2. Apoptosis
  3. Apoptosis
  4. ARF(26–44), cell-permeable

ARF(26–44), cell-permeable 是一种抗肿瘤肽，来源于 p14ARF 肿瘤抑制蛋白的特定氨基酸序列。ARF(26–44) cell-permeable 作为 FoxM1 (一种叉头框 M1 转录因子) 的功能抑制剂，在小鼠肝细胞癌 (HCC) 治疗中显示出了显著的抗肿瘤活性，能够显著增加肿瘤细胞的凋亡 (apoptosis) 以及减少肿瘤细胞增殖和血管生成。ARF(26–44), cell-permeable 可用于肿瘤治疗的研究。

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Custom Peptide Synthesis

ARF(26–44), cell-permeable Chemical Structure

ARF(26–44), cell-permeable Chemical Structure

CAS No. : 935732-44-8

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ARF(26–44), cell-permeable 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ARF(26–44), cell-permeable is a cell-penetrating peptide derived from a specific amino acid sequence of the p14ARF tumor suppressor protein. As a functional inhibitor of FoxM1, ARF(26–44) cell-permeable shows significant anti-tumor activity in the treatment of mouse hepatocellular carcinoma (HCC), significantly increasing tumor cell apoptosis and reducing tumor cell proliferation and angiogenesis. ARF(26–44), cell-permeable can be used in research on tumor therapy[1].

分子量

3585.22

Formula

C149H267N69O33S
CAS 号
Sequence

{d-(Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg)}-Lys-Phe-Val-Arg-Ser-Arg-Arg-Pro-Arg-Thr-Ala-Ser-Cys-Ala-Leu-Ala-Phe-Val-Asn
Sequence Shortening

{d-(Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg)}-KFVRSRRPRTASCALAFVN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ARF(26–44), cell-permeable 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARF(26–44), cell-permeable935732-44-8ApoptosisAntitumor activityapoptosiscell proliferationangiogenesispolypeptideInhibitorinhibitorinhibit

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