°C)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 99.71%

选择批次：

Data Sheet (618 KB) SDS (393 KB)

COA (280 KB) HNMR (113 KB) RP-HPLC (141 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2. [Content Brief]

[2]. Okada R, et al. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514(1):74-91. [Content Brief]

γ-Aminobutyric acid 相关分类

Neurological Disease

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	9.6974 mL	48.4872 mL	96.9744 mL	242.4360 mL
	5 mM	1.9395 mL	9.6974 mL	19.3949 mL	48.4872 mL
	10 mM	0.9697 mL	4.8487 mL	9.6974 mL	24.2436 mL
	15 mM	0.6465 mL	3.2325 mL	6.4650 mL	16.1624 mL
	20 mM	0.4849 mL	2.4244 mL	4.8487 mL	12.1218 mL
	25 mM	0.3879 mL	1.9395 mL	3.8790 mL	9.6974 mL
	30 mM	0.3232 mL	1.6162 mL	3.2325 mL	8.0812 mL
	40 mM	0.2424 mL	1.2122 mL	2.4244 mL	6.0609 mL
	50 mM	0.1939 mL	0.9697 mL	1.9395 mL	4.8487 mL
	60 mM	0.1616 mL	0.8081 mL	1.6162 mL	4.0406 mL
	80 mM	0.1212 mL	0.6061 mL	1.2122 mL	3.0304 mL
	100 mM	0.0970 mL	0.4849 mL	0.9697 mL	2.4244 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

γ-Aminobutyric acid (Synonyms: γ-氨基丁酸; 4-Aminobutyric acid)

Customer Review

Other Forms of γ-Aminobutyric acid:

MCE 顾客使用本产品发表的 3 篇科研文献