2. Apoptosis
  3. Apoptosis
  4. Antitumor agent-36

Antitumor agent-36 具有有效的抗增殖和抗转移活性。Antitumor agent-36 诱导严重的 DNA 损伤并进一步导致 γ-H2AX 和 p53 的高表达。Antitumor agent-36 通过线粒体凋亡通路 Bcl-2/Bax/caspase3 促进肿瘤细胞凋亡 (apoptosis)。Antitumor agent-36 通过抑制 PD-L1 的表达以增加肿瘤组织中 CD3+ 和 CD8+ T 浸润细胞显著改善免疫反应。

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Antitumor agent-36 Chemical Structure

Antitumor agent-36 Chemical Structure

CAS No. : 3005986-81-9

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Antitumor agent-36 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-36 possesses potent anti-proliferative and anti-metastasis activities. Antitumor agent-36 induces serious DNA damage and further leads to high expression of γ-H2AX and p53. Antitumor agent-36 promotes apoptosis of tumor cells through mitochondrial apoptotic pathway Bcl-2/Bax/caspase3. Antitumor agent-36 significantly improves immune response through restraining the expression of PD-L1 to increase CD3+ and CD8+ T infiltrating cells in tumor tissues[1].

IC50 & Target

apoptosis[1]
体外研究
(In Vitro)

Antitumor agent-36 (compound 1) (24-76 hours) displays relatively lower activities after 24 h treatment, and the IC50 values decreases at 48 h, and the activities at 72 h are similar to that of 48 h[1].
Antitumor agent-36 (compound 1) (24 hours) induces significant apoptosis of tumor cells.[1].
Antitumor agent-36 (compound 1) (24 hours) are effective in modulating the expression of apoptotic proteins in tumor cells [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-36 相关抗体:

Apoptosis Analysis[1]

Cell Line: murine tumor cell line 4T1 and human tumor cell line A549
Concentration: 5 and 10 μM
Incubation Time: 24 hours
Result: Exhibited effective apoptosis induction of both A549 and 4T1 cells after 24 h treatment.
分子量

806.60

Formula

C32H32Cl2N2O6Pt
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-36 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-363005986-81-9Antitumor agent36Antitumor agent 36Apoptosisproliferativemetastasismitochondrial apoptotic pathwayimmune responseT infiltrating cellγ-H2AXp53Bcl-2Baxcaspase3PD-L1CD3+CD8+Inhibitorinhibitorinhibit

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